2.3.2.5: glutaminyl-peptide cyclotransferase
This is an abbreviated version!
For detailed information about glutaminyl-peptide cyclotransferase, go to the full flat file.
Word Map on EC 2.3.2.5
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2.3.2.5
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pyroglutamate
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alzheimer
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cyclases
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pyroglutamyl
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papaya
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pyroglutamate-modified
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pglu-a
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medicine
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drug development
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antivenomics
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pharmacology
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n-truncated
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cd47-sirp
- 2.3.2.5
- pyroglutamate
- alzheimer
- cyclases
-
pyroglutamyl
- papaya
-
pyroglutamate-modified
-
pglu-a
- medicine
- drug development
-
antivenomics
- pharmacology
-
n-truncated
-
cd47-sirp
Reaction
Synonyms
AtQC, cyclotransferase, glutaminyl-transfer ribonucleate, DromeQC, gamma-glutamylamine cyclotransferase, GGACT, glutamine cyclotransferase, glutaminyl cyclase, glutaminyl-peptide cyclotransferase-like protein, glutaminyl-tRNA cyclotransferase, golgi resident enzyme, Golgi resident glutaminyl cyclase, Golgi-resident enzyme, Golgi-resident glutaminyl cyclase, gQC, h-isoQC, h-QC, hQC, isoDromeQC, isoGlutaminyl cyclase, isoQC, PgQC, QC, QCT, Qpct, Qpct1, QPCTL, secretory glutaminyl cyclase, sQC, StQC
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Localization
Localization on EC 2.3.2.5 - glutaminyl-peptide cyclotransferase
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exclusively localized within the Golgi complex, obviously retained by the N-terminus. Retention in the Golgi complex suggests involvement in the protein maturation machinery
unlike QC, the secreted isozyme, isozyme isoQC exclusively localizes within the Golgi complex via a transmembrane domain
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a 40000 Da enzyme form is exclusively detected in soluble pituitary extract, a 32000 Da enzyme form is detected in soluble fraction of all tissues which show immunoreactivity. The difference in the two immunoreacive proteins lies in the proteolytic cleavage within a hydrophilic region approximately 80 amino acids from the carboxy-terminus
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