Reference on EC 1.6.3.1 - NAD(P)H oxidase (H2O2-forming)
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Matsushita, K.; Otofuji, A.; Iwahashi, M.; Toyama, H.; Adachi, O.
NADH dehydrogenase of Corynebacterium glutamicum. Purification of an NADH dehydrogenase II homolog able to oxidize NADPH
FEMS Microbiol. Lett.
204
271-276
2001
Corynebacterium glutamicum
Capuozzo, E.; Crifo, C.; Salerno, C.
Polyene antibiotics inhibit superoxide-producing NADPH oxidase in a polymorphonuclear cell-free system
Biochem. Pharmacol.
45
766-768
1993
Bos taurus
Umeki, S.
Prostaglandin E1 and analogs of prostacyclin influencing superoxide production by the human neutrophil NADPH oxidase system
Int. J. Biochem.
26
1003-1008
1994
Homo sapiens
Umeki, S.
Mechanisms for the activation/electron transfer of neutrophil NADPH-oxidase complex and molecular pathology of chronic granulomatous disease
Ann. Hematol.
68
267-277
1994
Bos taurus, Cavia porcellus, Homo sapiens, Sus scrofa
Moreno, J.C.; Bikker, H.; Kempers, M.J.; van Trotsenburg, A.S.; Baas, F.; de Vijlder, J.J.; Vulsma, T.; Ris-Stalpers, C.
Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism
N. Engl. J. Med.
347
95-102
2002
Homo sapiens (Q9NRD8), Homo sapiens
De Deken, X.; Wang, D.; Dumont, J.E.; Miot, F.
Characterization of ThOX proteins as components of the thyroid H2O2-generating system
Exp. Cell Res.
273
187-196
2002
Canis lupus familiaris, Homo sapiens, Rattus norvegicus
De Deken, X.; Wang, D.; Many, M.C.; Costagliola, S.; Libert, F.; Vassart, G.; Dumont, J.E.; Miot, F.
Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family
J. Biol. Chem.
275
23227-23233
2000
Canis lupus familiaris, Sus scrofa, Caenorhabditis elegans (O61213), Caenorhabditis elegans, Homo sapiens (Q9NRD8), Homo sapiens
Dupuy, C.; Ohayon, R.; Valent, A.; Noel-Hudson, M.S.; Deme, D.; Virion, A.
Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cDNAs
J. Biol. Chem.
274
37265-37269
1999
Caenorhabditis elegans (O61213), Sus scrofa (Q8HZK2), Sus scrofa, Homo sapiens (Q9NRD8), Homo sapiens
Leseney, A.M.; Deme, D.; Legue, O.; Ohayon, R.; Chanson, P.; Sales, J.P.; Pires de Carvalho, D.; Dupuy, C.; Virion, A.
Biochemical characterization of a Ca2+/NAD(P)H-dependent H2O2 generator in human thyroid tissue
Biochimie
81
373-380
1999
Homo sapiens, Sus scrofa
Dupuy, C.; Virion, A.; Ohayon, R.; Kaniewski, J.; Deme, D.; Pommier, J.
Mechanism of hydrogen peroxide formation catalyzed by NADPH oxidase in thyroid plasma membrane
J. Biol. Chem.
266
3739-3743
1991
Sus scrofa
Dupuy, C.; Virion, A.; Hammou, N.A.; Kaniewski, J.; Deme, D.; Pommier, J.
Solubilization and characteristics of the thyroid NADPH-dependent hydrogen peroxide generating system
Biochem. Biophys. Res. Commun.
141
839-846
1986
Sus scrofa
Nakamura, Y.; Ogihara, S.; Ohtaki, S.
Activation by ATP of calcium-dependent NADPH-oxidase generating hydrogen peroxide in thyroid plasma membranes
J. Biochem.
102
1121-1132
1987
Sus scrofa
Ohayon, R.; Boeynaems, J.M.; Braekman, J.C.; Van den Bergen, H.; Gorin, Y.; Virion, A.
Inhibition of thyroid NADPH-oxidase by 2-iodohexadecanal in a cell-free system
Mol. Cell. Endocrinol.
99
133-141
1994
Sus scrofa
Carvalho, D.P.; Dupuy, C.; Gorin, Y.; Legue, O.; Pommier, J.; Haye, B.; Virion, A.
The Ca2+- and reduced nicotinamide adenine dinucleotide phosphate-dependent hydrogen peroxide generating system is induced by thyrotropin in porcine thyroid cells
Endocrinology
137
1007-1012
1996
Sus scrofa
Gorin, Y.; Leseney, A.M.; Ohayon, R.; Dupuy, C.; Pommier, J.; Virion, A.; Deme, D.
Regulation of the thyroid NADPH-dependent H2O2 generator by Ca2+: studies with phenylarsine oxide in thyroid plasma membrane
Biochem. J.
321
383-388
1997
Sus scrofa
-
Caillou, B.; Dupuy, C.; Lacroix, L.; Nocera, M.; Talbot, M.; Ohayon, R.; Deme, D.; Bidart, J.M.; Schlumberger, M.; Virion, A.
Expression of reduced nicotinamide adenine dinucleotide phosphate oxidase (ThoX, LNOX, Duox) genes and proteins in human thyroid tissues
J. Clin. Endocrinol. Metab.
86
3351-3358
2001
Homo sapiens (Q9NRD8)
Ferreira, A.C.F.; Cardoso, L.d.C.; Rosenthal, D.; Pires de Carvalho, D.
Thyroid Ca2+/NADPH-dependent H2O2 generation is partially inhibited by propylthiouracil and methimazole
Eur. J. Biochem.
270
2363-2368
2003
Homo sapiens
Fu, H.; Bylund, J.; Karlsson, A.; Pellme, S.; Dahlgren, C.
The mechanism for activation of the neutrophil NADPH-oxidase by the peptides formyl-Met-Leu-Phe and Trp-Lys-Tyr-Met-Val-Met differs from that for interleukin-8
Immunology
112
201-210
2004
Homo sapiens
Banfi, B.; Clark, R.A.; Steger, K.; Krause, K.H.
Two novel proteins activate superoxide generation by the NADPH oxidase NOX1
J. Biol. Chem.
278
3510-3513
2003
Mus musculus (Q8CIZ9)
Banfi, B.; Tirone, F.; Durussel, I.; Knisz, J.; Moskwa, P.; Molnar, G.Z.; Krause, K.H.; Cox, J.A.
Mechanism of Ca2+ activation of the NADPH oxidase 5 (NOX5)
J. Biol. Chem.
279
18583-18591
2004
Homo sapiens
Banfi, B.; Malgrange, B.; Knisz, J.; Steger, K.; Dubois-Dauphin, M.; Krause, K.H.
NOX3, a superoxide-generating NADPH oxidase of the inner ear
J. Biol. Chem.
279
46065-46072
2004
Mus musculus (Q672J9), Rattus norvegicus (Q672K1)
Mizrahi, A.; Molshanski-Mor, S.; Weinbaum, C.; Zheng, Y.; Hirshberg, M.; Pick, E.
Activation of the phagocyte NADPH oxidase by Rac guanine nucleotide exchange factors in conjunction with ATP and nucleoside diphosphate kinase
J. Biol. Chem.
280
3802-3811
2005
Cavia porcellus
Park, H.S.; Jung, H.Y.; Park, E.Y.; Kim, J.; Lee, W.J.; Bae, Y.S.
Direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kB
J. Immunol.
173
3589-3593
2004
Homo sapiens
Ambruso, D.R.; Cusack, N.; Thurman, G.
NADPH oxidase activity of neutrophil specific granules: requirements for cytosolic components and evidence of assembly during cell activation
Mol. Genet. Metab.
81
313-321
2004
Homo sapiens
El Hassani, R.A.; Benfares, N.; Caillou, B.; Talbot, M.; Sabourin, J.; Belotte, V.; Morand, S.; Gnidehou, S.; Agnandji, D.; Ohayon, R.; Kaniewski, J.; Noel-Hudson, M.; Bidart, J.; Schlumberger, M.; Virion, A.; Dupuy, C.
Dual oxidase2 is expressed all along the digestive tract
Am. J. Physiol.
288
G933-G942
2005
Homo sapiens, Sus scrofa
Cheranov, S.Y.; Jaggar, J.H.
TNF-alpha dilates cerebral arteries via NAD(P)H oxidase-dependent Ca2+ spark activation
Am. J. Physiol.
290
C964-C971
2006
Rattus norvegicus
Biswas, S.; Gupta, M.K.; Chattopadhyay, D.; Mukhopadhyay, C.K.
Insulin-induced activation of hypoxia inducible factor-1 requires generation of reactive oxygen species by NADPH oxidase
Am. J. Physiol. Heart Circ. Physiol.
292
758-766
2006
Homo sapiens
Park, H.S.; Park, D.; Bae, Y.S.
Molecular interaction of NADPH oxidase 1 with betaPix and Nox Organizer 1
Biochem. Biophys. Res. Commun.
339
985-990
2006
Homo sapiens
Petheo, G.L.; Demaurex, N.
Voltage- and NADPH-dependence of electron currents generated by the phagocytic NADPH oxidase
Biochem. J.
388
485-491
2005
Homo sapiens
Lountos, G.T.; Jiang, R.; Wellborn, W.B.; Thaler, T.L.; Bommarius, A.S.; Orville, A.M.
The crystal structure of NAD(P)H oxidase from Lactobacillus sanfranciscensis: insights into the conversion of O2 into two water molecules by the flavoenzyme
Biochemistry
45
9648-9659
2006
Fructilactobacillus sanfranciscensis, Lactococcus lactis
Liu, Q.; Kang, J.; Zheng, R.
NADPH oxidase produces reactive oxygen species and maintains survival of rat astrocytes
Cell Biochem. Funct.
23
93-100
2005
Rattus norvegicus
Hiruta, J.; Mazet, F.; Ogasawara, M.
Restricted expression of NADPH oxidase/peroxidase gene (Duox) in zone VII of the ascidian endostyle
Cell Tissue Res.
326
835-841
2006
Ciona intestinalis
Miller, A.A.; Drummond, G.R.; Schmidt, H.H.; Sobey, C.G.
NADPH oxidase activity and function are profoundly greater in cerebral versus systemic arteries
Circ. Res.
97
1055-1062
2005
Rattus norvegicus
Pfarr, N.; Korsch, E.; Kaspers, S.; Herbst, A.; Stach, A.; Zimmer, C.; Pohlenz, J.
Congenital hypothyroidism caused by new mutations in the thyroid oxidase 2 (THOX2) gene
Clin. Endocrinol. (Oxf.)
