2.3.2.5: glutaminyl-peptide cyclotransferase
This is an abbreviated version!
For detailed information about glutaminyl-peptide cyclotransferase, go to the full flat file.
Word Map on EC 2.3.2.5
-
2.3.2.5
-
pyroglutamate
-
alzheimer
-
cyclases
-
pyroglutamyl
-
papaya
-
pyroglutamate-modified
-
pglu-a
-
medicine
-
drug development
-
antivenomics
-
pharmacology
-
n-truncated
-
cd47-sirp
- 2.3.2.5
- pyroglutamate
- alzheimer
- cyclases
-
pyroglutamyl
- papaya
-
pyroglutamate-modified
-
pglu-a
- medicine
- drug development
-
antivenomics
- pharmacology
-
n-truncated
-
cd47-sirp
Reaction
Synonyms
AtQC, cyclotransferase, glutaminyl-transfer ribonucleate, DromeQC, gamma-glutamylamine cyclotransferase, GGACT, glutamine cyclotransferase, glutaminyl cyclase, glutaminyl-peptide cyclotransferase-like protein, glutaminyl-tRNA cyclotransferase, golgi resident enzyme, Golgi resident glutaminyl cyclase, Golgi-resident enzyme, Golgi-resident glutaminyl cyclase, gQC, h-isoQC, h-QC, hQC, isoDromeQC, isoGlutaminyl cyclase, isoQC, PgQC, QC, QCT, Qpct, Qpct1, QPCTL, secretory glutaminyl cyclase, sQC, StQC
ECTree
2.3.2.5 glutaminyl-peptide cyclotransferaseAdvanced search results
results (
results (Reference
top
Reference on EC 2.3.2.5 - glutaminyl-peptide cyclotransferase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Busby, W.H.; Quackenbush, G.E.; Humm, J.; Youngblood, W.W.; Kizer, J.S.
An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes
J. Biol. Chem.
262
8532-8536
1987
Bos taurus, Homo sapiens, Rattus norvegicus, Sus scrofa
Fischer, W.H.; Spiess, J.
Identification of a mammalian glutaminyl cyclase converting glutaminyl into pyroglutamyl peptides
Proc. Natl. Acad. Sci. USA
84
3628-3632
1987
Bos taurus, Rattus norvegicus
Oberg, K.A.; Ruysschaert, J.M.; Azarkan, M.; Smolders, N.; Zerhouni, S.; Wintjens, R.; Amrani, A.; Looze, Y.
Papaya glutamine cyclase, a plant enzyme highly resistant to proteolysis, adopts an all-b conformation
Eur. J. Biochem.
258
214-222
1998
Carica papaya
Sykes, P.A.; Watson, S.J.; Temple, J.S.; Bateman, R.C., Jr.
Evidence for tissue-specific forms of glutaminyl cyclase
FEBS Lett.
455
159-161
1999
Bos taurus
Gololobov, M.Y.; Song, I.; Wang, W.; Bateman, R.C.M.
Steady-state kinetics of glutamine cyclotransferase
Arch. Biochem. Biophys.
309
300-307
1994
Carica papaya
Dahl, S.W.; Slaughter, C.; Lauritzen, C.; Bateman, R.C., Jr.; Connerton, I.; Pedersen, J.
Carica papaya glutamine cyclotransferase belongs to a novel plant enzyme subfamily: cloning and characterization of the recombinant Enzyme
Protein Expr. Purif.
20
27-36
2000
Carica papaya (O81226), Carica papaya
Gololobov, M.Y.; Wang, W.; Bateman, R.C., Jr.
Substrate and inhibitor specificity of glutamine cyclotransferase (QC)
Biol. Chem. Hoppe-Seyler
377
395-398
1996
Carica papaya
Song, I.; Chuang, C.Z.; Bateman, J.R.C.
