Reference on EC 1.6.1.2 - NAD(P)+ transhydrogenase (Re/Si-specific)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hoek, J.B.; Rydström, J.; Höjeberg, B.
Comparative studies on nicotinamide nucleotide transhydrogenase from different sources
Biochim. Biophys. Acta
333
237-245
1974
Escherichia coli
Manually annotated by BRENDA team
Jackson, J.B.; Lever, T.M.; Rydström, J.; Persson, B.; Carlenor, E.
Proton-translocating transhydrogenase from photosynthetic bacteria
Biochem. Soc. Trans.
19
573-575
1991
Escherichia coli, Mammalia
Manually annotated by BRENDA team
Rydström, J.; Hoek, J.B.; Ernster, L.
Nicotinamide nucleotide transhydrogenases
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
13
51-88
1976
Bos taurus, Mammalia
-
Manually annotated by BRENDA team
Yamaguchi, M.; Hatefi, Y.
Mitochondrial energy-linked nicotinamide nucleotide transhydrogenase. Membrane topography of the bovine enzyme
J. Biol. Chem.
266
5728-5735
1991
Bos taurus
Manually annotated by BRENDA team
Yamaguchi, M.; Hatefi, Y.
Mitochondrial nicotinamide nucleotide transhydrogenase: NADPH binding increases and NADP binding decreases the acidity and susceptibility to modification of cysteine-893
Biochemistry
28
6050-6056
1989
Bos taurus
Manually annotated by BRENDA team
Yamaguchi, M.; Hatefi, Y.; Trach, K.; Hoch, J.A.
Amino acid sequence of the signal peptide of mitochondrial nicotinamide nucleotide transhydrogenase as determined from the sequence of its messenger RNA
Biochem. Biophys. Res. Commun.
157
24-29
1988
Bos taurus
Manually annotated by BRENDA team
Hoek, J.B.; Rydström, J.
Physiological roles of nicotinamide nucleotide transhydrogenase
Biochem. J.
254
1-10
1988
Mammalia
Manually annotated by BRENDA team
Yamaguchi, M.; Hatefi, Y.; Trach, K.; Hoch, J.A.
The primary structure of the mitochondrial energy-linked nicotinamide nucleotide transhydrogenase deduced from the sequence of cDNA clones
J. Biol. Chem.
263
2761-2767
1988
Bos taurus
Manually annotated by BRENDA team
Persson, B.; Ahnström, G.; Rydström, J.
Energy-linked nicotinamide nucleotide transhydrogenase: hydrodynamic properties and active form of purified and membrane-bound mitochondrial transhydrogenase from beef heart
Arch. Biochem. Biophys.
259
341-349
1987
Bos taurus
Manually annotated by BRENDA team
Weis, J.K.; Wu, L.N.Y.; Fisher, R.R.
The orientation of transhydrogenase in the inner mitochondrial membrane of rat liver
Arch. Biochem. Biophys.
257
424-429
1987
Rattus norvegicus
Manually annotated by BRENDA team
Eytan, G.D.; Eytan, E.; Rydström, J.
Energy-linked nicotinamide-nucleotide transhydrogenase. Light-driven transhydrogenase catalyzed by transhydrogenase from beef heart mitochondria reconstituted with bacteriorhodopsin
J. Biol. Chem.
262
5015-5019
1987
Bos taurus
Manually annotated by BRENDA team
Eytan, G.D.; Persson, B.; Ekebacke, A.; Rydström, J.
Energy-linked nicotinamide-nucleotide transhydrogenase. Characterization of reconstituted ATP-driven transhydrogenase from beef heart mitochondria
J. Biol. Chem.
262
5008-5014
1987
Bos taurus
Manually annotated by BRENDA team
Persson, B.; Rydström, J.
Evidence for a role of a vicinal dithiol in catalysis and proton pumping in mitochondrial nicotinamide nucleotide transhydrogenase
Biochem. Biophys. Res. Commun.
142
573-578
1987
Bos taurus
Manually annotated by BRENDA team
Moody, A.J.
Identification of the nicotinamide nucleotide transhydrogenase of rat liver mitochondria
Biochem. Soc. Trans.
14
1210-1212
1986
Rattus norvegicus
-
Manually annotated by BRENDA team
Clarke, D.M.; Loo, T.W.; Gillam, S.; Bragg, P.D.
Nucleotide sequence of the pntA and pntB genes encoding the pyridine nucleotide transhydrogenase of Escherichia coli
Eur. J. Biochem.
158
647-653
1986
Escherichia coli
Manually annotated by BRENDA team
Wu, L.N.Y.; Alberta, J.A.; Fisher, R.R.
Purification and reconstitution of bovine heart mitochondrial transhydrogenase
Methods Enzymol.
126
353-360
1986
Bos taurus
Manually annotated by BRENDA team
Nore, B.F.; Husain, I.; Nyren, P.; Baltscheffsky, M.