65
810-815
2006
Homo sapiens
Carnesecchi, S.; Carpentier, J.L.; Foti, M.; Szanto, I.
Insulin-induced vascular endothelial growth factor expression is mediated by the NADPH oxidase NOX3
Exp. Cell Res.
312
3413-3424
2006
Homo sapiens
Harper, R.W.; Xu, C.; Eiserich, J.P.; Chen, Y.; Kao, C.Y.; Thai, P.; Setiadi, H.; Wu, R.
Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium
FEBS Lett.
579
4911-4917
2005
Homo sapiens
Djordjevic, T.; Pogrebniak, A.; BelAiba, R.S.; Bonello, S.; Wotzlaw, C.; Acker, H.; Hess, J.; Goerlach, A.
The expression of the NADPH oxidase subunit p22phox is regulated by a redox-sensitive pathway in endothelial cells
Free Radic. Biol. Med.
38
616-630
2005
Homo sapiens
Maia, L.; Vala, A.; Mira, L.
NADH oxidase activity of rat liver xanthine dehydrogenase and xanthine oxidase-contribution for damage mechanisms
Free Radic. Res.
39
979-986
2005
Rattus norvegicus
Li, X.J.; Grunwald, D.; Mathieu, J.; Morel, F.; Stasia, M.J.
Crucial role of two potential cytosolic regions of Nox2, 191TSSTKTIRRS200 and 484DESQANHFAVHHDEEKD500, on NADPH oxidase activation
J. Biol. Chem.
280
14962-14973
2005
Homo sapiens
Ameziane-El-Hassani, R.; Morand, S.; Boucher, J.L.; Frapart, Y.M.; Apostolou, D.; Agnandji, D.; Gnidehou, S.; Ohayon, R.; Noel-Hudson, M.S.; Francon, J.; Lalaoui, K.; Virion, A.; Dupuy, C.
Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity
J. Biol. Chem.
280
30046-30054
2005
Homo sapiens, Sus scrofa
Grasberger, H.; Refetoff, S.
Identification of the maturation factor for dual oxidase. Evolution of an eukaryotic operon equivalent
J. Biol. Chem.
281
18269-18272
2006
Homo sapiens
Hidalgo, C.; Sanchez, G.; Barrientos, G.; Aracena-Parks, P.
A transverse tubule NADPH oxidase activity stimulates calcium release from isolated triads via ryanodine receptor type 1 S -glutathionylation
J. Biol. Chem.
281
26473-26482
2006
Mus musculus
Jekabsone, A.; Mander, P.K.; Tickler, A.; Sharpe, M.; Brown, G.C.
Fibrillar beta-amyloid peptide Abeta1-40 activates microglial proliferation via stimulating TNF-alpha release and H2O2 derived from NADPH oxidase: a cell culture study
J. Neuroinflammation
3
24
2006
Rattus norvegicus
Hao, F.; Wang, X.; Chen, J.
Involvement of plasma-membrane NADPH oxidase in nickel-induced oxidative stress in roots of wheat seedlings
Plant Sci.
170
151-158
2006
Triticum turgidum subsp. durum
Hritz, J.; Zoldak, G.; Sedlak, E.
Cofactor assisted gating mechanism in the active site of NADH oxidase from Thermus thermophilus
Proteins
64
465-476
2006
Thermus thermophilus
Wong, K.L.; Wu, K.C.; Wu, R.S.; Chou, Y.H.; Cheng, T.H.; Hong, H.J.
Tetramethylpyrazine inhibits angiotensin II-increased NAD(P)H oxidase activity and subsequent proliferation in rat aortic smooth muscle cells
Am. J. Chin. Med.
35
1021-1035
2007
Rattus norvegicus
Marcal, L.E.; Dias-da-Motta, P.M.; Rehder, J.; Mamoni, R.L.; Blotta, M.H.; Whitney, C.B.; Newburger, P.E.; Costa, F.F.; Saad, S.T.; Condino-Neto, A.
Up-regulation of NADPH oxidase components and increased production of interferon-gamma by leukocytes from sickle cell disease patients
Am. J. Hematol.
83
41-45
2008
Homo sapiens
Whaley-Connell, A.T.; Morris, E.M.; Rehmer, N.; Yaghoubian, J.C.; Wei, Y.; Hayden, M.R.; Habibi, J.; Stump, C.S.; Sowers, J.R.
Albumin activation of NAD(P)H oxidase activity is mediated via Rac1 in proximal tubule cells
Am. J. Nephrol.
27
15-23
2007
Didelphis sp.
Chandramohan, G.; Bai, Y.; Norris, K.; Rodriguez-Iturbe, B.; Vaziri, N.D.
Effects of dietary salt on intrarenal angiotensin system, NAD(P)H oxidase, COX-2, MCP-1 and PAI-1 expressions and NF-kappaB activity in salt-sensitive and -resistant rat kidneys
Am. J. Nephrol.
28
158-167
2008
Rattus norvegicus
Benter, I.F.; Yousif, M.H.; Dhaunsi, G.S.; Kaur, J.; Chappell, M.C.; Diz, D.I.
Angiotensin-(1-7) prevents activation of NADPH oxidase and renal vascular dysfunction in diabetic hypertensive rats
Am. J. Nephrol.
28
25-33
2008
Rattus norvegicus
Orosz, Z.; Csiszar, A.; Labinskyy, N.; Smith, K.; Kaminski, P.M.; Ferdinandy, P.; Wolin, M.S.; Rivera, A.; Ungvari, Z.
Cigarette smoke-induced proinflammatory alterations in the endothelial phenotype: role of NAD(P)H oxidase activation
Am. J. Physiol. Heart Circ. Physiol.
292
H130-H139
2007
Rattus norvegicus
Chen, J.X.; Zeng, H.; Tuo, Q.H.; Yu, H.; Meyrick, B.; Aschner, J.L.
NADPH oxidase modulates myocardial Akt, ERK1/2 activation, and angiogenesis after hypoxia-reoxygenation
Am. J. Physiol. Heart Circ. Physiol.
292
H1664-H1674
2007
Mus musculus, Sus scrofa
Fukatsu, A.; Hayashi, T.; Miyazaki-Akita, A.; Matsui-Hirai, H.; Furutate, Y.; Ishitsuka, A.; Hattori, Y.; Iguchi, A.
Possible usefulness of apocynin, an NADPH oxidase inhibitor, for nitrate tolerance: prevention of NO donor-induced endothelial cell abnormalities
Am. J. Physiol. Heart Circ. Physiol.
293
H790-H797
2007
Bos taurus
Wolfort, R.M.; Stokes, K.Y.; Granger, D.N.
CD4+ T lymphocytes mediate hypercholesterolemia-induced endothelial dysfunction via a NAD(P)H oxidase-dependent mechanism
Am. J. Physiol. Heart Circ. Physiol.
294
H2619-H2626
2008
Mus musculus
Abdala-Valencia, H.; Earwood, J.; Bansal, S.; Jansen, M.; Babcock, G.; Garvy, B.; Wills-Karp, M.; Cook-Mills, J.M.
Nonhematopoietic NADPH oxidase regulation of lung eosinophilia and airway hyperresponsiveness in experimentally induced asthma
Am. J. Physiol. Lung Cell. Mol. Physiol.
292
L1111-L1125
2007
Mus musculus
Chitano, P.; Wang, L.; Mason, S.N.; Auten, R.L.; Potts, E.N.; Foster, W.M.; Sturrock, A.; Kennedy, T.P.; Hoidal, J.R.; Murphy, T.M.
Airway smooth muscle relaxation is impaired in mice lacking the p47phox subunit of NAD(P)H oxidase
Am. J. Physiol. Lung Cell. Mol. Physiol.
294
L139-L148
2008
Mus musculus
Chen, P.; Guo, A.M.; Edwards, P.A.; Trick, G.; Scicli, A.G.
Role of NADPH oxidase and ANG II in diabetes-induced retinal leukostasis
Am. J. Physiol. Regul. Integr. Comp. Physiol.
293
R1619-R1629
2007
Rattus norvegicus
Liu, R.; Garvin, J.L.; Ren, Y.; Pagano, P.J.; Carretero, O.A.
Depolarization of the macula densa induces superoxide production via NAD(P)H oxidase
Am. J. Physiol. Renal Physiol.
292
F1867-F1872
2007
Oryctolagus cuniculus
Turchan-Cholewo, J.; Dimayuga, V.M.; Gupta, S.; Gorospe, R.M.; Keller, J.; Bruce-Keller, A.J.
NADPH oxidase drives cytokine and neurotoxin release from microglia and macrophages in response to HIV-Tat
Antioxid. Redox Signal.
11
193-204
2008
Mus musculus
Steffen, Y.; Gruber, C.; Schewe, T.; Sies, H.
Mono-O-methylated flavanols and other flavonoids as inhibitors of endothelial NADPH oxidase
Arch. Biochem. Biophys.
469
209-219
2008
Homo sapiens
Choi, S.I.; Jeong, C.S.; Cho, S.Y.; Lee, Y.S.
Mechanism of apoptosis induced by apigenin in HepG2 human hepatoma cells: involvement of reactive oxygen species generated by NADPH oxidase
Arch. Pharm. Res.
30
1328-1335
2007
Homo sapiens
Datla, S.R.; Peshavariya, H.; Dusting, G.J.; Mahadev, K.; Goldstein, B.J.; Jiang, F.
Important role of Nox4 type NADPH oxidase in angiogenic responses in human microvascular endothelial cells in vitro
Arterioscler. Thromb. Vasc. Biol.
27
2319-2324
2007
Homo sapiens
Ceolotto, G.; Gallo, A.; Papparella, I.; Franco, L.; Murphy, E.; Iori, E.; Pagnin, E.; Fadini, G.P.; Albiero, M.; Semplicini, A.; Avogaro, A.
Rosiglitazone reduces glucose-induced oxidative stress mediated by NAD(P)H oxidase via AMPK-dependent mechanism
Arterioscler. Thromb. Vasc. Biol.
27
2627-2633
2007
Homo sapiens
Ostanin, D.V.; Barlow, S.; Shukla, D.; Grisham, M.B.
NADPH oxidase but not myeloperoxidase protects lymphopenic mice from spontaneous infections
Biochem. Biophys. Res. Commun.
355
801-806
2007
Mus musculus
Steffen, Y.; Schewe, T.; Sies, H.
(-)-Epicatechin elevates nitric oxide in endothelial cells via inhibition of NADPH oxidase
Biochem. Biophys. Res. Commun.
