2.3.2.5: glutaminyl-peptide cyclotransferase
This is an abbreviated version!
For detailed information about glutaminyl-peptide cyclotransferase, go to the full flat file.
Word Map on EC 2.3.2.5
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2.3.2.5
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pyroglutamate
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alzheimer
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cyclases
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pyroglutamyl
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papaya
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pyroglutamate-modified
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pglu-a
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medicine
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drug development
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antivenomics
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pharmacology
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n-truncated
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cd47-sirp
- 2.3.2.5
- pyroglutamate
- alzheimer
- cyclases
-
pyroglutamyl
- papaya
-
pyroglutamate-modified
-
pglu-a
- medicine
- drug development
-
antivenomics
- pharmacology
-
n-truncated
-
cd47-sirp
Reaction
Synonyms
AtQC, cyclotransferase, glutaminyl-transfer ribonucleate, DromeQC, gamma-glutamylamine cyclotransferase, GGACT, glutamine cyclotransferase, glutaminyl cyclase, glutaminyl-peptide cyclotransferase-like protein, glutaminyl-tRNA cyclotransferase, golgi resident enzyme, Golgi resident glutaminyl cyclase, Golgi-resident enzyme, Golgi-resident glutaminyl cyclase, gQC, h-isoQC, h-QC, hQC, isoDromeQC, isoGlutaminyl cyclase, isoQC, PgQC, QC, QCT, Qpct, Qpct1, QPCTL, secretory glutaminyl cyclase, sQC, StQC
ECTree
2.3.2.5 glutaminyl-peptide cyclotransferaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.3.2.5 - glutaminyl-peptide cyclotransferase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-glutaminyl-Abeta(3-42) peptide
5-oxoprolyl-Abeta(3-42) peptide + NH3
a glutamate residue (E) is exposed at position 3 of Abeta(3-42) and can be converted by the enzymatic activity of glutaminyl cyclase (QC) to pE resulting in the peptide pE-Abeta(3-42). 5-Oxoproline ring formation under liberation of water. Slow conversion of N-terminal glutamate under slightly acidic pH conditions, as compared with the much faster pE formation from N-terminal glutamine
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?
L-glutaminyl-Abeta3-40/42
5-oxoprolyl-Abeta3-40/42 + NH3
amyloid-beta peptide Abeta3-40/42
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r
L-glutaminyl-Abeta3-40/42 peptide
5-oxoprolyl-Abeta3-40/42 peptide + NH3
amyloid-beta peptide Abeta3-40/42
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?
L-glutaminyl-CCL2
5-oxoprolyl-CCL2 + NH3
i.e. monocyte chemoattractant protein (MCP-1)
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r
L-glutaminyl-peptide
5-oxoprolyl-peptide + NH3
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the enzyme may participate in the posttranslational processing of hormonal precursors to pyroglutamyl peptides
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?
L-glutaminyl-peptide
5-oxoprolyl-peptide + NH3
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involved in posttranslational modification of the N-terminal glutamine of peptide hormones or neurotransmitters, such as thyrotropin releasing hormone, luteinizing hormone releasing hormone, gastrin, heavy chain of gamma-globulin
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?
L-glutaminyl-peptide
5-oxoprolyl-peptide + NH3
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the N-terminal formation of 5-oxoproline is a common post-translational event during biosynthesis of a number of peptides
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?
L-glutaminyl-peptide
5-oxoprolyl-peptide + NH3
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involved in posttranslational modification of the N-terminal glutamine of peptide hormones or neurotransmitters, such as thyrotropin releasing hormone, luteinizing hormone releasing hormone, gastrin, heavy chain of gamma-globulin
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?
L-glutaminyl-peptide
5-oxoprolyl-peptide + NH3
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involved in posttranslational modification of the N-terminal glutamine of peptide hormones or neurotransmitters, such as thyrotropin releasing hormone, luteinizing hormone releasing hormone, gastrin, heavy chain of gamma-globulin
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?
L-glutaminyl-peptide
5-oxoprolyl-peptide + NH3
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involved in posttranslational modification of the N-terminal glutamine of peptide hormones or neurotransmitters, such as thyrotropin releasing hormone, luteinizing hormone releasing hormone, gastrin, heavy chain of gamma-globulin
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?
additional information
?
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enzyme is involved in N-terminal pyroglutamate formation of snake venom toxins
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?
additional information
?
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enzyme is involved in N-terminal pyroglutamate formation of snake venom toxins
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?
additional information
?
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enzyme is involved in N-terminal pyroglutamate formation of snake venom toxins
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?
additional information
?
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enzyme is involved in N-terminal pyroglutamate formation of snake venom toxins
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?
additional information
?
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the enzyme may play a key role in posttranslational modification
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?
additional information
?
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the enzyme may play a key role in posttranslational modification
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?
additional information
?
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enzyme is important during cellular maturation of L-pyroglutamyl-containing peptides
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?
additional information
?
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orexin A, gastrin, gonadotropin, TRH, MCP-1 to 4, FPP, fibronectin, and neurotensin are substrates of the enzyme
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additional information
?
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enzyme is important during cellular maturation of L-pyroglutamyl-containing peptides
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?
