2.1.1.260: rRNA small subunit pseudouridine methyltransferase Nep1

This is an abbreviated version!
For detailed information about rRNA small subunit pseudouridine methyltransferase Nep1, go to the full flat file.

Word Map on EC 2.1.1.260

2.1.1.260

rrnas

jannaschii

methanocaldococcus

nucleolus

hypermodified

s-adenosylmethionine

archaea

three-hybrid

rna-binding

Reaction

N1-methylpseudouridine1191 in yeast 18S rRNA

Synonyms

Bowen-Conradi syndrome protein, Emg1, Emg1p, essential for mitotic growth 1, N1-specific pseudouridine methyltransferase, Nep1, Nep1 methyltransferase, Nep1p, nucleolar essential protein 1, pseudouridine N1-methyltransferase, pseudouridine-N1-specific methyltransferase

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.260 rRNA small subunit pseudouridine methyltransferase Nep1

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Results	in table
44	AA Sequence
10	Cloned(Commentary)
10	Cofactor
3	Crystallization (Commentary)
1	Expression
35	General Information
1	Inhibitors
12	Localization
2	Molecular Weight [Da]
12	Natural Substrates/ Products (Substrates)
17	Organism
1	Pathway
51	PDB ID
4	pH Optimum
10	Protein Variants
8	Purification (Commentary)
1	Reaction
16	Reference
1	Source Tissue
21	Substrates and Products (Substrate)
9	Subunits
56	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]

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Reference on EC 2.1.1.260 - rRNA small subunit pseudouridine methyltransferase Nep1

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719322

Eschrich, D.; Buchhaupt, M.; Koetter, P.; Entian, K.D.

Nep1p (Emg1p), a novel protein conserved in eukaryotes and archaea, is involved in ribosome biogenesis

Curr. Genet.

326-338

2002

Saccharomyces cerevisiae, Homo sapiens, [Candida] glabrata (Q96UP2), Candida albicans (Q9P8P7), Candida albicans, [Candida] glabrata CBS 138 (Q96UP2), Saccharomyces cerevisiae CEN.PK2, Candida albicans RM1000 (Q9P8P7)

11935223

720579

Taylor, A.B.; Meyer, B.; Leal, B.Z.; Koetter, P.; Schirf, V.; Demeler, B.; Hart, P.J.; Entian, K.D.; Woehnert, J.

The crystal structure of Nep1 reveals an extended SPOUT-class methyltransferase fold and a pre-organized SAM-binding site

Nucleic Acids Res.

1542-1554

2008

Methanocaldococcus jannaschii (Q57977), Methanocaldococcus jannaschii DSM 2661 (Q57977)

18208838

720582

Wurm, J.; Meyer, B.; Bahr, U.; Held, M.; Frolow, O.; Koetter, P.; Engels, J.; Heckel, A.; Karas, M.; Entian, K.; Woehnert, J.

The ribosome assembly factor Nep1 responsible for Bowen-Conradi syndrome is a pseudouridine-N1-specific methyltransferase

Nucleic Acids Res.

2387-2398

2010

Homo sapiens, Methanocaldococcus jannaschii

20047967

720587

Meyer, B.; Wurm, J.P.; Koetter, P.; Leisegang, M.S.; Schilling, V.; Buchhaupt, M.; Held, M.; Bahr, U.; Karas, M.; Heckel, A.; Bohnsack, M.T.; Woehnert, J.; Entian, K.D.

The Bowen-Conradi syndrome protein Nep1 (Emg1) has a dual role in eukaryotic ribosome biogenesis, as an essential assembly factor and in the methylation of psi1191 in yeast 18S rRNA

Nucleic Acids Res.

1526-1537

2011

Homo sapiens, Saccharomyces cerevisiae

20972225

720589

Thomas, S.R.; Keller, C.A.; Szyk, A.; Cannon, J.R.; Laronde-Leblanc, N.A.

Structural insight into the functional mechanism of Nep1/Emg1 N1-specific pseudouridine methyltransferase in ribosome biogenesis

Nucleic Acids Res.

2445-2457

2011

Saccharomyces cerevisiae, Archaeoglobus fulgidus (O29524)

21087996

721118

Schilling, V.; Peifer, C.; Buchhaupt, M.; Lamberth, S.; Lioutikov, A.; Rietschel, B.; Koetter, P.; Entian, K.D.

Genetic interactions of yeast NEP1 (EMG1), encoding an essential factor in ribosome biogenesis

Yeast

167-183

2012

Saccharomyces cerevisiae

22588997