359
828-833
2007
Homo sapiens
Verchier, Y.; Lardy, B.; Nguyen, M.V.; Morel, F.; Arbault, S.; Amatore, C.
Concerted activities of nitric oxide synthases and NADPH oxidases in PLB-985 cells
Biochem. Biophys. Res. Commun.
361
493-498
2007
Homo sapiens
Nishikawa, H.; Wakano, K.; Kitani, S.
Inhibition of NADPH oxidase subunits translocation by tea catechin EGCG in mast cell
Biochem. Biophys. Res. Commun.
362
504-509
2007
Canis lupus familiaris, Homo sapiens
Ahluwalia, J.
Characterisation of electron currents generated by the human neutrophil NADPH oxidase
Biochem. Biophys. Res. Commun.
368
656-661
2008
Homo sapiens
Pacquelet, S.; Johnson, J.L.; Ellis, B.A.; Brzezinska, A.A.; Lane, W.S.; Munafo, D.B.; Catz, S.D.
Cross-talk between IRAK-4 and the NADPH oxidase
Biochem. J.
403
451-461
2007
Homo sapiens
Murillo, M.M.; Carmona-Cuenca, I.; Del Castillo, G.; Ortiz, C.; Roncero, C.; Sanchez, A.; Fernandez, M.; Fabregat, I.
Activation of NADPH oxidase by transforming growth factor-beta in hepatocytes mediates up-regulation of epidermal growth factor receptor ligands through a nuclear factor-kappaB-dependent mechanism
Biochem. J.
405
251-259
2007
Rattus norvegicus
Nisimoto, Y.; Tsubouchi, R.; Diebold, B.A.; Qiao, S.; Ogawa, H.; Ohara, T.; Tamura, M.
Activation of NADPH oxidase 1 in tumor colon epithelial cell
Biochem. J.
415
57-65
2008
Homo sapiens
Shen, K.; Sergeant, S.; Hantgan, R.R.; McPhail, L.C.; Horita, D.A.
Mutations in the PX-SH3A linker of p47phox decouple PI(3,4)P2 binding from NADPH oxidase activation
Biochemistry
47
8855-8865
2008
Homo sapiens
Catarzi, S.; Giannoni, E.; Favilli, F.; Meacci, E.; Iantomasi, T.; Vincenzini, M.T.
Sphingosine 1-phosphate stimulation of NADPH oxidase activity: relationship with platelet-derived growth factor receptor and c-Src kinase
Biochim. Biophys. Acta
1770
872-883
2007
Mus musculus
Mouche, S.; Mkaddem, S.B.; Wang, W.; Katic, M.; Tseng, Y.H.; Carnesecchi, S.; Steger, K.; Foti, M.; Meier, C.A.; Muzzin, P.; Kahn, C.R.; Ogier-Denis, E.; Szanto, I.
Reduced expression of the NADPH oxidase NOX4 is a hallmark of adipocyte differentiation
Biochim. Biophys. Acta
1773
1015-1027
2007
Mus musculus
Inoue, T.; Suzuki, Y.; Yoshimaru, T.; Ra, C.
Reactive oxygen species produced up- or downstream of calcium influx regulate proinflammatory mediator release from mast cells: role of NADPH oxidase and mitochondria
Biochim. Biophys. Acta
1783
789-802
2008
Mus musculus
Miyano, K.; Sumimoto, H.
Role of the small GTPase Rac in p22phox-dependent NADPH oxidases
Biochimie
89
1133-1144
2007
Homo sapiens
Tian, W.; Li, X.J.; Stull, N.D.; Ming, W.; Suh, C.I.; Bissonnette, S.A.; Yaffe, M.B.; Grinstein, S.; Atkinson, S.J.; Dinauer, M.C.
Fc{gamma}R-stimulated activation of the NADPH oxidase: Phosphoinositide binding protein p40phox regulates NADPH oxidase activity after enzyme assembly on the phagosome
Blood
112
3867-3877
2008
Homo sapiens
Sicard, P.; Acar, N.; Gregoire, S.; Lauzier, B.; Bron, A.M.; Creuzot-Garcher, C.; Bretillon, L.; Vergely, C.; Rochette, L.
Influence of rosuvastatin on the NAD(P)H oxidase activity in the retina and electroretinographic response of spontaneously hypertensive rats
Br. J. Pharmacol.
151
979-986
2007
Rattus norvegicus
Campese, V.M.; Sindhu, R.K.; Ye, S.; Bai, Y.; Vaziri, N.D.; Jabbari, B.
Regional expression of NO synthase, NAD(P)H oxidase and superoxide dismutase in the rat brain
Brain Res.
1134
27-32
2007
Rattus norvegicus
Miller, R.L.; Sun, G.Y.; Sun, A.Y.
Cytotoxicity of paraquat in microglial cells: Involvement of PKCdelta- and ERK1/2-dependent NADPH oxidase
Brain Res.
1167
129-139
2007
Mus musculus
Li, B.; Guo, Y.S.; Sun, M.M.; Dong, H.; Wu, S.Y.; Wu, D.X.; Li, C.Y.
The NADPH oxidase is involved in lipopolysaccharide-mediated motor neuron injury
Brain Res.
1226
199-208
2008
Rattus norvegicus
Zhao, W.; Zhao, D.; Yan, R.; Sun, Y.
Cardiac oxidative stress and remodeling following infarction: role of NADPH oxidase
Cardiovasc. Pathol.
18
156-166
2008
Mus musculus
An, S.J.; Boyd, R.; Zhu, M.; Chapman, A.; Pimentel, D.R.; Wang, H.D.
NADPH oxidase mediates angiotensin II-induced endothelin-1 expression in vascular adventitial fibroblasts
Cardiovasc. Res.
75
702-709
2007
Mus musculus
Chan, E.C.; Datla, S.R.; Dilley, R.; Hickey, H.; Drummond, G.R.; Dusting, G.J.
Adventitial application of the NADPH oxidase inhibitor apocynin in vivo reduces neointima formation and endothelial dysfunction in rabbits
Cardiovasc. Res.
75
710-718
2007
Oryctolagus cuniculus
Sanchez, G.; Escobar, M.; Pedrozo, Z.; Macho, P.; Domenech, R.; Haertel, S.; Hidalgo, C.; Donoso, P.
Exercise and tachycardia increase NADPH oxidase and ryanodine receptor-2 activity: possible role in cardioprotection
Cardiovasc. Res.
77
380-386
2008
Canis lupus familiaris
Ren, Z.; Raucci, F.J.; Browe, D.M.; Baumgarten, C.M.
Regulation of swelling-activated Cl- current by angiotensin II signalling and NADPH oxidase in rabbit ventricle
Cardiovasc. Res.
77
73-80
2008
Oryctolagus cuniculus
Schlueter, T.; Steinbach, A.C.; Steffen, A.; Rettig, R.; Grisk, O.
Apocynin-induced vasodilation involves Rho kinase inhibition but not NADPH oxidase inhibition
Cardiovasc. Res.
80
271-279
2008
Mus musculus, Rattus norvegicus
Owayed, A.; Dhaunsi, G.S.; Al-Mukhaizeem, F.
Nitric oxide-mediated activation of NADPH oxidase by salbutamol during acute asthma in children
Cell Biochem. Funct.
26
603-608
2008
Homo sapiens
Brechard, S.; Melchior, C.; Plancon, S.; Schenten, V.; Tschirhart, E.J.
Store-operated Ca(2+) channels formed by TRPC1, TRPC6 and Orai1 and non-store-operated channels formed by TRPC3 are involved in the regulation of NADPH oxidase in HL-60 granulocytes
Cell Calcium
44
492-506
2008
Homo sapiens
Becker, S.; Reinehr, R.; Graf, D.; vom Dahl, S.; Haeussinger, D.
Hydrophobic bile salts induce hepatocyte shrinkage via NADPH oxidase activation
Cell. Physiol. Biochem.
19
89-98
2007
Mus musculus
Zhang, F.; Jin, S.; Yi, F.; Xia, M.; Dewey, W.L.; Li, P.L.
Local production of O2- by NAD(P)H oxidase in the sarcoplasmic reticulum of coronary arterial myocytes: cADPR-mediated Ca2+ regulation
Cell. Signal.
20
637-644
2008
Bos taurus
Doerries, C.; Grote, K.; Hilfiker-Kleiner, D.; Luchtefeld, M.; Schaefer, A.; Holland, S.M.; Sorrentino, S.; Manes, C.; Schieffer, B.; Drexler, H.; Landmesser, U.
Critical role of the NAD(P)H oxidase subunit p47phox for left ventricular remodeling/dysfunction and survival after myocardial infarction
Circ. Res.
100
894-903
2007
Mus musculus
Mittal, M.; Roth, M.; Koenig, P.; Hofmann, S.; Dony, E.; Goyal, P.; Selbitz, A.C.; Schermuly, R.T.; Ghofrani, H.A.; Kwapiszewska, G.; Kummer, W.; Klepetko, W.; Hoda, M.A.; Fink, L.; Haenze, J.; Seeger, W.; Grimminger, F.; Schmidt, H.H.; Weissmann, N.
Hypoxia-dependent regulation of nonphagocytic NADPH oxidase subunit NOX4 in the pulmonary vasculature
Circ. Res.
101
258-267
2007
Homo sapiens, Mus musculus
Silver, A.E.; Beske, S.D.; Christou, D.D.; Donato, A.J.; Moreau, K.L.; Eskurza, I.; Gates, P.E.; Seals, D.R.
Overweight and obese humans demonstrate increased vascular endothelial NAD(P)H oxidase-p47(phox) expression and evidence of endothelial oxidative stress
Circulation
115
627-637
2007
Homo sapiens
Thallas-Bonke, V.; Thorpe, S.R.; Coughlan, M.T.; Fukami, K.; Yap, F.Y.; Sourris, K.C.; Penfold, S.A.; Bach, L.A.; Cooper, M.E.; Forbes, J.M.
Inhibition of NADPH oxidase prevents advanced glycation end product-mediated damage in diabetic nephropathy through a protein kinase C-alpha-dependent pathway
Diabetes
57
460-469
2008
Rattus norvegicus
Dammanahalli, J.K.; Sun, Z.
Endothelin-1 inhibits NADPH oxidase activity in human abdominal aortic endothelial cells: A novel function of ETB1 receptors
Endocrinology
149
4979-4987
2008
Homo sapiens
Cano-Dominguez, N.; Alvarez-Delfin, K.; Hansberg, W.; Aguirre, J.
