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Literature summary for 1.6.3.1 extracted from

  • Dupuy, C.; Ohayon, R.; Valent, A.; Noel-Hudson, M.S.; Deme, D.; Virion, A.
    Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cDNAs (1999), J. Biol. Chem., 274, 37265-37269.
    View publication on PubMed
Search for more literature for 1.6.3.1

Cloned(Commentary)

Cloned (Comment) Organism
cloning of full length cDNA Homo sapiens
cloning of full length cDNA Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
apical plasma membrane
-
 Homo sapiens 16324
-
apical plasma membrane
-
 Sus scrofa 16324
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required for full activity Homo sapiens
Ca2+ required for full activity Sus scrofa
Ca2+ regulates enzyme activity Homo sapiens
Ca2+ regulates enzyme activity Sus scrofa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
138000
-
 calculated from cDNA sequence Homo sapiens
138000
-
 calculated from cDNA sequence Sus scrofa
180000
-
 SDS-PAGE, two minor bands at 150000 and 130000 Da Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD(P)H + H+ + O2 Caenorhabditis elegans
-
 NAD(P)+ + H2O2
-
 ?
NAD(P)H + H+ + O2 Homo sapiens production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis NAD(P)+ + H2O2
-
 ?
NAD(P)H + H+ + O2 Sus scrofa production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis NAD(P)+ + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans O61213 high sequence similarities to mammalian proteins
-
Homo sapiens Q9NRD8
-
-
Sus scrofa Q8HZK2
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
thyroid gland
-
 Homo sapiens
-
thyroid gland
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD(P)H + H+ + O2
-
 Homo sapiens NAD(P)+ + H2O2
-
 ?
NAD(P)H + H+ + O2
-
 Caenorhabditis elegans NAD(P)+ + H2O2
-
 ?
NAD(P)H + H+ + O2
-
 Sus scrofa NAD(P)+ + H2O2
-
 ?
NAD(P)H + H+ + O2 production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis Homo sapiens NAD(P)+ + H2O2
-
 ?
NAD(P)H + H+ + O2 production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis Sus scrofa NAD(P)+ + H2O2
-
 ?

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Homo sapiens
FAD flavoprotein Sus scrofa
NADPH binding site Homo sapiens
NADPH binding site Sus scrofa