Molecular cloning, sequence analysis and expression of human pituitary glutaminyl cyclase
J. Mol. Endocrinol.
13
77-86
1994
Homo sapiens
Bateman, R.C., Jr.; Temple, J.S.; Misquitta, S.A.; Booth, R.E.
Evidence for essential histidines in human pituitary glutaminyl cyclase
Biochemistry
40
11246-11250
2001
Homo sapiens
Schilling, S.; Hoffmann, T.; Rosche, F.; Manhart, S.; Wasternack, C.; Demuth, H.U.
Heterologous expression and characterization of human glutaminyl cyclase: evidence for a disulfide bond with importance for catalytic activity
Biochemistry
41
10849-10857
2002
Homo sapiens
Zerhouni, S.; Amrani, A.; Nijs, M.; Vandermeers, A.; Looze, Y.
Purification and characterization of the plant glutaminyl-peptide cyclotransferase isolated from papaya latex
Int. J. Bio-Chromatogr.
3
189-206
1997
Carica papaya
-
Azarkan, M.; Amrani, A.; Zerhouni, S.; Oberg, K.A.; Ruysschaert, J.M.; Wintjens, R.; Looze, Y.
Evidence that thermodynamic stability of papaya glutamine cyclase is only marginal
Biopolymers
65
325-335
2002
Carica papaya
Azarkan, M.; Clantin, B.; Bompard, C.; Belrhali, H.; Baeyens-Volant, D.; Looze, Y.; Villeret, V.; Wintjens, R.
Crystallization and preliminary X-ray diffraction studies of the glutaminyl cyclase from Carica papaya latex
Acta Crystallogr. Sect. F
F61
59-61
2005
Carica papaya
Schilling, S.; Manhart, S.; Hoffmann, T.; Ludwig, H.H.; Wasternack, C.; Demuth, H.U.
Substrate specificity of glutaminyl cyclases from plants and animals
Biol. Chem.
384
1583-1592
2003
Carica papaya, Homo sapiens
Booth, R.E.; Lovell, S.C.; Misquitta, S.A.; Bateman, R.C., Jr.
Human glutaminyl cyclase and bacterial zinc aminopeptidase share a common fold and active site
BMC Biol.
2
2
2004
Homo sapiens (Q16769), Homo sapiens
Schilling, S.; Hoffmann, T.; Manhart, S.; Hoffmann, M.; Demuth, H.U.
Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions
FEBS Lett.
563
191-196
2004
Carica papaya, Homo sapiens
Schilling, S.; Niestroj, A.J.; Rahfeld, J.U.; Hoffmann, T.; Wermann, M.; Zunkel, K.; Wasternack, C.; Demuth, H.U.
Identification of human glutaminyl cyclase as a metalloenzyme. Potent inhibition by imidazole derivatives and heterocyclic chelators
J. Biol. Chem.
278
49773-49779
2003
Homo sapiens (Q16769), Homo sapiens
Huang, K.F.; Liu, Y.L.; Cheng, W.J.; Ko, T.P.; Wang, A.H.
Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation
Proc. Natl. Acad. Sci. USA
102
13117-13122
2005
Homo sapiens (Q16769), Homo sapiens
Booth, R.E.; Misquitta, S.A.; Bateman, R.C., Jr.
Human pituitary glutaminyl cyclase: expression in insect cells and dye affinity purification
Protein Expr. Purif.
32
141-146
2003
Bos taurus, Homo sapiens
Huang, K.F.; Liu, Y.L.; Wang, A.H.
Cloning, expression, characterization, and crystallization of a glutaminyl cyclase from human bone marrow: a single zinc metalloenzyme
Protein Expr. Purif.
43
65-72
2005
Homo sapiens
Schilling, S.; Cynis, H.; von Bohlen, A.; Hoffmann, T.; Wermann, M.; Heiser, U.; Buchholz, M.; Zunkel, K.; Demuth, H.U.