NADPH oxidases NOX-1 and NOX-2 require the regulatory subunit NOR-1 to control cell differentiation and growth in Neurospora crassa
Eukaryot. Cell
7
1352-1361
2008
Neurospora crassa
Donini, M.; Zenaro, E.; Tamassia, N.; Dusi, S.
NADPH oxidase of human dendritic cells: role in Candida albicans killing and regulation by interferons, dectin-1 and CD206
Eur. J. Immunol.
37
1194-1203
2007
Homo sapiens
Ding, H.; Hashem, M.; Triggle, C.
Increased oxidative stress in the streptozotocin-induced diabetic apoE-deficient mouse: changes in expression of NADPH oxidase subunits and eNOS
Eur. J. Pharmacol.
561
121-128
2007
Mus musculus
Borges de Oliveira-Junior, E.; Thomazzi, S.M.; Rehder, J.; Antunes, E.; Condino-Neto, A.
Effects of BAY 41-2272, an activator of nitric oxide-independent site of soluble guanylate cyclase, on human NADPH oxidase system from THP-1 cells
Eur. J. Pharmacol.
567
43-49
2007
Homo sapiens
Matthiesen, S.; Lindemann, D.; Warnken, M.; Juergens, U.R.; Racke, K.
Inhibition of NADPH oxidase by apocynin inhibits lipopolysaccharide (LPS) induced up-regulation of arginase in rat alveolar macrophages
Eur. J. Pharmacol.
579
403-410
2008
Rattus norvegicus
Glass, M.J.; Chan, J.; Frys, K.A.; Oselkin, M.; Tarsitano, M.J.; Iadecola, C.; Pickel, V.M.
Changes in the subcellular distribution of NADPH oxidase subunit p47phox in dendrites of rat dorsomedial nucleus tractus solitarius neurons in response to chronic administration of hypertensive agents
Exp. Neurol.
205
383-395
2007
Rattus norvegicus
Siragy, H.M.; Huang, J.
Renal (pro)renin receptor upregulation in diabetic rats through enhanced angiotensin AT1 receptor and NADPH oxidase activity
Exp. Physiol.
93
709-714
2008
Rattus norvegicus
Chen, C.Y.; Liu, T.Z.; Chen, C.H.; Wu, C.C.; Cheng, J.T.; Yiin, S.J.; Shih, M.K.; Wu, M.J.; Chern, C.L.
Isoobtusilactone A-induced apoptosis in human hepatoma Hep G2 cells is mediated via increased NADPH oxidase-derived reactive oxygen species (ROS) production and the mitochondria-associated apoptotic mechanisms
Food Chem. Toxicol.
45
1268-1276
2007
Homo sapiens, Rattus norvegicus
Sheh, Y.L.; Hsu, C.; Chan, S.H.; Chan, J.Y.
NADPH oxidase- and mitochondrion-derived superoxide at rostral ventrolateral medulla in endotoxin-induced cardiovascular depression
Free Radic. Biol. Med.
42
1610-1623
2007
Rattus norvegicus
Deng, S.; Kruger, A.; Kleschyov, A.L.; Kalinowski, L.; Daiber, A.; Wojnowski, L.
Gp91phox-containing NAD(P)H oxidase increases superoxide formation by doxorubicin and NADPH
Free Radic. Biol. Med.
42
466-473
2007
Mus musculus
Liu, S.; Ma, X.; Gong, M.; Shi, L.; Lincoln, T.; Wang, S.
Glucose down-regulation of cGMP-dependent protein kinase I expression in vascular smooth muscle cells involves NAD(P)H oxidase-derived reactive oxygen species
Free Radic. Biol. Med.
42
852-863
2007
Rattus norvegicus
Stokes, K.Y.; Russell, J.M.; Jennings, M.H.; Alexander, J.S.; Granger, D.N.
Platelet-associated NAD(P)H oxidase contributes to the thrombogenic phenotype induced by hypercholesterolemia
Free Radic. Biol. Med.
43
22-30
2007
Mus musculus
Qin, F.; Simeone, M.; Patel, R.
Inhibition of NADPH oxidase reduces myocardial oxidative stress and apoptosis and improves cardiac function in heart failure after myocardial infarction
Free Radic. Biol. Med.
43
271-281
2007
Oryctolagus cuniculus
Ribe, D.; Sawbridge, D.; Thakur, S.; Hussey, M.; Ledent, C.; Kitchen, I.; Hourani, S.; Li, J.M.
Adenosine A2A receptor signaling regulation of cardiac NADPH oxidase activity
Free Radic. Biol. Med.
44
1433-1442
2008
Mus musculus
Sheu, M.L.; Chiang, C.K.; Tsai, K.S.; Ho, F.M.; Weng, T.I.; Wu, H.Y.; Liu, S.H.
Inhibition of NADPH oxidase-related oxidative stress-triggered signaling by honokiol suppresses high glucose-induced human endothelial cell apoptosis
Free Radic. Biol. Med.
44
2043-2050
2008
Homo sapiens
Benavente, C.A.; Jacobson, E.L.
Niacin restriction upregulates NADPH oxidase and reactive oxygen species (ROS) in human keratinocytes
Free Radic. Biol. Med.
44
527-537
2008
Homo sapiens
Coyoy, A.; Valencia, A.; Guemez-Gamboa, A.; Moran, J.
Role of NADPH oxidase in the apoptotic death of cultured cerebellar granule neurons
Free Radic. Biol. Med.
45
1056-1064
2008
Rattus norvegicus
Riazi, S.; Madala-Halagappa, V.K.; Dantas, A.P.; Hu, X.; Ecelbarger, C.A.
Sex differences in renal nitric oxide synthase, NAD(P)H oxidase, and blood pressure in obese Zucker rats
Gend. Med.
4
214-229
2007
Rattus norvegicus
Wei, Y.; Whaley-Connell, A.T.; Chen, K.; Habibi, J.; Uptergrove, G.M.; Clark, S.E.; Stump, C.S.; Ferrario, C.M.; Sowers, J.R.
NADPH oxidase contributes to vascular inflammation, insulin resistance, and remodeling in the transgenic (mRen2) rat
Hypertension
50
384-391
2007
Rattus norvegicus
Datla, S.R.; Dusting, G.J.; Mori, T.A.; Taylor, C.J.; Croft, K.D.; Jiang, F.
Induction of heme oxygenase-1 in vivo suppresses NADPH oxidase derived oxidative stress
Hypertension
50
636-642
2007
Homo sapiens, Mus musculus, Rattus norvegicus
Cao, X.; Dai, X.; Parker, L.M.; Kreulen, D.L.
Differential regulation of NADPH oxidase in sympathetic and sensory ganglia in deoxycorticosterone acetate salt hypertension
Hypertension
50
663-671
2007
Rattus norvegicus
Jackson, E.K.; Gillespie, D.G.; Zhu, C.; Ren, J.; Zacharia, L.C.; Mi, Z.
Alpha2-adrenoceptors enhance angiotensin II-induced renal vasoconstriction: role for NADPH oxidase and RhoA
Hypertension
51
719-726
2008
Rattus norvegicus
Izakovicova Holla, L.; Kankova, K.; Znojil, V.
Haplotype analysis of the NADPH oxidase p22 gene in patients with bronchial asthma
Int. Arch. Allergy Immunol.
148
73-80
2008
Homo sapiens
Shono, T.; Yokoyama, N.; Uesaka, T.; Kuroda, J.; Takeya, R.; Yamasaki, T.; Amano, T.; Mizoguchi, M.; Suzuki, S.O.; Niiro, H.; Miyamoto, K.; Akashi, K.; Iwaki, T.; Sumimoto, H.; Sasaki, T.
Enhanced expression of NADPH oxidase Nox4 in human gliomas and its roles in cell proliferation and survival
Int. J. Cancer
123
787-792
2008
Homo sapiens
Babilonia, E.; Lin, D.; Zhang, Y.; Wei, Y.; Yue, P.; Wang, W.H.
Role of gp91phox -containing NADPH oxidase in mediating the effect of K restriction on ROMK channels and renal K excretion
J. Am. Soc. Nephrol.
18
2037-2045
2007
Mus musculus
Nakashima, T.; Iwashita, T.; Fujita, T.; Sato, E.; Niwano, Y.; Kohno, M.; Kuwahara, S.; Harada, N.; Takeshita, S.; Oda, T.
A prodigiosin analogue inactivates NADPH oxidase in macrophage cells by inhibiting assembly of p47phox and Rac
J. Biochem.
143
107-115
2008
Mus musculus
Si, J.; Fu, X.; Behar, J.; Wands, J.; Beer, D.G.; Souza, R.F.; Spechler, S.J.; Lambeth, D.; Cao, W.
NADPH oxidase NOX5-S mediates acid-induced cyclooxygenase-2 expression via activation of NF-kappaB in Barretts esophageal adenocarcinoma cells
J. Biol. Chem.
282
16244-16255
2007
Homo sapiens
Usatyuk, P.V.; Romer, L.H.; He, D.; Parinandi, N.L.; Kleinberg, M.E.; Zhan, S.; Jacobson, J.R.; Dudek, S.M.; Pendyala, S.; Garcia, J.G.; Natarajan, V.
Regulation of hyperoxia-induced NADPH oxidase activation in human lung endothelial cells by the actin cytoskeleton and cortactin
J. Biol. Chem.
282
23284-23295
2007
Homo sapiens
Chen, J.; He, R.; Minshall, R.D.; Dinauer, M.C.; Ye, R.D.
Characterization of a mutation in the Phox homology domain of the NADPH oxidase component p40phox identifies a mechanism for negative regulation of superoxide production
J. Biol. Chem.
282
30273-30284
2007
Homo sapiens
Abid, M.R.; Spokes, K.C.; Shih, S.C.; Aird, W.C.
NADPH oxidase activity selectively modulates vascular endothelial growth factor signaling pathways
J. Biol. Chem.
282
35373-35385
2007
Homo sapiens
Block, K.; Gorin, Y.; Hoover, P.; Williams, P.; Chelmicki, T.; Clark, R.A.; Yoneda, T.; Abboud, H.E.
NAD(P)H oxidases regulate HIF-2alpha protein expression
J. Biol. Chem.
282
8019-8026
2007
Homo sapiens, Mus musculus
Bissonnette, S.A.; Glazier, C.M.; Stewart, M.Q.; Brown, G.E.; Ellson, C.D.; Yaffe, M.B.
Phosphatidylinositol 3-phosphate-dependent and -independent functions of p40phox in activation of the neutrophil NADPH oxidase
J. Biol. Chem.
283
2108-2119
2008
Homo sapiens
Roepstorff, K.; Rasmussen, I.; Sawada, M.; Cudre-Maroux, C.; Salmon, P.; Bokoch, G.; van Deurs, B.; Vilhardt, F.
