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2.3.2.5: glutaminyl-peptide cyclotransferase

This is an abbreviated version!
For detailed information about glutaminyl-peptide cyclotransferase, go to the full flat file.

Word Map on EC 2.3.2.5

Reaction

L-glutaminyl-peptide
=
5-Oxoprolyl-peptide
+
NH3

Synonyms

AtQC, cyclotransferase, glutaminyl-transfer ribonucleate, DromeQC, gamma-glutamylamine cyclotransferase, GGACT, glutamine cyclotransferase, glutaminyl cyclase, glutaminyl-peptide cyclotransferase-like protein, glutaminyl-tRNA cyclotransferase, golgi resident enzyme, Golgi resident glutaminyl cyclase, Golgi-resident enzyme, Golgi-resident glutaminyl cyclase, gQC, h-isoQC, h-QC, hQC, isoDromeQC, isoGlutaminyl cyclase, isoQC, PgQC, QC, QCT, Qpct, Qpct1, QPCTL, secretory glutaminyl cyclase, sQC, StQC

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.2 Aminoacyltransferases
                2.3.2.5 glutaminyl-peptide cyclotransferase

KI Value

KI Value on EC 2.3.2.5 - glutaminyl-peptide cyclotransferase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.253
(3,4-dichlorophenyl)-2-cyano-3-(3-(5-methyl-1H-imidazol-1-yl)propyl)guanidine
-
0.62
(3-(1H-imidazol-1-yl)propyl)-2-cyano-3-(2,3-dihydrobenzo[b][1,4]dioxin-7-yl)guanidine
-
1.36
(3-(1H-imidazol-1-yl)propyl)-2-cyano-3-(3,4-dimethoxyphenyl)guanidine
-
6.72
(3-(1H-imidazol-1-yl)propyl)-2-cyano-3-(4-(trifluoromethyl)phenyl)guanidine
-
0.83
(3-(1H-imidazol-1-yl)propyl)-2-cyano-3-(4-isopropylphenyl)guanidine
-
0.7
(3-(1H-imidazol-1-yl)propyl)-2-cyano-3-(4-methoxyphenyl)guanidine
-
1.37
(3-(1H-imidazol-1-yl)propyl)-2-cyano-3-(cyclopropylmethyl)guanidine
-
1.53
(3-(1H-imidazol-1-yl)propyl)-2-cyano-3-methylguanidine
-
1.02
(3-(1H-imidazol-1-yl)propyl)-2-cyano-3-phenylguanidine
-
1.09
(3-(1H-imidazol-1-yl)propyl)-3-(4-bromophenyl)-2-cyanoguanidine
-
1.65
(3-(4-methyl-1H-imidazol-1-yl)propyl)-2-cyano-3-(2,3-dihydrobenzo[b][1,4]dioxin-7-yl)guanidine
-
0.13
(3-(5-methyl-1H-imidazol-1-yl)propyl)-2-cyano-3-(2,3-dihydrobenzo[b][1,4]dioxin-7-yl)guanidine
-
0.00345
1,10-phenanthroline
at pH 8.0 and 25°C
0.295
1,4-bis-(imidazol-1-yl)methyl-2,5-dimethylbenzene
30°C, pH 8.0
0.00112
1-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea
-
pH 8.0, 30°C
0.00056
1-(2,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea
-
pH 8.0, 30°C
0.184
1-(2-oxo-2-phenylethyl)-imidazole
30°C, pH 8.0
0.00155
1-(3,4-dimethoxybenzyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea
-
pH 8.0, 30°C
0.00233
1-(3,4-dimethoxyphenyl)-3-(2-[1-(1H-imidazol-1-yl)cyclopropyl]ethyl)thiourea
