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Literature summary for 1.6.3.1 extracted from

  • Muller, G.; Morawietz, H.
    Nitric oxide, NAD(P)H oxidase, and atherosclerosis (2009), Antioxid. Redox Signal., 11, 1711-1731.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood vessel wall
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD(P)H + H+ + O2 NAD(P)H oxidase transfers electrons across membranes to oxygen and generate superoxide anions which rapidly dismutate to hydrogen peroxide Homo sapiens NAD(P)+ + H2O2
-
?

Cofactor

Cofactor Comment Organism Structure
FAD
-
Homo sapiens

General Information

General Information Comment Organism
physiological function NAD(P)H oxidase-derived reactive oxygen species play a role in the development and progression of atherosclerosis Homo sapiens