Stimulus-dependent regulation of the phagocyte NADPH oxidase by a VAV1, Rac1, and PAK1 signaling axis
J. Biol. Chem.
283
7983-7993
2008
Mus musculus
Ogasawara, Y.; Kaya, H.; Hiraoka, G.; Yumoto, F.; Kimura, S.; Kadota, Y.; Hishinuma, H.; Senzaki, E.; Yamagoe, S.; Nagata, K.; Nara, M.; Suzuki, K.; Tanokura, M.; Kuchitsu, K.
Synergistic activation of the Arabidopsis NADPH oxidase AtrbohD by Ca2+ and phosphorylation
J. Biol. Chem.
283
8885-8892
2008
Arabidopsis thaliana (Q9FIJ0), Arabidopsis thaliana
Ding, H.; Aljofan, M.; Triggle, C.R.
Oxidative stress and increased eNOS and NADPH oxidase expression in mouse microvessel endothelial cells
J. Cell. Physiol.
212
682-689
2007
Mus musculus
Wakisaka, Y.; Miller, J.D.; Chu, Y.; Baumbach, G.L.; Wilson, S.; Faraci, F.M.; Sigmund, C.D.; Heistad, D.D.
Oxidative stress through activation of NAD(P)H oxidase in hypertensive mice with spontaneous intracranial hemorrhage
J. Cereb. Blood Flow Metab.
28
1175-1185
2008
Mus musculus
Fan, J.; Li, Y.; Levy, R.M.; Fan, J.J.; Hackam, D.J.; Vodovotz, Y.; Yang, H.; Tracey, K.J.; Billiar, T.R.; Wilson, M.A.
Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1-TLR4 signaling
J. Immunol.
178
6573-6580
2007
Mus musculus
Benedyk, M.; Sopalla, C.; Nacken, W.; Bode, G.; Melkonyan, H.; Banfi, B.; Kerkhoff, C.
HaCaT keratinocytes overexpressing the S100 proteins S100A8 and S100A9 show increased NADPH oxidase and NF-kappaB activities
J. Invest. Dermatol.
127
2001-2011
2007
Homo sapiens
Gauss, K.A.; Nelson-Overton, L.K.; Siemsen, D.W.; Gao, Y.; DeLeo, F.R.; Quinn, M.T.
Role of NF-kappaB in transcriptional regulation of the phagocyte NADPH oxidase by tumor necrosis factor-alpha
J. Leukoc. Biol.
82
729-741
2007
Homo sapiens
Paul, R.; Obermaier, B.; Van Ziffle, J.; Angele, B.; Pfister, H.W.; Lowell, C.A.; Koedel, U.
Myeloid Src kinases regulate phagocytosis and oxidative burst in pneumococcal meningitis by activating NADPH oxidase
J. Leukoc. Biol.
84
1141-1150
2008
Mus musculus
Szoecs, K.; Lassegue, B.; Wenzel, P.; Wendt, M.; Daiber, A.; Oelze, M.; Meinertz, T.; Muenzel, T.; Baldus, S.
Increased superoxide production in nitrate tolerance is associated with NAD(P)H oxidase and aldehyde dehydrogenase 2 downregulation
J. Mol. Cell. Cardiol.
42
1111-1118
2007
Rattus norvegicus
Qian, L.; Xu, Z.; Zhang, W.; Wilson, B.; Hong, J.S.; Flood, P.M.
Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase
J. Neuroinflammation
4
23
2007
Rattus norvegicus
Zhang, D.; Hu, X.; Wei, S.; Liu, J.; Gao, H.; Qian, L.; Wilson, B.; Liu, G.; Hong, J.
Squamosamide derivative FLZ protects dopaminergic neurons against inflammation-mediated neurodegeneration through the inhibition of NADPH oxidase activity
J. Neuroinflammation
5
21
2008
Mus musculus, Rattus norvegicus
Park, K.W.; Jin, B.K.
Thrombin-induced oxidative stress contributes to the death of hippocampal neurons: role of neuronal NADPH oxidase
J. Neurosci. Res.
86
1053-1063
2008
Rattus norvegicus
Chiriac, M.T.; Roesler, J.; Sindrilaru, A.; Scharffetter-Kochanek, K.; Zillikens, D.; Sitaru, C.
NADPH oxidase is required for neutrophil-dependent autoantibody-induced tissue damage
J. Pathol.
212
56-65
2007
Homo sapiens, Mus musculus
Schaeppi, M.; Deffert, C.; Fiette, L.; Gavazzi, G.; Herrmann, F.; Belli, D.; Krause, K.H.
Branched fungal beta-glucan causes hyperinflammation and necrosis in phagocyte NADPH oxidase-deficient mice
J. Pathol.
214
434-444
2008
Mus musculus
Teixeira, C.E.; Priviero, F.B.; Webb, R.C.
Effects of 5-cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridine-3-yl]pyrimidin-4-ylamine (BAY 41-2272) on smooth muscle tone, soluble guanylyl cyclase activity, and NADPH oxidase activity/expression in corpus cavernosum from wild-type, neuronal
J. Pharmacol. Exp. Ther.
322
1093-1102
2007
Mus musculus
Steinkamp-Fenske, K.; Bollinger, L.; Xu, H.; Yao, Y.; Horke, S.; Foerstermann, U.; Li, H.
Reciprocal regulation of endothelial nitric-oxide synthase and NADPH oxidase by betulinic acid in human endothelial cells
J. Pharmacol. Exp. Ther.
322
836-842
2007
Homo sapiens
Li, H.; Hortmann, M.; Daiber, A.; Oelze, M.; Ostad, M.A.; Schwarz, P.M.; Xu, H.; Xia, N.; Kleschyov, A.L.; Mang, C.; Warnholtz, A.; Muenzel, T.; Foerstermann, U.
Cyclooxygenase 2-selective and nonselective nonsteroidal anti-inflammatory drugs induce oxidative stress by up-regulating vascular NADPH oxidases
J. Pharmacol. Exp. Ther.
326
745-753
2008
Homo sapiens, Rattus norvegicus
Zhou, J.; Zhang, S.; Zhao, X.; Wei, T.
Melatonin impairs NADPH oxidase assembly and decreases superoxide anion production in microglia exposed to amyloid-beta(1-42)
J. Pineal Res.
45
157-165
2008
Rattus norvegicus
Yang, Y.; Xu, S.; An, L.; Chen, N.
NADPH oxidase-dependent hydrogen peroxide production, induced by salinity stress, may be involved in the regulation of total calcium in roots of wheat
J. Plant Physiol.
164
1429-1435
2007
Triticum aestivum
Hachisuka, H.; Dusting, G.J.; Abberton, K.M.; Morrison, W.A.; Jiang, F.
Role of NADPH oxidase in tissue growth in a tissue engineering chamber in rats
J. Tissue Eng. Regen. Med.
2
430-435
2008
Rattus norvegicus
Terashima, M.; Inoue, N.; Ohashi, Y.; Yokoyama, M.
Relationship between coronary plaque formation and NAD(P)H oxidase-derived reactive oxygen species - comparison of intravascular ultrasound finding of atherosclerotic lesions with histochemical characteristics-
Kobe J. Med. Sci.
53
107-117
2007
Homo sapiens
Wang, J.; Li, L.; Cang, H.; Shi, G.; Yi, J.
NADPH oxidase-derived reactive oxygen species are responsible for the high susceptibility to arsenic cytotoxicity in acute promyelocytic leukemia cells
Leuk. Res.
32
429-436
2008
Homo sapiens
Kim, Y.S.; Morgan, M.J.; Choksi, S.; Liu, Z.G.
TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death
Mol. Cell
26
675-687
2007
Mus musculus
Grasberger, H.; De Deken, X.; Miot, F.; Pohlenz, J.; Refetoff, S.
Missense mutations of dual oxidase 2 (DUOX2) implicated in congenital hypothyroidism have impaired trafficking in cells reconstituted with DUOX2 maturation factor
Mol. Endocrinol.
21
1408-1421
2007
Homo sapiens
Johnson, K.R.; Marden, C.C.; Ward-Bailey, P.; Gagnon, L.H.; Bronson, R.T.; Donahue, L.R.
Congenital hypothyroidism, dwarfism, and hearing impairment caused by a missense mutation in the mouse dual oxidase 2 gene, Duox2
Mol. Endocrinol.
21
1593-1602
2007
Mus musculus
Mayumi, M.; Takeda, Y.; Hoshiko, M.; Serada, K.; Murata, M.; Moritomo, T.; Takizawa, F.; Kobayashi, I.; Araki, K.; Nakanishi, T.; Sumimoto, H.
Characterization of teleost phagocyte NADPH oxidase: molecular cloning and expression analysis of carp (Cyprinus carpio) phagocyte NADPH oxidase
Mol. Immunol.
45
1720-1731
2008
Cyprinus carpio (A7BI57), Cyprinus carpio (A7BI58), Cyprinus carpio (A7BI59), Cyprinus carpio (A7BI60), Cyprinus carpio
Saito, Y.; Geisen, P.; Uppal, A.; Hartnett, M.E.
Inhibition of NAD(P)H oxidase reduces apoptosis and avascular retina in an animal model of retinopathy of prematurity
Mol. Vis.
13
840-853
2007
Rattus norvegicus
Nitti, M.; Furfaro, A.L.; Traverso, N.; Odetti, P.; Storace, D.; Cottalasso, D.; Pronzato, M.A.; Marinari, U.M.; Domenicotti, C.
PKC delta and NADPH oxidase in AGE-induced neuronal death
Neurosci. Lett.
416
261-265
2007
Homo sapiens
Jang, H.J.; Hwang, S.; Cho, K.Y.; Kim, d.o..K.; Chay, K.O.; Kim, J.K.
Taxol induces oxidative neuronal cell death by enhancing the activity of NADPH oxidase in mouse cortical cultures
Neurosci. Lett.
443
17-22
2008
Mus musculus
Anantharam, V.; Kaul, S.; Song, C.; Kanthasamy, A.; Kanthasamy, A.G.
Pharmacological inhibition of neuronal NADPH oxidase protects against 1-methyl-4-phenylpyridinium (MPP+)-induced oxidative stress and apoptosis in mesencephalic dopaminergic neuronal cells
Neurotoxicology
28
988-997
2007
Rattus norvegicus
Potocky, M.; Jones, M.A.; Bezvoda, R.; Smirnoff, N.; Zarsky, V.
