2.3.2.5: glutaminyl-peptide cyclotransferase

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For detailed information about glutaminyl-peptide cyclotransferase, go to the full flat file.

Reaction

Synonyms

AtQC, cyclotransferase, glutaminyl-transfer ribonucleate, DromeQC, gamma-glutamylamine cyclotransferase, GGACT, glutamine cyclotransferase, glutaminyl cyclase, glutaminyl-peptide cyclotransferase-like protein, glutaminyl-tRNA cyclotransferase, golgi resident enzyme, Golgi resident glutaminyl cyclase, Golgi-resident enzyme, Golgi-resident glutaminyl cyclase, gQC, h-isoQC, h-QC, hQC, isoDromeQC, isoGlutaminyl cyclase, isoQC, PgQC, QC, QCT, Qpct, Qpct1, QPCTL, secretory glutaminyl cyclase, sQC, StQC

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.2 Aminoacyltransferases

                2.3.2.5 glutaminyl-peptide cyclotransferase

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Results	in table
3	Activating Compound
2659	AA Sequence
13	Application
1	CAS Registry Number
40	Cloned(Commentary)
19	Crystallization (Commentary)
171	Disease/ Diagnostics
2	Expression
34	General Information
4	General Stability
49	IC50 Value
377	Inhibitors
142	kcat/KM [mM/s]
211	Ki Value [mM]
343	KM Value [mM]
36	Localization
29	Metals/Ions
22	Molecular Weight [Da]
52	Natural Substrates/ Products (Substrates)
107	Organism
1	Pathway
103	PDB ID
21	pH Optimum
3	pH Range
12	pH Stability
19	Posttranslational Modification
76	Protein Variants
29	Purification (Commentary)
3	Reaction
2	Reaction Type
98	Reference
140	Source Tissue
3	Specific Activity [micromol/min/mg]
1	Storage Stability
464	Substrates and Products (Substrate)
15	Subunits
129	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
4	Temperature Stability [°C]
326	Turnover Number [1/s]

pH Range

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pH Range on EC 2.3.2.5 - glutaminyl-peptide cyclotransferase

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pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

6.5 - 8.3

Bos taurus

-

pH 6.5: about 50% of maximal activity, pH 8.3: about 40% of maximal activity, pituitary enzyme

487992

7.5 - 9.3

Bos taurus

-

pH 7.5: about 55% of maximal activity, pH 9.3: about 45% of maximal activity, enzyme from spleen

487992

additional information

Carica papaya

-

activity changes very slightly in the pH range between 4.5 and 10

487993