-
pH 8.0, 30°C
0.06
1-(3,4-dimethoxyphenyl)-3-(3-(4-methyl-1H-imidazol-1-yl)propyl)thiourea
-
0.0063
1-(3,4-dimethoxyphenyl)-3-(3-(5-methyl-1H-imidazol-1-yl)propyl)thiourea
-
0.00034
1-(3,4-dimethoxyphenyl)-3-[(3R)-3-(1H-imidazol-1-yl)butyl]thiourea
-
pH 8.0, 30°C
0.00076
1-(3,4-dimethoxyphenyl)-3-[(3S)-3-(1H-imidazol-1-yl)butyl]thiourea
-
pH 8.0, 30°C
0.00006
1-(3,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea
-
pH 8.0, 30°C
0.00049
1-(3,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]urea
-
pH 8.0, 30°C
0.00055
1-(3,4-dimethoxyphenyl)-3-[4-(1H-imidazol-1-yl)butyl]thiourea
-
pH 8.0, 30°C
0.041
1-(3,4-dimethoxyphenyl)-N-(3-(4-methyl-1H-imidazol-1-yl)propyl)cyclopropanecarbothioamide
-
0.0026
1-(3,4-dimethoxyphenyl)-N-(3-(5-methyl-1H-imidazol-1-yl)propyl)cyclopropanecarbothioamide
-
0.00075
1-(3,5-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea
-
pH 8.0, 30°C
0.41
1-(3-aminopropyl)-imidazole
30°C, pH 8.0
0.0018
1-(4-acetylphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea
-
pH 8.0, 30°C
0.00089
1-(4-ethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea
-
pH 8.0, 30°C
0.0028
1-(4-ethylphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea
-
pH 8.0, 30°C
0.0062
1-(6-phenoxyhexyl)-1H-imidazole
-
0.000262 - 0.114
1-Benzylimidazole
0.12
1-methyl-5-(beta-aminoethyl)-imidazole
30°C, pH 8.0
0.000101 - 0.109
1-Methylimidazole
0.049
1-vinylimidazole
30°C, pH 8.0
0.0028
1-[3-(1H-imidazol-1-yl)propyl]-3-(1-naphthyl)thiourea
-
pH 8.0, 30°C
0.00034
1-[3-(1H-imidazol-1-yl)propyl]-3-(3,4,5-trimethoxyphenyl)thiourea
-
pH 8.0, 30°C
0.00186
1-[3-(1H-imidazol-1-yl)propyl]-3-(3-methoxyphenyl)thiourea
-
pH 8.0, 30°C
0.0007
1-[3-(1H-imidazol-1-yl)propyl]-3-(4-methoxyphenyl)thiourea
-
pH 8.0, 30°C
0.00214
1-[3-(1H-imidazol-1-yl)propyl]-3-(4-methylphenyl)thiourea
-
pH 8.0, 30°C
0.00166
1-[3-(1H-imidazol-1-yl)propyl]-3-[4-(methylthio)phenyl]thiourea
-
pH 8.0, 30°C
0.00097
1-[4-(benzyloxy)phenyl]-3-[3-(1H-imidazol-1-yl)propyl]thiourea
-
pH 8.0, 30°C
0.23
2,3-dihydro-3-(3-(4-methyl-1H-imidazol-1-yl)propyl)-2-thioxoquinazolin-4(1H)-one
-
0.018
2,3-dihydro-3-(3-(5-methyl-1H-imidazol-1-yl)propyl)-2-thioxoquinazolin-4(1H)-one
-
0.083
2,3-dihydro-6-methyl-3-(3-(5-methyl-1H-imidazol-1-yl)propyl)-5-phenyl-2-thioxothieno[2,3-d]pyrimidin-4(1H)-one
-
1.8
2-aminobenzimidazole
30°C, pH 8.0
0.061
2-cyano(3,4,5-trimethoxyphenyl)-3-(3-(5-methyl-1H-imidazol-1-yl)propyl)guanidine
-
0.082
2-cyano(3-(5-methyl-1H-imidazol-1-yl)propyl)-3-(3,4-dimethylphenyl)guanidine
-
0.065