Reactive oxygen species produced by NADPH oxidase are involved in pollen tube growth
New Phytol.
174
742-751
2007
Nicotiana tabacum
Stef, G.; Csiszar, A.; Ziangmin, Z.; Ferdinandy, P.; Ungvari, Z.; Veress, G.
Inhibition of NAD(P)H oxidase attenuates aggregation of platelets from high-risk cardiac patients with aspirin resistance
Pharmacol. Rep.
59
428-436
2007
Homo sapiens
Kobayashi, M.; Ohura, I.; Kawakita, K.; Yokota, N.; Fujiwara, M.; Shimamoto, K.; Doke, N.; Yoshioka, H.
Calcium-dependent protein kinases regulate the production of reactive oxygen species by potato NADPH oxidase
Plant Cell
19
1065-1080
2007
Solanum tuberosum
Wong, H.L.; Pinontoan, R.; Hayashi, K.; Tabata, R.; Yaeno, T.; Hasegawa, K.; Kojima, C.; Yoshioka, H.; Iba, K.; Kawasaki, T.; Shimamoto, K.
Regulation of rice NADPH oxidase by binding of Rac GTPase to its N-terminal extension
Plant Cell
19
4022-4034
2007
Oryza sativa
Asai, S.; Ohta, K.; Yoshioka, H.
MAPK signaling regulates nitric oxide and NADPH oxidase-dependent oxidative bursts in Nicotiana benthamiana
Plant Cell
20
1390-1406
2008
Nicotiana benthamiana
Macpherson, N.; Takeda, S.; Shang, Z.; Dark, A.; Mortimer, J.C.; Brownlee, C.; Dolan, L.; Davies, J.M.
NADPH oxidase involvement in cellular integrity
Planta
227
1415-1418
2008
Arabidopsis thaliana
Kumar, G.N.; Iyer, S.; Knowles, N.R.
Strboh A homologue of NADPH oxidase regulates wound-induced oxidative burst and facilitates wound-healing in potato tubers
Planta
227
25-36
2007
Solanum tuberosum
Egan, M.J.; Wang, Z.Y.; Jones, M.A.; Smirnoff, N.; Talbot, N.J.
Generation of reactive oxygen species by fungal NADPH oxidases is required for rice blast disease
Proc. Natl. Acad. Sci. USA
104
11772-11777
2007
Pyricularia grisea
Sabeur, K.; Ball, B.A.
Characterization of NADPH oxidase 5 in equine testis and spermatozoa
Reproduction
134
263-270
2007
Equus caballus
Kahles, T.; Luedike, P.; Endres, M.; Galla, H.J.; Steinmetz, H.; Busse, R.; Neumann-Haefelin, T.; Brandes, R.P.
NADPH oxidase plays a central role in blood-brain barrier damage in experimental stroke
Stroke
38
3000-3006
2007
Mus musculus, Sus scrofa
Riganti, C.; Costamagna, C.; Doublier, S.; Miraglia, E.; Polimeni, M.; Bosia, A.; Ghigo, D.
The NADPH oxidase inhibitor apocynin induces nitric oxide synthesis via oxidative stress
Toxicol. Appl. Pharmacol.
228
277-285
2008
Mus musculus
Shvedova, A.A.; Kisin, E.R.; Murray, A.R.; Kommineni, C.; Castranova, V.; Fadeel, B.; Kagan, V.E.
Increased accumulation of neutrophils and decreased fibrosis in the lung of NADPH oxidase-deficient C57BL/6 mice exposed to carbon nanotubes
Toxicol. Appl. Pharmacol.
231
235-240
2008
Mus musculus
Hwang, J.; Kleinhenz, D.J.; Rupnow, H.L.; Campbell, A.G.; Thule, P.M.; Sutliff, R.L.; Hart, C.M.
The PPARgamma ligand, rosiglitazone, reduces vascular oxidative stress and NADPH oxidase expression in diabetic mice
Vascul. Pharmacol.
46
456-462
2007
Mus musculus
Hamann, T.; Bennett, M.; Mansfield, J.; Somerville, C.
Identification of cell-wall stress as a hexose-dependent and osmosensitive regulator of plant responses
Plant J.
57
1015-1026
2009
Arabidopsis thaliana
Maehara, Y.; Miyano, K.; Sumimoto, H.
Role for the first SH3 domain of p67phox in activation of superoxide-producing NADPH oxidases
Biochem. Biophys. Res. Commun.
379
589-593
2009
Homo sapiens
Cui, X.; Chang, B.; Myatt, L.
Expression and distribution of NADPH oxidase isoforms in human myometrium - role in angiotensin II-induced hypertrophy
Biol. Reprod.
82
305-312
2009
Homo sapiens
Chapuis, J.C.; Khdour, O.; Cai, X.; Lu, J.; Hecht, S.M.
Synthesis and characterization of Deltalac-acetogenins that potently inhibit mitochondrial complex I
Bioorg. Med. Chem.
17
2204-2209
2009
Bos taurus
Luan, R.; Liu, S.; Yin, T.; Lau, W.B.; Wang, Q.; Guo, W.; Wang, H.; Tao, L.
High glucose sensitizes adult cardiomyocytes to ischaemia/reperfusion injury through nitrative thioredoxin inactivation
Cardiovasc. Res.
83
294-302
2009
Mus musculus
Yang, X.Q.; Chen, A.F.
High-cholesterol diet augments endothelial dysfunction via elevated oxidative stress and reduced tetrahydrobiopterin in Ins2(Akita) mice, an autosomal dominant mutant type 1 diabetic model
Clin. Exp. Pharmacol. Physiol.
36
764-769
2009
Mus musculus
Sirichandra, C.; Gu, D.; Hu, H.C.; Davanture, M.; Lee, S.; Djaoui, M.; Valot, B.; Zivy, M.; Leung, J.; Merlot, S.; Kwak, J.M.
Phosphorylation of the Arabidopsis AtrbohF NADPH oxidase by OST1 protein kinase
FEBS Lett.
583
2982-2986
2009
Arabidopsis thaliana
Aram, G.; Potter, J.J.; Liu, X.; Wang, L.; Torbenson, M.S.; Mezey, E.
Deficiency of nicotinamide adenine dinucleotide phosphate, reduced form oxidase enhances hepatocellular injury but attenuates fibrosis after chronic carbon tetrachloride administration
Hepatology
49
911-919
2009
Mus musculus
Luxen, S.; Noack, D.; Frausto, M.; Davanture, S.; Torbett, B.E.; Knaus, U.G.
Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells
J. Cell Sci.
122
1238-1247
2009
Homo sapiens (Q9NRD8), Homo sapiens (Q9NRD9)
Bakri, F.G.; Martel, C.; Khuri-Bulos, N.; Mahafzah, A.; El-Khateeb, M.S.; Al-Wahadneh, A.M.; Hayajneh, W.A.; Hamamy, H.A.; Maquet, E.; Molin, M.; Stasia, M.J.
First report of clinical, functional, and molecular investigation of chronic granulomatous disease in nine Jordanian families
J. Clin. Immunol.
29
215-230
2009
Homo sapiens
Kamizato, M.; Nishida, K.; Masuda, K.; Takeo, K.; Yamamoto, Y.; Kawai, T.; Teshima-Kondo, S.; Tanahashi, T.; Rokutan, K.
Interleukin 10 inhibits interferon gamma- and tumor necrosis factor alpha-stimulated activation of NADPH oxidase 1 in human colonic epithelial cells and the mouse colon
J. Gastroenterol.
44
1172-1184
2009
Homo sapiens
Chao, H.H.; Chen, C.H.; Liu, J.C.; Lin, J.W.; Wong, K.L.; Cheng, T.H.
L-Carnitine attenuates angiotensin II-induced proliferation of cardiac fibroblasts: role of NADPH oxidase inhibition and decreased sphingosine-1-phosphate generation
J. Nutr. Biochem.
21
580-588
2010
Rattus norvegicus
Keith, K.E.; Hynes, D.W.; Sholdice, J.E.; Valvano, M.A.
Delayed association of the NADPH oxidase complex with macrophage vacuoles containing the opportunistic pathogen Burkholderia cenocepacia
Microbiology
155
1004-1015
2009
Homo sapiens
Zhang, F.; Zhang, Y.; Li, P.L.
Dependence of cathepsin L-induced coronary endothelial dysfunction upon activation of NAD(P)H oxidase
Microvasc. Res.
78
45-50
2009
Bos taurus
Jensen, M.D.; Sheng, W.; Simonyi, A.; Johnson, G.S.; Sun, A.Y.; Sun, G.Y.
Involvement of oxidative pathways in cytokine-induced secretory phospholipase A2-IIA in astrocytes
Neurochem. Int.
55
362-368
2009
Rattus norvegicus
Haruta, M.; Bush, R.A.; Kjellstrom, S.; Vijayasarathy, C.; Zeng, Y.; Le, Y.Z.; Sieving, P.A.
Depleting Rac1 in mouse rod photoreceptors protects them from photo-oxidative stress without affecting their structure or function
Proc. Natl. Acad. Sci. USA
106
9397-9402
2009
Mus musculus
Arora, S.; Vaishya, R.; Dabla, P.K.; Singh, B.
NAD(P)H oxidases in coronary artery disease
Adv. Clin. Chem.
50
65-86
2010
Oryctolagus cuniculus, Homo sapiens, Mus musculus
Matsushima, S.; Kinugawa, S.; Yokota, T.; Inoue, N.; Ohta, Y.; Hamaguchi, S.; Tsutsui, H.
Increased myocardial NAD(P)H oxidase-derived superoxide causes the exacerbation of postinfarct heart failure in type 2 diabetes
Am. J. Physiol. Heart Circ. Physiol.
297
H409-H416
2009
Mus musculus
Muller, G.; Morawietz, H.
Nitric oxide, NAD(P)H oxidase, and atherosclerosis
Antioxid. Redox Signal.
11
1711-1731
2009
Homo sapiens
Piwkowska, A.; Rogacka, D.; Jankowski, M.; Dominiczak, M.H.; Stepi?ski, J.K.; Angielski, S.
Metformin induces suppression of NAD(P)H oxidase activity in podocytes
Biochem. Biophys. Res. Commun.
393
268-273
2010
Mus musculus
El-Benna, J.; Dang, P.M.; Perianin, A.
Peptide-based inhibitors of the phagocyte NADPH oxidase
Biochem. Pharmacol.
80
778-785
2010
Homo sapiens, Rattus norvegicus
Pan, Q.; Yang, X.H.; Cheng, Y.X.