Isolation, catalytic properties, and competitive inhibitors of the zinc-dependent murine glutaminyl cyclase
Biochemistry
44
13415-13424
2005
Mus musculus (Q9CYK2), Mus musculus
Cynis, H.; Schilling, S.; Bodnar, M.; Hoffmann, T.; Heiser, U.; Saido, T.C.; Demuth, H.
Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells
Biochim. Biophys. Acta
1764
1618-1625
2006
Homo sapiens, Mus musculus
Guevara, T.; Mallorqui-Fernandez, N.; Garcia-Castellanos, R.; Garcia-Pique, S.; Ebert Petersen, G.; Lauritzen, C.; Pedersen, J.; Arnau, J.; Gomis-Rueth, F.X.; Sola, M.
Papaya glutamine cyclotransferase shows a singular five-fold beta-propeller architecture that suggests a novel reaction mechanism
Biol. Chem.
387
1479-1486
2006
Carica papaya (O81226), Carica papaya
Schilling, S.; Stenzel, I.; von Bohlen, A.; Wermann, M.; Schulz, K.; Demuth, H.U.; Wasternack, C.
Isolation and characterization of the glutaminyl cyclases from Solanum tuberosum and Arabidopsis thaliana: implications for physiological functions
Biol. Chem.
388
145-153
2007
Arabidopsis thaliana, Solanum tuberosum, Solanum tuberosum (M1AKD0)
Buchholz, M.; Heiser, U.; Schilling, S.; Niestroj, A.J.; Zunkel, K.; Demuth, H.U.
The first potent inhibitors for human glutaminyl cyclase: synthesis and structure-activity relationship
J. Med. Chem.
49
664-677
2006
Homo sapiens
Wintjens, R.; Belrhali, H.; Clantin, B.; Azarkan, M.; Bompard, C.; Baeyens-Volant, D.; Looze, Y.; Villeret, V.
Crystal structure of papaya glutaminyl cyclase, an archetype for plant and bacterial glutaminyl cyclases
J. Mol. Biol.
357
457-470
2006
Carica papaya (O81226), Carica papaya
Pawlak, J.; Manjunatha Kini, R.
Snake venom glutaminyl cyclase
Toxicon
48
278-286
2006
Boiga irregularis (A7ISW1), Boiga irregularis, Boiga dendrophila (A7ISW2), Boiga dendrophila
Huang, K.F.; Wang, Y.R.; Chang, E.C.; Chou, T.L.; Wang, A.H.
A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis
Biochem. J.
411
181-190
2008
Homo sapiens
Schilling, S.; Lindner, C.; Koch, B.; Wermann, M.; Rahfeld, J.U.; von Bohlen, A.; Rudolph, T.; Reuter, G.; Demuth, H.U.
Isolation and characterization of glutaminyl cyclases from Drosophila: evidence for enzyme forms with different subcellular localization
Biochemistry
46
10921-10930
2007
Drosophila melanogaster, Drosophila melanogaster (Q9VRQ9)
Cynis, H.; Scheel, E.; Saido, T.C.; Schilling, S.; Demuth, H.U.
Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-beta
Biochemistry
47
7405-7413
2008
Homo sapiens
Gontsarova, A.; Kaufmann, E.; Tumani, H.; Dressel, A.; Mandel, F.; Wiesmueller, K.H.; Kunert-Keil, C.; Brinkmeier, H.
Glutaminyl cyclase activity is a characteristic feature of human cerebrospinal fluid
Clin. Chim. Acta
389
152-159
2008
Homo sapiens
Cynis, H.; Rahfeld, J.U.; Stephan, A.; Kehlen, A.; Koch, B.; Wermann, M.; Demuth, H.U.; Schilling, S.
Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery
J. Mol. Biol.
379
966-980
2008
Homo sapiens
Schilling, S.; Appl, T.; Hoffmann, T.; Cynis, H.; Schulz, K.; Jagla, W.; Friedrich, D.; Wermann, M.; Buchholz, M.; Heiser, U.; von Hoersten, S.; Demuth, H.U.
