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Literature summary for 1.6.3.1 extracted from

  • Matsushima, S.; Kinugawa, S.; Yokota, T.; Inoue, N.; Ohta, Y.; Hamaguchi, S.; Tsutsui, H.
    Increased myocardial NAD(P)H oxidase-derived superoxide causes the exacerbation of postinfarct heart failure in type 2 diabetes (2009), Am. J. Physiol. Heart Circ. Physiol., 297, H409-H416.
    View publication on PubMed
Search for more literature for 1.6.3.1

Inhibitors

Inhibitors Comment Organism Structure
apocynin inhibitor of NAD(P)H oxidase activation Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Mus musculus 16020
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
myocardium
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADPH + H+ + O2
-
 Mus musculus NADP+ + H2O2
-
 ?

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Mus musculus
heme
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus NAD(P)H oxidase activity is not increased in mice from the normal diet plus myocardial infarction group additional information
Mus musculus NAD(P)H oxidase activity is increased in noninfarcted left ventricular tissues from mice in the high fat diet plus myocardial infarction group up

General Information

General Information Comment Organism
physiological function increased myocardial NAD(P)H oxidase-derived superoxide causes the exacerbation of postinfarct heart failure in type 2 diabetes Mus musculus