Angiotensin II stimulates MCP-1 production in rat glomerular endothelial cells via NAD(P)H oxidase-dependent nuclear factor-kappa B signaling
Braz. J. Med. Biol. Res.
42
531-536
2009
Rattus norvegicus
Gao, L.; Mann, G.E.
Vascular NAD(P)H oxidase activation in diabetes: a double-edged sword in redox signalling
Cardiovasc. Res.
82
9-20
2009
Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus
Ben Mkaddem, S.; Pedruzzi, E.; Werts, C.; Coant, N.; Bens, M.; Cluzeaud, F.; Goujon, J.; Ogier-Denis, E.; Vandewalle, A.
Heat shock protein gp96 and NAD(P)H oxidase 4 play key roles in Toll-like receptor 4-activated apoptosis during renal ischemia/reperfusion injury
Cell Death Differ.
17
1474-1485
2010
Mus musculus
Winiarska, K.; Grabowski, M.; Rogacki, M.K.
Inhibition of renal gluconeogenesis contributes to hypoglycaemic action of NADPH oxidase inhibitor, apocynin
Chem. Biol. Interact.
189
119-126
2011
Oryctolagus cuniculus, Rattus norvegicus
Wang, S.; Zhang, M.; Liang, B.; Xu, J.; Xie, Z.; Liu, C.; Viollet, B.; Yan, D.; Zou, M.H.
AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomes
Circ. Res.
106
1117-1128
2010
Homo sapiens, Mus musculus
Saitoh, Y.; Hongwei, W.; Ueno, H.; Mizuta, M.; Nakazato, M.
Telmisartan attenuates fatty-acid-induced oxidative stress and NAD(P)H oxidase activity in pancreatic beta-cells
Diabetes Metab.
35
392-397
2009
Mus musculus
Morgan, D.; Rebelato, E.; Abdulkader, F.; Graciano, M.F.; Oliveira-Emilio, H.R.; Hirata, A.E.; Rocha, M.S.; Bordin, S.; Curi, R.; Carpinelli, A.R.
Association of NAD(P)H oxidase with glucose-induced insulin secretion by pancreatic beta-cells
Endocrinology
150
2197-2201
2009
Rattus norvegicus
Olekhnovich, I.N.; Goodwin, A.; Hoffman, P.S.
Characterization of the NAD(P)H oxidase and metronidazole reductase activities of the RdxA nitroreductase of Helicobacter pylori
FEBS J.
276
3354-3364
2009
Helicobacter pylori, Helicobacter pylori G27 and SS1
Feillet-Coudray, C.; Sutra, T.; Fouret, G.; Ramos, J.; Wrutniak-Cabello, C.; Cabello, G.; Cristol, J.P.; Coudray, C.
Oxidative stress in rats fed a high-fat high-sucrose diet and preventive effect of polyphenols: Involvement of mitochondrial and NAD(P)H oxidase systems
Free Radic. Biol. Med.
46
624-632
2009
Rattus norvegicus
Maraldi, T.; Prata, C.; Vieceli Dalla Sega, F.; Caliceti, C.; Zambonin, L.; Fiorentini, D.; Hakim, G.
NAD(P)H oxidase isoform Nox2 plays a prosurvival role in human leukaemia cells
Free Radic. Res.
43
1111-1121
2009
Homo sapiens
Zhang, R.; Harding, P.; Garvin, J.L.; Juncos, R.; Peterson, E.; Juncos, L.A.; Liu, R.
Isoforms and functions of NAD(P)H oxidase at the macula densa
Hypertension
53
556-563
2009
Rattus norvegicus (Q924V1)
Bhandarkar, S.S.; Jaconi, M.; Fried, L.E.; Bonner, M.Y.; Lefkove, B.; Govindarajan, B.; Perry, B.N.; Parhar, R.; Mackelfresh, J.; Sohn, A.; Stouffs, M.; Knaus, U.; Yancopoulos, G.; Reiss, Y.; Benest, A.V.; Augustin, H.G.; Arbiser, J.L.
Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice
J. Clin. Invest.
119
2359-2365
2009
Mus musculus
McCaffrey, R.L.; Schwartz, J.T.; Lindemann, S.R.; Moreland, J.G.; Buchan, B.W.; Jones, B.D.; Allen, L.A.
Multiple mechanisms of NADPH oxidase inhibition by type A and type B Francisella tularensis
J. Leukoc. Biol.
88
791-805
2010
Homo sapiens
Borbely, G.; Szabadkai, I.; Horvath, Z.; Marko, P.; Varga, Z.; Breza, N.; Baska, F.; Vantus, T.; Huszar, M.; Geiszt, M.; Hunyady, L.; Buday, L.; Orfi, L.; Keri, G.
Small-molecule inhibitors of NADPH oxidase 4
J. Med. Chem.
53
6758-6762
2010
Homo sapiens
Laleu, B.; Gaggini, F.; Orchard, M.; Fioraso-Cartier, L.; Cagnon, L.; Houngninou-Molango, S.; Gradia, A.; Duboux, G.; Merlot, C.; Heitz, F.; Szyndralewiez, C.; Page, P.
First in class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitors for the treatment of idiopathic pulmonary fibrosis
J. Med. Chem.
53
7715-7730
2010
Homo sapiens
Zhang, Q.G.; Raz, L.; Wang, R.; Han, D.; De Sevilla, L.; Yang, F.; Vadlamudi, R.K.; Brann, D.W.
Estrogen attenuates ischemic oxidative damage via an estrogen receptor alpha-mediated inhibition of NADPH oxidase activation
J. Neurosci.
29
13823-13836
2009
Rattus norvegicus
Kleinschnitz, C.; Grund, H.; Wingler, K.; Armitage, M.E.; Jones, E.; Mittal, M.; Barit, D.; Schwarz, T.; Geis, C.; Kraft, P.; et al
Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration
PLoS Biol.
8
e1000479
2010
Homo sapiens, Mus musculus
Loughlin, D.T.; Artlett, C.M.
Precursor of advanced glycation end products mediates ER-stress-induced caspase-3 activation of human dermal fibroblasts through NAD(P)H oxidase 4
PLoS ONE
5
e11093
2010
Homo sapiens
Gupte, S.; Labinskyy, N.; Gupte, R.; Csiszar, A.; Ungvari, Z.; Edwards, J.G.
Role of NAD(P)H oxidase in superoxide generation and endothelial dysfunction in Goto-Kakizaki (GK) rats as a model of nonobese NIDDM
PLoS ONE
5
e11800
2010
Rattus norvegicus
Polizio, A.H.; Balestrasse, K.B.; Gornalusse, G.G.; Gorzalczany, S.B.; Santa-Cruz, D.M.; Yannarelli, G.G.; Pena, C.; Tomaro, M.L.
Losartan exerts renoprotection through NAD(P)H oxidase downregulation in a renovascular model of hypertension
Regul. Pept.
156
28-33
2009
Rattus norvegicus
Zia, M.T.; Csiszar, A.; Labinskyy, N.; Hu, F.; Vinukonda, G.; LaGamma, E.F.; Ungvari, Z.; Ballabh, P.
Oxidative-nitrosative stress in a rabbit pup model of germinal matrix hemorrhage: role of NAD(P)H oxidase
Stroke
40
2191-2198
2009
Oryctolagus cuniculus
Arcari, P.; Masullo, L.; Masullo, M.; Catanzano, F.; Bocchini, V.
A NAD(P)H oxidase isolated from the archaeon Sulfolobus solfataricus is not homologous with another NADH oxidase present in the same microorganism. Biochemical characterization of the enzyme and cloning of the encoding gene
J. Biol. Chem.
275
895-900
2000
Saccharolobus solfataricus, Saccharolobus solfataricus MT-4 / DSM 5833
Montero-Barrientos, M.; Hermosa, R.; Cardoza, R.E.; Gutierrez, S.; Monte, E.
Functional analysis of the Trichoderma harzianum nox1 gene, encoding an NADPH oxidase, relates production of reactive oxygen species to specific biocontrol activity against Pythium ultimum
Appl. Environ. Microbiol.
77
3009-3016
2011
Trichoderma harzianum (F4ZCJ9), Trichoderma harzianum T34 (F4ZCJ9)
Kim, H.J.; Chen, C.; Kabbage, M.; Dickman, M.B.
Identification and characterization of Sclerotinia sclerotiorum NADPH oxidases
Appl. Environ. Microbiol.
77
7721-7729
2011
Sclerotinia sclerotiorum, Sclerotinia sclerotiorum 1980
Wu, X.; Kobori, H.; Orita, I.; Zhang, C.; Imanaka, T.; Xing, X.H.; Fukui, T.
Application of a novel thermostable NAD(P)H oxidase from hyperthermophilic archaeon for the regeneration of both NAD+ and NADP+
Biotechnol. Bioeng.
109
53-62
2012
Thermococcus kodakarensis (Q5JFZ8)
El-Benna, J.; Dang, P.M.; Perianin, A.
Towards specific NADPH oxidase inhibition by small synthetic peptides
Cell. Mol. Life Sci.
69
2307-2314
2012
Homo sapiens
Lassegue, B.; San Martin, A.; Griendling, K.K.
Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system
Circ. Res.
110
1364-1390
2012
Homo sapiens
Gaete, P.S.; Lillo, M.A.; Ardiles, N.M.; Perez, F.R.; Figueroa, X.F.
Ca2+-activated K+ channels of small and intermediate conductance control eNOS activation through NAD(P)H oxidase
Free Radic. Biol. Med.
52
860-870
2012
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Zhao, R.; Le, K.; Moghadasian, M.H.; Shen, G.X.
Regulatory role of NADPH oxidase in glycated LDL-induced upregulation of plasminogen activator inhibitor-1 and heat shock factor-1 in mouse embryo fibroblasts and diabetic mice
Free Radic. Biol. Med.
61C
18-25
2013
Mus musculus, Mus musculus C57BL/6
Asai, S.; Ichikawa, T.; Nomura, H.; Kobayashi, M.; Kamiyoshihara, Y.; Mori, H.; Kadota, Y.; Zipfel, C.; Jones, J.D.; Yoshioka, H.
The variable domain of a plant calcium-dependent protein kinase (CDPK) confers subcellular localization and substrate recognition for NADPH oxidase
J. Biol. Chem.
288
14332-14340
2013
Solanum tuberosum
Wei, C.C.; Motl, N.; Levek, K.; Chen, L.Q.; Yang, Y.P.; Johnson, T.; Hamilton, L.; Stuehr, D.J.
Conformational States and kinetics of the calcium binding domain of NADPH oxidase 5
Open Biochem. J.