Inhibition of glutaminyl cyclase prevents pGlu-Abeta formation after intracortical/hippocampal microinjection in vivo/in situ
J. Neurochem.
106
1225-1236
2008
Rattus norvegicus
Schilling, S.; Zeitschel, U.; Hoffmann, T.; Heiser, U.; Francke, M.; Kehlen, A.; Holzer, M.; Hutter-Paier, B.; Prokesch, M.; Windisch, M.; Jagla, W.; Schlenzig, D.; Lindner, C.; Rudolph, T.; Reuter, G.; Cynis, H.; Montag, D.; Demuth, H.U.; Rossner, S.
Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimers disease-like pathology
Nat. Med.
14
1106-1111
2008
Homo sapiens
Calvaresi, M.; Garavelli, M.; Bottoni, A.
Computational evidence for the catalytic mechanism of glutaminyl cyclase. A DFT investigation
Proteins
73
527-538
2008
Homo sapiens (Q16769)
Cornell, H.J.; Doherty, W.; Stelmasiak, T.
Papaya latex enzymes capable of detoxification of gliadin
Amino Acids
38
155-165
2009
Carica papaya, Carica papaya (O81226)
Seifert, F.; Schulz, K.; Koch, B.; Manhart, S.; Demuth, H.U.; Schilling, S.
Glutaminyl cyclases display significant catalytic proficiency for glutamyl substrates
Biochemistry
48
11831-11833
2009
Carica papaya, Homo sapiens, Mus musculus, Solanum tuberosum
Hook, V.; Schechter, I.; Demuth, H.U.; Hook, G.
Alternative pathways for production of beta-amyloid peptides of Alzheimers disease
Biol. Chem.
389
993-1006
2008
Rattus norvegicus
Stephan, A.; Wermann, M.; Von Bohlen, A.; Koch, B.; Cynis, H.; Demuth, H.; Schilling, S.
Mammalian glutaminyl cyclases and their isoenzymes have identical enzymatic characteristics
FEBS J.
276
6522-6536
2009
Homo sapiens, Mus musculus
Hartlage-Ruebsamen, M.; Staffa, K.; Waniek, A.; Wermann, M.; Hoffmann, T.; Cynis, H.; Schilling, S.; Demuth, H.U.; Rossner, S.
Developmental expression and subcellular localization of glutaminyl cyclase in mouse brain
Int. J. Dev. Neurosci.
27
825-835
2009
Mus musculus
Buchholz, M.; Hamann, A.; Aust, S.; Brandt, W.; Boehme, L.; Hoffmann, T.; Schilling, S.; Demuth, H.U.; Heiser, U.
Inhibitors for human glutaminyl cyclase by structure based design and bioisosteric replacement
J. Med. Chem.
52
7069-7080
2009
Homo sapiens (Q16769), Homo sapiens
Hartlage-Ruebsamen, M.; Morawski, M.; Waniek, A.; Jaeger, C.; Zeitschel, U.; Koch, B.; Cynis, H.; Schilling, S.; Schliebs, R.; Demuth, H.U.; Rossner, S.
Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Abeta deposits in hippocampus via distinct cellular mechanisms
Acta Neuropathol.
121
705-719
2011
Homo sapiens, Mus musculus
Bowser, T.E.; Trawick, M.L.
Probing the specificity of gamma-glutamylamine cyclotransferase: an enzyme involved in the metabolism of transglutaminase-catalyzed protein crosslinks
Amino Acids
44
143-150
2013
Oryctolagus cuniculus
Ruiz-Carrillo, D.; Koch, B.; Parthier, C.; Wermann, M.; Dambe, T.; Buchholz, M.; Ludwig, H.H.; Heiser, U.; Rahfeld, J.U.; Stubbs, M.T.; Schilling, S.; Demuth, H.U.
