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Information on EC 3.5.99.6 - glucosamine-6-phosphate deaminase

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IUBMB Comments
The enzyme uses ring opening and isomerization of the aldose-ketose type to convert the -CH(-NH2)-CH=O group of glucosamine 6-phosphate into -C(=NH)-CH2-OH, forming 2-deoxy-2-imino-D-arabino-hexitol, which then hydrolyses to yield fructose 6-phosphate and ammonia. N-Acetyl-D-glucosamine 6-phosphate, which is not broken down, activates the enzyme.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol-isomerizing), 2-amino-2-deoxy-D-glucose-6-phosphate ketol isomerase (deaminating), 5.3.1.10, aminodeoxyglucosephosphate isomerase, EC 5.3.1.10, GlcN-6-P isomerase, GlcN6P deaminase, glucosamine 6-phosphate deaminase, glucosamine 6-phosphate isomerase, glucosamine phosphate deaminase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
alpha-D-glucosamine 6-phosphate + H2O = D-fructose 6-phosphate + NH3
show the reaction diagram
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