2-cyano-1-[3-(5-methyl-1H-imidazol-1-yl)propyl]-4-phenylbenzene-1-guanidine
-
0.58
2-ethyl-4-methyl-imidazole
30°C, pH 8.0
2.58
2-mercaptoethanol
-
0.165
2-methyl-benzylimidazole
30°C, pH 8.0
0.3
3-(3-(1H-imidazol-1-yl)propyl)-2,3-dihydro-2-thioxoquinazolin-4(1H)-one
-
0.36
3-(3-(1H-imidazol-1-yl)propyl)-2,3-dihydro-7-methyl-2-thioxothieno[3,2-d]pyrimidin-4(1H)-one
-
0.62
3-[3-(1H-imidazol-1-yl)propyl]-2-thioxo-1,2,3,5,6,7-hexahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one
-
0.9
3-[3-(1H-imidazol-1-yl)propyl]-2-thioxo-2,3,5,6,7,8,9,10-octahydrocycloocta[4,5]thieno[2,3-d]pyrimidin-4(1H)-one
-
0.34
3-[3-(1H-imidazol-1-yl)propyl]-2-thioxo-2,3,5,6,7,8-hexahydro[1]benzothieno[2,3-d]pyrimidin-4(1H)-one
-
0.818
3-[3-(1H-imidazol-1-yl)propyl]-2-thioxoimidazolidin-4-one
30°C, pH 8.0
0.039
3-[3-(5-methyl-1H-imidazol-1-yl)propyl]-2-thioxo-2,3,5,6,7,8,9,10-octahydrocycloocta[4,5]-thieno[2,3-d]pyrimidin-4(1H)-one
-
0.017
3-[3-(5-methyl-1H-imidazol-1-yl)propyl]-2-thioxo-2,3,5,6,7,8-hexahydro[1]benzothieno[2,3-d]pyrimidin-4(1H)-one
-
0.0023
4-(2-imidazol-1-yl-ethoxy)-benzoic acid
30°C, pH 8.0
7.6
4-imidazole-carboxaldehyde
30°C, pH 8.0
0.073
4-methylimidazole
pH 8
0.000023
5-(5-[[(3,4-dimethoxyphenyl)sulfanyl]methyl]-1,3,4-oxadiazol-2-yl)-1H-benzimidazole
pH and temperature not specified in the publication
0.00101
5-(5-[[(pyridin-4-yl)methyl]sulfanyl]-1,3,4-oxadiazol-2-yl)-1H-benzimidazole
pH and temperature not specified in the publication
15.5
5-amino-3H-imidazole-4-carboxylic acid amide
30°C, pH 8.0
0.129
5-hydroxymethyl-4-methyl-imidazole
30°C, pH 8.0
0.000638
5-[5-(2-phenylethyl)-1,3,4-oxadiazol-2-yl]-1H-benzimidazole
pH and temperature not specified in the publication
0.02
6-benzyl-2,3-dihydro-3-(3-(5-methyl-1H-imidazol-1-yl)propyl)-2-thioxothieno[2,3-d]pyrimidin-4(1H)-one
-
0.017 - 2.188
benzimidazole
0.0035 - 0.0073
benzylimidazole
1.824 - 6.696
cacodylate
0.042 - 0.301
cysteamine
0.0368
dipicolinic acid
at pH 8.0 and 25°C
3.25 - 35.75
EFRH-NH2
4.69 - 10.4
EFRHHDSGYE-NH2
19.3
ethanolamine
-
22
ethylenediamine
-
0.97 - 1.33
Gln-tert-butyl ester
4.5 - 5.73
H-Gln-7-amido-4-methylcoumarin
1.3 - 1.47
H-Gln-beta-naphthylamide
0.6
H-His-Trp-OH
30°C, pH 8.0
14.5
imidazol-4-carbonic acid methylester
30°C, pH 8.0
0.103 - 1.141
imidazole
1.54 - 5.06
L-Gln-2-naphthylamide
4.47
L-glutaminyl-7-amido-4-methylcoumarin
-
protein version: shortened N-terminus, I73N/C369A, His-tagged, pH 8.0, 30°C, similar value with other protein versions
1.57 - 3.55
L-glutaminyl-beta-naphthylamide
0.85
L-histamine
30°C, pH 8.0
0.56
L-histidinamide