Structures of glycosylated mammalian glutaminyl cyclases reveal conformational variability near the active center
Biochemistry
50
6280-6288
2011
Homo sapiens (Q16769), Mus musculus (Q9CYK2)
Koch, B.; Kolenko, P.; Buchholz, M.; Ruiz Carrillo, D.; Parthier, C.; Wermann, M.; Rahfeld, J.U.; Reuter, G.; Schilling, S.; Stubbs, M.T.; Demuth, H.U.
Crystal structures of glutaminyl cyclases (QCs) from Drosophila melanogaster reveal active site conservation between insect and mammalian QCs
Biochemistry
51
7383-7392
2012
Drosophila melanogaster (Q86PD7), Drosophila melanogaster (Q9VRQ9), Drosophila melanogaster
Carrillo, D.R.; Parthier, C.; Jaenckel, N.; Grandke, J.; Stelter, M.; Schilling, S.; Boehme, M.; Neumann, P.; Wolf, R.; Demuth, H.U.; Stubbs, M.T.; Rahfeld, J.U.
Kinetic and structural characterization of bacterial glutaminyl cyclases from Zymomonas mobilis and Myxococcus xanthus
Biol. Chem.
391
1419-1428
2010
Myxococcus xanthus (Q1DDS6), Zymomonas mobilis (Q5NLA9)
Koch, B.; Buchholz, M.; Wermann, M.; Heiser, U.; Schilling, S.; Demuth, H.U.
Probing secondary glutaminyl cyclase (QC) inhibitor interactions applying an in silico-modeling/site-directed mutagenesis approach: implications for drug development
Chem. Biol. Drug Des.
80
937-946
2012
Homo sapiens (Q16769), Mus musculus (Q9CYK2)
Huang, K.F.; Liaw, S.S.; Huang, W.L.; Chia, C.Y.; Lo, Y.C.; Chen, Y.L.; Wang, A.H.
Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding
J. Biol. Chem.
286
12439-12449
2011
Homo sapiens, Homo sapiens (Q9NXS2)
Huang, W.L.; Wang, Y.R.; Ko, T.P.; Chia, C.Y.; Huang, K.F.; Wang, A.H.
Crystal structure and functional analysis of the glutaminyl cyclase from Xanthomonas campestris
J. Mol. Biol.
401
374-388
2010
Xanthomonas campestris (Q8P8M4), Xanthomonas campestris, Xanthomonas campestris ATCC 33913 (Q8P8M4)
Huang, K.F.; Hsu, H.L.; Karim, S.; Wang, A.H.
Structural and functional analyses of a glutaminyl cyclase from Ixodes scapularis reveal metal-independent catalysis and inhibitor binding
Acta Crystallogr. Sect. D
70
789-801
2014
Ixodes scapularis (B7QK46), Ixodes scapularis
Waniek, A.; Hartlage-Ruebsamen, M.; Hoefling, C.; Kehlen, A.; Schilling, S.; Demuth, H.U.; Rossner, S.
Identification of thyrotropin-releasing hormone as hippocampal glutaminyl cyclase substrate in neurons and reactive astrocytes
Biochim. Biophys. Acta
1852
146-155
2015
Mus musculus
Becker, A.; Eichentopf, R.; Sedlmeier, R.; Waniek, A.; Cynis, H.; Koch, B.; Stephan, A.; Baeuscher, C.; Kohlmann, S.; Hoffmann, T.; Kehlen, A.; Berg, S.; Freyse, E.J.; Osmand, A.; Plank, A.C.; Rossner, S.; von Hoersten, S.; Graubner, S.; Demuth, H.U.; Schilling, S.
IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes
Biol. Chem.
397
45-55
2016
Mus musculus
Seifert, F.; Demuth, H.U.; Weichler, T.; Ludwig, H.H.; Tittmann, K.; Schilling, S.
