2.1.1.260: rRNA small subunit pseudouridine methyltransferase Nep1

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For detailed information about rRNA small subunit pseudouridine methyltransferase Nep1, go to the full flat file.

Reaction

Synonyms

Bowen-Conradi syndrome protein, Emg1, Emg1p, essential for mitotic growth 1, N1-specific pseudouridine methyltransferase, Nep1, Nep1 methyltransferase, Nep1p, nucleolar essential protein 1, pseudouridine N1-methyltransferase, pseudouridine-N1-specific methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.260 rRNA small subunit pseudouridine methyltransferase Nep1

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Results	in table
44	AA Sequence
10	Cloned(Commentary)
10	Cofactor
3	Crystallization (Commentary)
1	Expression
35	General Information
1	Inhibitors
12	Localization
2	Molecular Weight [Da]
12	Natural Substrates/ Products (Substrates)
17	Organism
1	Pathway
51	PDB ID
4	pH Optimum
10	Protein Variants
8	Purification (Commentary)
1	Reaction
16	Reference
1	Source Tissue
21	Substrates and Products (Substrate)
9	Subunits
56	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 2.1.1.260 - rRNA small subunit pseudouridine methyltransferase Nep1

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SYSTEMATIC NAME

IUBMB Comments

S-adenosyl-L-methionine:18S rRNA (pseudouridine1191-N1)-methyltransferase

This enzyme, which occurs in both prokaryotes and eukaryotes, recognizes specific pseudouridine residues (Psi) in small subunits of ribosomal RNA based on the local RNA structure. It recognizes Psi914 in 16S rRNA from the archaeon Methanocaldococcus jannaschii, Psi1191 in yeast 18S rRNA, and Psi1248 in human 18S rRNA.