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Literature summary for 1.6.3.1 extracted from
- Role of the small GTPase Rac in p22phox-dependent NADPH oxidases (2007), Biochimie, 89, 1133-1144.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Rac | small GTPase Rac plays a positive role in isoform Nox3 activation in the presence of subunit p47phox and either subunits p67phox or Noxa1, whereas Rac fails to upregulate Nox3 activity when p47phox is replaced with Noxo1. Expression of constitutively active Rac1 mutant Q61L enhances not only superoxide production but also membrane translocation of p67phox | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in HeLa cells and COS-7 cells | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | small GTPase Rac is involved in membrane translocation of subunit p67phox | Homo sapiens | 16020 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
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