Phosphate ions and glutaminyl cyclases catalyze the cyclization of glutaminyl residues by facilitating synchronized proton transfers
Bioorg. Chem.
60
98-101
2015
Drosophila melanogaster
Adamson, S.W.; Browning, R.E.; Chao, C.C.; Bateman, R.C.; Ching, W.M.; Karim, S.
Molecular characterization of tick salivary gland glutaminyl cyclase
Insect Biochem. Mol. Biol.
43
781-793
2013
Ixodes scapularis (B7QK46), Ixodes scapularis, Amblyomma maculatum (G3MGU0)
Hoefling, C.; Indrischek, H.; Hoepcke, T.; Waniek, A.; Cynis, H.; Koch, B.; Schilling, S.; Morawski, M.; Demuth, H.U.; Rossner, S.; Hartlage-Ruebsamen, M.
Mouse strain and brain region-specific expression of the glutaminyl cyclases QC and isoQC
Int. J. Dev. Neurosci.
36
64-73
2014
Mus musculus
Cynis, H.; Funkelstein, L.; Toneff, T.; Mosier, C.; Ziegler, M.; Koch, B.; Demuth, H.U.; Hook, V.
Pyroglutamate-amyloid-beta and glutaminyl cyclase are colocalized with amyloid-beta in secretory vesicles and undergo activity-dependent, regulated secretion
Neurodegener. Dis.
14
85-97
2014
Bos taurus, Homo sapiens
Bridel, C.; Hoffmann, T.; Meyer, A.; Durieux, S.; Koel-Simmelink, M.A.; Orth, M.; Scheltens, P.; Lues, I.; Teunissen, C.E.
Glutaminyl cyclase activity correlates with levels of Abeta peptides and mediators of angiogenesis in cerebrospinal fluid of Alzheimers disease patients
Alzheimers Res. Ther.
9
38
2017
Homo sapiens (Q16769), Homo sapiens
Bender, P.; Egger, A.; Westermann, M.; Taudte, N.; Sculean, A.; Potempa, J.; Moeller, B.; Buchholz, M.; Eick, S.
Expression of human and Porphyromonas gingivalis glutaminyl cyclases in periodontitis and rheumatoid arthritis-A pilot study
Arch. Oral Biol.
97
223-230
2019
Porphyromonas gingivalis, Homo sapiens (Q16769), Homo sapiens (Q9NXS2), Homo sapiens
Li, M.; Dong, Y.; Yu, X.; Zou, Y.; Zheng, Y.; Bu, X.; Quan, J.; He, Z.; Wu, H.
Inhibitory effect of flavonoids on human glutaminyl cyclase
Bioorg. Med. Chem.
24
2280-2286
2016
Homo sapiens (Q16769), Homo sapiens
Ngo, V.T.H.; Hoang, V.H.; Tran, P.T.; Van Manh, N.; Ann, J.; Kim, E.; Cui, M.; Choi, S.; Lee, J.; Kim, H.; Ha, H.J.; Choi, K.; Kim, Y.H.; Lee, J.
Structure-activity relationship investigation of Phe-Arg mimetic region of human glutaminyl cyclase inhibitors
Bioorg. Med. Chem.
26
3133-3144
2018
Homo sapiens (Q16769), Homo sapiens
Wu, Z.; Weng, L.; Zhang, T.; Tian, H.; Fang, L.; Teng, H.; Zhang, W.; Gao, J.; Hao, Y.; Li, Y.; Zhou, H.; Wang, P.
Identification of glutaminyl cyclase isoenzyme isoQC as a regulator of SIRPalpha-CD47 axis
Cell Res.
29
502-505
2019
Homo sapiens (Q9NXS2)
Xu, A.; He, F.; Yu, C.; Qu, Y.; Zhang, Q.; Lv, J.; Zhang, X.; Ran, Y.; Wei, C.; Wu, J.