30°C, pH 8.0
4.4
L-histidine
30°C, pH 8.0
1.53
L-histidinol
30°C, pH 8.0
0.023 - 0.082
methylimidazole
0.027
N,N-dimethylcysteamine
-
protein expressed in Pichia pastoris, pH 8.0, 30°C
0.051
N-(-1-(3-(5-methyl-1H-imidazol-1-yl)propylamino)-2-nitrovinyl)-4-chloro-benzenamine
-
0.54
N-(1-(3-(1H-imidazol-1-yl)propylamino)-2-nitrovinyl)-2,3-dihydrobenzo[b][1,4]-dioxin-6-amine
-
0.61
N-(1-(3-(1H-imidazol-1-yl)propylamino)-2-nitrovinyl)-3,4-dimethoxy-benzenamine
-
0.54
N-(1-(3-(1H-imidazol-1-yl)propylamino)-2-nitrovinyl)-4-(trifluoromethyl)-benzenamine
-
0.57
N-(1-(3-(1H-imidazol-1-yl)propylamino)-2-nitrovinyl)-4-chlorobenzenamine
-
1.03
N-(1-(3-(1H-imidazol-1-yl)propylamino)-2-nitrovinyl)-4-methoxybenzenamine
-
1.17
N-(1-(3-(1H-imidazol-1-yl)propylamino)-2-nitrovinyl)benzenamine
-
0.52
N-(1-(3-(1H-imidazol-1-yl)propylamino)-2-nitrovinyl)naphthalen-1-amine
-
1.29
N-(1-(3-(4-methyl-1H-imidazol-1-yl)propylamino)-2-nitrovinyl)-2,3-dihydrobenzo[b][1,4]-dioxin-6-amine
-
0.067
N-(1-(3-(5-methyl-1H-imidazol-1-yl)propylamino)-2-nitrovinyl)-2,3-dihydrobenzo[b][1,4]-dioxin-6-amine
-
0.034
N-(1-(3-(5-methyl-1H-imidazol-1-yl)propylamino)-2-nitrovinyl)-4-(trifluoromethyl)benzenamine
-
0.044
N-(1-(3-(5-methyl-1H-imidazol-1-yl)propylamino)-2-nitrovinyl)cyclohexanamine
-
0.042
N-(1-(3-(5-methyl-1H-imidazol-1-yl)propylamino)-2-nitrovinyl)naphthalen-1-amine
-
0.000006
N-(3,4-dimethoxyphenyl)-N'-[3-(1H-imidazol-1-yl)propyl]thiourea
pH and temperature not specified in the publication
0.5
N-(3-(1H-imidazol-1-yl)propyl)-N-cyclohexyl-2-nitroethene-1,1-diamine
-
20.55
N-(3-(1H-imidazol-1-yl)propyl)-N-methyl-2-nitroethene-1,1-diamine
-
0.0012
N-(4-chlorophenyl)-N'-[2-(1H-imidazol-1-yl)propyl]-2-thioxoimidazolidin-4-one
30°C, pH 8.0
0.00124
N-(4-chlorophenyl)-N'-[3-(1H-imidazol-1-yl)propyl]thiourea
pH and temperature not specified in the publication
0.167
N-(trimethylsilyl)-imidazole
30°C, pH 8.0
0.107
N-Acetylimidazole
30°C, pH 8.0
0.174
N-benzoylimidazole
30°C, pH 8.0
0.0109 - 0.405
N-diethylcysteamine
0.022 - 0.08
N-dimethylcysteamine
0.013
N-methylimidazole
-
pH 8.0, 30°C
0.017 - 0.827
N-omega-acetylhistamine
0.002
N-[3-(1H-imidazol-1-yl)propyl]-5-methoxy-1,3-benzothiazol-2-amine
-
pH 8.0, 30°C
0.00157
N-[3-(1H-imidazol-1-yl)propyl]-6-methoxy-1,3-benzothiazol-2-amine
-
pH 8.0, 30°C
0.001698 - 0.0142
Nomega-acetylhistamine
0.078
oxalic acid diimidazolidide
30°C, pH 8.0
0.000097 - 0.145
P150/03
-
0.000095 - 0.003139
PBD150
0.00002
SEN177
pH 8.0, 25°C, with enzyme mutant Y115E/Y117E
additional information
additional information
-