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NOX1
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NOX4
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NOX2
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NOX4
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Burkholderia cenocepacia resides in macrophage vacuoles displaying an altered recruitment of the NADPH oxidase complex at the phagosomal membrane
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after Fcgamma receptor-induced phagocytosis, yellow fluorescent protein-tagged subunits p67phox and p40phox translocate to granulocyte phagosomes before phagosome internalization and accumulation of a probe for phosphoinositol 3-phosphate. p67phox and p47phox accumulation on nascent and internalized phagosomes does not require p40phox or PI3 kinase activity. Translocation of p40phox to nascent phagosomes requires binding to p67phox but not phosphoinositol 3-phosphate
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synaptic and extrasynaptic areas of the plasmalemma, localization of subunit p47phox, in dorsomedial nucleus tractus solitarius neurons of saline-treated animals. Chronic administration of phenylephrine, which produces increases in systolic blood pressure, is associated with a repartitioning of p47phox immunolabeling away from intracellular organelles in distal dendritic areas, and toward the plasma membrane of intermediate dendritic areas of dorsomedial nucleus tractus solitarius neurons
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local production of superoxide anion, which is increased by M1-receptor agonist, oxotremorine and Ca2+ ionophore, A23187, increased. Inhibitors diphenylene iodonium and apocynin, or superoxide dismutase and catalase, and subunit Nox4 siRNA all substantially block this local production of superoxide anion. Sarcoplasmic superoxide anion producing system is controlled by cADPR-RyR/Ca2+ signaling pathway
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in resting cells, enzyme complex components p22phox and gp91phox are located in the plasma membrane and membranes of specific granules
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critical role for granules as a site for assembly and activation of the oxidase enzyme system
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NOX4
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seven transmembrane regions found
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minor part of protein is expressed at cell surface, not found at surface of transfected CHO and PLB-XCGD cells
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major part of protein
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full-length subunit p40phox exhibits a cytoplasmic localization pattern in resting cells. Upon stimulation with phorbol 12-myristate 13-acetate or formyl-Met-Leu-Phe, p40phox translocates to plasma membrane in a p67phox- and p47phox-dependent manner
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NOX4
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NOX components are distributed between the cytosol (p47phox, p67phox, p40phox and Rac1/2) and the plasma membrane and membranes of specific granules
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in resting cells, enzyme complex components p47phox, p67phox, p40phox and Rac1/2 are localized in the cytosol
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expression of cytosolic subunits of NAD(P)H oxidase p47phox and p67phox is not altered by hypercholesterolemia
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partially glycosylated isoform Duox2
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NOX4
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subunit p47phox, in dorsomedial nucleus tractus solitarius neurons of saline-treated animals. Administration of angiotensin over 7 days, which produces elevated systemic blood pressure, is associated with a redistribution of p47phox immunolabeling away from intracellular organelles in the distal dendritic compartment, and toward non-vesicular targets in less distal, intermediate areas of dorsomedial nucleus tractus solitarius neurons. Chronic administration of phenylephrine, which produces increases in systolic blood pressure, is associated with a repartitioning of p47phox immunolabeling away from intracellular organelles in distal dendritic areas, andtoward the plasma membrane of intermediate dendritic areas of dorsomedial nucleus tractus solitarius neurons
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partially glycosylated isoform Duox2
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NOX1, Nox1 stimulation in endosomes is dependent on ClC-3, where this ion exchanger is required to balance the electrogenic activity of the enzyme
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subunit gp91-phox of cytochrome b558 of the multicomponent complex is an integral membrane protein with several membrane-spanning regions
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active subunit Nox1 endogenously co-localizes with its regulatory components p22phox, NOXO1, NOXA1 and Rac1
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small GTPase Rac is involved in membrane translocation of subunit p67phox
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the electron current depolarises the neutrophil plasma membrane at a rate of 2.3 V per s and this depolarisation is opposed when voltage-gated proton channels are activated. 3 mM ZnCl2 depolarises the membrane potential to +97.8 mV , and this depolarisation is abolished after NADPH oxidase inhibition
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NOX components are distributed between the cytosol (p47phox, p67phox, p40phox and Rac1/2) and the plasma membrane and membranes of specific granules
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Nox1, like Nox2, associates with p22phox to form a membrane-bound cytochrome
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different membrane fractions enriched either in transversal tubules, triads containing transverse tubules attached to sarcoplasmic reticulum vesicles, and junctional sarcoplasmic reticulum vesicles. Enzyme subunits gp91phox, p47phox, p67phox, p22phox are enriched in transversal tubules and triads, but not in sarcoplasmic reticulum
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exposure to taxol induces translocation of p47phox protein to the membrane in cortical cultures
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NOX4
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full-length subunit p40phox exhibits a cytoplasmic localization pattern in resting cells. Upon stimulation with phorbol 12-myristate 13-acetate or formyl-Met-Leu-Phe, p40phox translocates to plasma membrane in a p67phox- and p47phox-dependent manner
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in resting cells, enzyme complex components p22phox and gp91phox are located in the plasma membrane and membranes of specific granules
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NOX1, NOX5, NOX2, and NOX4. The signal peptide at the N-terminus of Nox1 is important for localization at the plasma membrane, as it is prevented by replacement with the N-terminus of Nox4. A polybasic region in Nox5 with affinity for phosphoinositides may favor translocation to the plasma membrane and extracellular superoxide release
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additional information
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coexpression of enzyme and enzyme maturation factor DuoxA2 allows ER-to-Golgi transition, maturation, and translocation to the plasma membrane of functional isoform Duox2 in a heterologous system
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additional information
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in resting cells, enzyme complex components p47phox, p67phox, p40phox and Rac1/2 are localized in the cytosol, whereas p22phox and gp91phox are located in the plasma membrane and membranes of specific granules
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additional information
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Nox4 location varies according to cell type, different Nox4 isoforms may be present in specific subcellular locations
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