The development of small molecule inhibitors of glutaminyl cyclase and isoglutaminyl cyclase for Alzheimers disease
ChemistrySelect
4
10591-10600
2019
Homo sapiens (Q16769), Homo sapiens (Q9NXS2)
-
Schlenzig, D.; Cynis, H.; Hartlage-Ruebsamen, M.; Zeitschel, U.; Menge, K.; Fothe, A.; Ramsbeck, D.; Spahn, C.; Wermann, M.; Rossner, S.; Buchholz, M.; Schilling, S.; Demuth, H.U.
Dipeptidyl-peptidase activity of meprin beta links N-truncation of Abeta with glutaminyl cyclase-catalyzed pGlu-Abeta formation
J. Alzheimers Dis.
66
359-375
2018
Homo sapiens (Q16769), Homo sapiens
Pozzi, C.; Di Pisa, F.; Benvenuti, M.; Mangani, S.
The structure of the human glutaminyl cyclase-SEN177 complex indicates routes for developing new potent inhibitors as possible agents for the treatment of neurological disorders
J. Biol. Inorg. Chem.
23
1219-1226
2018
Homo sapiens (Q16769), Homo sapiens (Q9NXS2), Homo sapiens
Vijayasarathy, M.; Basheer, S.M.; Balaram, P.
Cone snail glutaminyl cyclase sequences from transcriptomic analysis and mass spectrometric characterization of two pyroglutamyl conotoxins
J. Proteome Res.
17
2695-2703
2018
Conus monile (A0A2D1P879), Conus monile, Conus litteratus (A0A2D1P881), Conus litteratus, Conus amadis (A0A2D1P884), Conus amadis, Conus miles (A0A2D1P885), Conus miles, Conus frigidus (A0A2D1P886), Conus frigidus, Conus araneosus (A0A2D1P8A3)
Hielscher-Michael, S.; Griehl, C.; Buchholz, M.; Demuth, H.U.; Arnold, N.; Wessjohann, L.A.
Natural products from microalgae with potential against Alzheimers disease sulfolipids are potent glutaminyl cyclase inhibitors
Mar. Drugs
14
203
2016
Homo sapiens (Q16769)
Hartlage-Ruebsamen, M.; Bluhm, A.; Piechotta, A.; Linnert, M.; Rahfeld, J.U.; Demuth, H.U.; Lues, I.; Kuhn, P.H.; Lichtenthaler, S.F.; Rossner, S.; Hoefling, C.
Immunohistochemical evidence from APP-transgenic mice for glutaminyl cyclase as drug target to diminish pE-Abeta formation
Molecules
23
924
2018
Mus musculus (Q9CYK2)
Logtenberg, M.E.W.; Jansen, J.H.M.; Raaben, M.; Toebes, M.; Franke, K.; Brandsma, A.M.; Matlung, H.L.; Fauster, A.; Gomez-Eerland, R.; Bakker, N.A.M.; van der Schot, S.; Marijt, K.A.; Verdoes, M.; Haanen, J.B.A.G.; van den Berg, J.H.; Neefjes, J.; van den Berg, T.K.; Brummelkamp, T.R.; Leusen, J.H.W.; Scheeren, F.A.; Schumacher, T.N.
Glutaminyl cyclase is an enzymatic modifier of the CD47-SIRPalpha axis and a target for cancer immunotherapy
Nat. Med.
25
612-619
2019
Homo sapiens (Q9NXS2)
Vijayan, D.K.; Zhang, K.Y.J.
Human glutaminyl cyclase Structure, function, inhibitors and involvement in Alzheimers disease
Pharmacol. Res.
147
104342
2019
Homo sapiens (Q16769), Homo sapiens (Q9NXS2), Homo sapiens
Tran, P.; Hoang, V.; Lee, J.; Hien, T.; Tung, N.; Ngo, S.
In vitro and in silico determination of glutaminyl cyclase inhibitors
RSC Adv.
9
29619-29627
2019
Homo sapiens (Q16769)
-
html completed