4
59-67
2010
Homo sapiens
Harnvoravongchai, P.; Kobori, H.; Orita, I.; Nakamura, S.; Imanaka, T.; Fukui, T.
Characterization and gene deletion analysis of four homologues of group 3 pyridine nucleotide disulfide oxidoreductases from Thermococcus kodakarensis
Extremophiles
18
603-616
2014
Thermococcus kodakarensis (Q5JFZ8), Thermococcus kodakarensis (Q5JGF8), Thermococcus kodakarensis (Q5JGP4), Thermococcus kodakarensis (Q5JHY2), Thermococcus kodakarensis (Q5JJB9), Thermococcus kodakarensis
Azouzi, N.; Cailloux, J.; Cazarin, J.M.; Knauf, J.A.; Cracchiolo, J.; Al Ghuzlan, A.; Hartl, D.; Polak, M.; Carre, A.; El Mzibri, M.; Filali-Maltouf, A.; Al Bouzidi, A.; Schlumberger, M.; Fagin, J.A.; Ameziane-El-Hassani, R.; Dupuy, C.
NADPH oxidase NOX4 is a critical mediator of BRAF(V600E)-induced downregulation of the sodium/iodide symporter in papillary thyroid carcinomas
Antioxid. Redox Signal.
26
864-877
2017
Homo sapiens
Kawarazaki, T.; Kimura, S.; Iizuka, A.; Hanamata, S.; Nibori, H.; Michikawa, M.; Imai, A.; Abe, M.; Kaya, H.; Kuchitsu, K.
A low temperature-inducible protein AtSRC2 enhances the ROS-producing activity of NADPH oxidase AtRbohF
Biochim. Biophys. Acta
1833
2775-2780
2013
Arabidopsis thaliana
Souabni, H.; Wien, F.; Bizouarn, T.; Houee-Levin, C.; Refregiers, M.; Baciou, L.
The physicochemical properties of membranes correlate with the NADPH oxidase activity
Biochim. Biophys. Acta
1861
3520-3530
2017
Komagataella pastoris
Gandara, A.C.; Torres, A.; Bahia, A.C.; Oliveira, P.L.; Schama, R.
Evolutionary origin and function of NOX4-art, an arthropod specific NADPH oxidase
BMC Evol. Biol.
17
92
2017
Aedes aegypti
Cachat, J.; Deffert, C.; Hugues, S.; Krause, K.H.
Phagocyte NADPH oxidase and specific immunity
Clin. Sci.
128
635-648
2015
Homo sapiens
De Blasio, M.J.; Ramalingam, A.; Cao, A.H.; Prakoso, D.; Ye, J.M.; Pickering, R.; Watson, A.M.D.; de Haan, J.B.; Kaye, D.M.; Ritchie, R.H.
The superoxide dismutase mimetic tempol blunts diabetes-induced upregulation of NADPH oxidase and endoplasmic reticulum stress in a rat model of diabetic nephropathy
Eur. J. Pharmacol.
807
12-20
2017
Rattus norvegicus
Antony, S.; Wu, Y.; Hewitt, S.M.; Anver, M.R.; Butcher, D.; Jiang, G.; Meitzler, J.L.; Liu, H.; Juhasz, A.; Lu, J.; Roy, K.K.; Doroshow, J.H.
Characterization of NADPH oxidase 5 expression in human tumors and tumor cell lines with a novel mouse monoclonal antibody
Free Radic. Biol. Med.
65
497-508
2013
Homo sapiens
Matsumoto, M.; Katsuyama, M.; Iwata, K.; Ibi, M.; Zhang, J.; Zhu, K.; Nauseef, W.M.; Yabe-Nishimura, C.
Characterization of N-glycosylation sites on the extracellular domain of NOX1/NADPH oxidase
Free Radic. Biol. Med.
68
196-204
2014
Homo sapiens, Mus musculus, Rattus norvegicus
Donko, A.; Morand, S.; Korzeniowska, A.; Boudreau, H.E.; Zana, M.; Hunyady, L.; Geiszt, M.; Leto, T.L.
Hypothyroidism-associated missense mutation impairs NADPH oxidase activity and intracellular trafficking of Duox2
Free Radic. Biol. Med.
73
190-200
2014
Mus musculus
Cooney, S.J.; Zhao, Y.; Byrnes, K.R.
Characterization of the expression and inflammatory activity of NADPH oxidase after spinal cord injury
Free Radic. Res.
48
929-939
2014
Rattus norvegicus
Chen, F.; Yin, C.; Dimitropoulou, C.; Fulton, D.J.
Cloning, characteristics, and functional analysis of rabbit NADPH oxidase 5
Front. Physiol.
7
284
2016
Oryctolagus cuniculus
Bermudez, S.; Khayrullina, G.; Zhao, Y.; Byrnes, K.R.
NADPH oxidase isoform expression is temporally regulated and may contribute to microglial/macrophage polarization after spinal cord injury
Mol. Cell. Neurosci.
77
53-64
2016
Mus musculus
Nestler, J.; Liu, S.; Wen, T.J.; Paschold, A.; Marcon, C.; Tang, H.M.; Li, D.; Li, L.; Meeley, R.B.; Sakai, H.; Bruce, W.; Schnable, P.S.; Hochholdinger, F.
Roothairless5, which functions in maize (Zea mays L.) root hair initiation and elongation encodes a monocot-specific NADPH oxidase
Plant J.
79
729-740
2014
Zea mays
Zhang, J.; Chen, C.; Zhang, D.; Li, H.; Li, P.; Ma, F.
Reactive oxygen species produced via plasma membrane NADPH oxidase regulate anthocyanin synthesis in apple peel
Planta
240
1023-1035
2014
Malus domestica
van der Hoeven, R.; Cruz, M.R.; Chavez, V.; Garsin, D.A.
Localization of the dual oxidase BLI-3 and characterization of its NADPH oxidase domain during infection of Caenorhabditis elegans
PLoS ONE
10
e0124091
2015
Caenorhabditis elegans
Ameziane-El-Hassani, R.; Talbot, M.; de Souza Dos Santos, M.C.; Al Ghuzlan, A.; Hartl, D.; Bidart, J.M.; De Deken, X.; Miot, F.; Diallo, I.; de Vathaire, F.; Schlumberger, M.; Dupuy, C.
NADPH oxidase DUOX1 promotes long-term persistence of oxidative stress after an exposure to irradiation
Proc. Natl. Acad. Sci. USA
112
5051-5056
2015
Homo sapiens
Magnani, F.; Nenci, S.; Millana Fananas, E.; Ceccon, M.; Romero, E.; Fraaije, M.W.; Mattevi, A.
Crystal structures and atomic model of NADPH oxidase
Proc. Natl. Acad. Sci. USA
114
6764-6769
2017
Cylindrospermum stagnale (K9WT99), Cylindrospermum stagnale PCC 7417 (K9WT99)
Libik-Konieczny, M.; Kozieradzka-Kiszkurno, M.; Desel, C.; Michalec-Warzecha, ?.; Miszalski, Z.; Konieczny, R.
The localization of NADPH oxidase and reactive oxygen species in in vitro-cultured Mesembryanthemum crystallinum L. hypocotyls discloses their differing roles in rhizogenesis
Protoplasma
252
477-487
2015
Mesembryanthemum crystallinum
Li, M.; Wang, J.; Song, S.; Li, C.
Molecular characterization of a novel nitric oxide synthase gene from Portunus trituberculatus and the roles of NO/O2(-)- generating and antioxidant systems in host immune responses to Hematodinium
Fish Shellfish Immunol.
52
263-277
2016
Portunus trituberculatus (A0A145P6Q3)
Al-Harbi, N.O.; Nadeem, A.; Ansari, M.A.; Al-Harbi, M.M.; Alotaibi, M.R.; AlSaad, A.M.; Ahmad, S.F.
Psoriasis-like inflammation leads to renal dysfunction via upregulation of NADPH oxidases and inducible nitric oxide synthase
Int. Immunopharmacol.
46
1-8
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Mus musculus (Q9JHI8)
Cortes, A.; Pejenaute, A.; Marques, J.; Izal, I.; Cenoz, S.; Ansorena, E.; Martinez-Irujo, J.J.; de Miguel, C.; Zalba, G.
NADPH oxidase 5 induces changes in the unfolded protein response in human aortic endothelial cells and in endothelial-specific knock-in mice
Antioxidants (Basel)
10
194
2021
Homo sapiens (Q96PH1), Homo sapiens
Dakik, H.; El Dor, M.; Leclerc, J.; Kouzi, F.; Nehme, A.; Deynoux, M.; Debeissat, C.; Khamis, G.; Ducrocq, E.; Ibrik, A.; Stasia, M.J.; Raad, H.; Rezvani, H.R.; Gouilleux, F.; Zibara, K.; Herault, O.; Mazurier, F.
Characterization of NADPH oxidase expression and activity in acute myeloid leukemia cell lines A correlation with the differentiation status
Antioxidants (Basel)
10
498
2021
Homo sapiens (P04839)
Sadri, S.; Tomar, N.; Yang, C.; Audi, S.H.; Cowley, A.W.; Dash, R.K.
Mechanistic computational modeling of the kinetics and regulation of NADPH oxidase 2 assembly and activation facilitating superoxide production
Free Radic. Res.
54
695-721
2020
Homo sapiens (P04839)
Quesada, I.; de Paola, M.; Alvarez, M.S.; Hapon, M.B.; Gamarra-Luques, C.; Castro, C.
Antioxidant and anti-atherogenic properties of Prosopis strombulifera and Tessaria absinthioides aqueous extracts modulation of NADPH oxidase-derived reactive oxygen species
Front. Physiol.
12
662833
2021
Mus musculus, Rattus norvegicus
Ranjan, A.; Jayaraman, D.; Grau, C.; Hill, J.; Whitham, S.; Ane, J.; Smith, D.; Kabbage, M.
The pathogenic development of Sclerotinia sclerotiorum in soybean requires specific host NADPH oxidases
Mol. Plant Pathol.
19
700-714
2018
Glycine max (A0A0R0HTY5), Glycine max (I1JRB1), Glycine max (I1NBY2), Glycine max (K7N5A2)
Kharbech, O.; Ben Massoud, M.; Sakouhi, L.; Djebali, W.; Jose Mur, L.A.; Chaoui, A.
Exogenous application of hydrogen sulfide reduces chromium toxicity in maize seedlings by suppressing NADPH oxidase activities and methylglyoxal accumulation
Plant Physiol. Biochem.
154
646-656
2020
Zea mays
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