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Literature summary for 1.6.3.1 extracted from

  • Glass, M.J.; Chan, J.; Frys, K.A.; Oselkin, M.; Tarsitano, M.J.; Iadecola, C.; Pickel, V.M.
    Changes in the subcellular distribution of NADPH oxidase subunit p47phox in dendrites of rat dorsomedial nucleus tractus solitarius neurons in response to chronic administration of hypertensive agents (2007), Exp. Neurol., 205, 383-395.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine chronic administration of agents that induce hypertension can also produce changes in the subcellular localization in subunit p47phox in dorsomedial nucleus tractus solitarius neurons. Systemic hypertension may produce alterations in the trafficking of proteins associated with superoxide production in central autonomic neurons. Administration of angiotensin over 7 days, which produces elevated systemic blood pressure, is associated with a redistribution of p47phox immunolabeling away from intracellular organelles in the distal dendritic compartment, and toward non-vesicular targets in less distal, intermediate areas of dorsomedial nucleus tractus solitarius neurons. Chronic administration of phenylephrine, which produces increases in systolic blood pressure, is associated with a repartitioning of p47phox immunolabeling away from intracellular organelles in distal dendritic areas, andtoward the plasma membrane of intermediate dendritic areas of dorsomedial nucleus tractus solitarius neurons Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum subunit p47phox, in dorsomedial nucleus tractus solitarius neurons of saline-treated animals. Administration of angiotensin over 7 days, which produces elevated systemic blood pressure, is associated with a redistribution of p47phox immunolabeling away from intracellular organelles in the distal dendritic compartment, and toward non-vesicular targets in less distal, intermediate areas of dorsomedial nucleus tractus solitarius neurons. Chronic administration of phenylephrine, which produces increases in systolic blood pressure, is associated with a repartitioning of p47phox immunolabeling away from intracellular organelles in distal dendritic areas, andtoward the plasma membrane of intermediate dendritic areas of dorsomedial nucleus tractus solitarius neurons Rattus norvegicus 5783
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plasmalemma synaptic and extrasynaptic areas of the plasmalemma, localization of subunit p47phox, in dorsomedial nucleus tractus solitarius neurons of saline-treated animals. Chronic administration of phenylephrine, which produces increases in systolic blood pressure, is associated with a repartitioning of p47phox immunolabeling away from intracellular organelles in distal dendritic areas, and toward the plasma membrane of intermediate dendritic areas of dorsomedial nucleus tractus solitarius neurons Rattus norvegicus
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
neuron dorsomedial nucleus tractus solitarius neuron. In small dendritic processes, both angiotensin II and phenylephrine produce a decrease in intracellular subunit p47phox labeling selectively in dorsomedial nucleus tractus solitarius neurons. In intermediate-size dendritic profiles in the dorsomedial nucleus tractus solitarius region only, there is an increase in p47phox labeling in response to each hypertensive agent, although these changes occurre in different subcellular compartments. There is an increase in non-vesicular labeling in response to angiotensin II, but an increase in surface labeling with phenylephrine Rattus norvegicus
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