Synthesis of pyrophosphate coupled to the reverse energy-linked transhydrogenase reaction in Rhodospirillum rubrum chromatophores
FEBS Lett.
200
133-138
1986
Rhodospirillum rubrum
Manually annotated by BRENDA team
Clarke, D.M.; Bragg, P.D.
Expression of the cloned subunits of Escherichia coli transhydrogenase from separate replicons
FEBS Lett.
200
23-26
1986
Escherichia coli
Manually annotated by BRENDA team
Yamaguchi, M.; Hatefi, Y.
Mitochondrial nicotinamide nucleotide transhydrogenase: inhibition by ethoxyformic anhydride, dansyl chloride, and pyridoxal phosphate
Arch. Biochem. Biophys.
243
20-27
1985
Bos taurus
Manually annotated by BRENDA team
Phelps, D.C.; Hatefi, Y.
Mitochondrial nicotinamide nucleotide transhydrogenase: nonidentical modification by N,N-dicyclohexylcarbodiimide and N-(ethoxycarbonyl)-2-ethoxy-1,2-dihydroquinoline at the NAD(H) binding site
Arch. Biochem. Biophys.
243
298-304
1985
Bos taurus
Manually annotated by BRENDA team
Carlenor, E.; Tang, H.L.; Rydström, J.
Affinity chromatography of mitochondrial nicotinamide nucleotide transhydrogenase
Anal. Biochem.
148
518-523
1985
Bos taurus, Rattus norvegicus
Manually annotated by BRENDA team
Phelps, D.C.; Hatefi, Y.
Mitochondrial nicotinamide nucleotide transhydrogenase: active site modification by 5-[p-(fluorosulfonyl)benzoyl]adenosine
Biochemistry
24
3503-3507
1985
Bos taurus
Manually annotated by BRENDA team
Kozlov, I.A.; Milgrom, Y.M.; Saburova, L.A.; Sobolev, A.Y.
The interaction of mitochondrial transhydrogenase with derivatives of coenzyme A
Eur. J. Biochem.
145
413-416
1984
Bos taurus
Manually annotated by BRENDA team
Phelps, D.C.; Hatefi, Y.
Interaction of purified nicotinamidenucleotide transhydrogenase with dicyclohexylcarbodiimide
Biochemistry
23
4475-4480
1984
Bos taurus
Manually annotated by BRENDA team
Persson, B.; Enander, K.; Tang, H.L.; Rydström, J.
Energy-linked nicotinamide nucleotide transhydrogenase. Properties of proton-translocating mitochondrial transhydrogenase from beef heart purified by fast protein liquid chromatography
J. Biol. Chem.
259
8626-8632
1984
Bos taurus
Manually annotated by BRENDA team
Pennington, R.M.; Fisher, R.R.
Reconstituted mitochondrial transhydrogenase is a transmembrane protein
FEBS Lett.
164
345-349
1983
Bos taurus
Manually annotated by BRENDA team
Moody, A.J.; Reid, R.A.
Inhibition of nicotinamide nucleotide transhydrogenase in rat liver submitochondrial particles by dicyclohexylcarbodi-imide and butanedione
Biochem. J.
209
889-892
1983
Rattus norvegicus
Manually annotated by BRENDA team
Wu, L.N.W.; Fisher, R.R.
Subunit structure of submitochondrial particle membrane transhydrogenase
J. Biol. Chem.
258
7847-7851
1983
Bos taurus
Manually annotated by BRENDA team
Enander, K.; Rydström, J.
Energy-linked nicotinamide nucleotide transhydrogenase. Kinetics and regulation of purified and reconstituted transhydrogenase from beef heart mitochondria
J. Biol. Chem.
257
14760-14766
1982
Bos taurus
Manually annotated by BRENDA team
Wu, L.N.Y.; Fisher, R.R.
Stereochemistry of NADPH leads to NADP+ transhydrogenation catalyzed by bovine heart mitochondrial pyridine dinucleotide transhydrogenase
J. Biol. Chem.
257
11680-11683
1982
Bos taurus
Manually annotated by BRENDA team
Wu, L.N.Y.; Pennington, R.M.; Everett, T.D.; Fisher, R.R.
An improved method for the purification of bovine heart mitochondrial transhydrogenase
J. Biol. Chem.
257
4052-4055
1982
Bos taurus
Manually annotated by BRENDA team
Phelps, D.C.; Hatefi, Y.
Inhibition of the mitochondrial nicotinamide nucleotide transhydrogenase by dicyclohexylcarbodiimide and diethylpyrocarbonate
J. Biol. Chem.
256
8217-8221
1981
Bos taurus
Manually annotated by BRENDA team
Anderson, W.M.; Fisher, R.R.
The subunit structure of bovine heart mitochondrial transhydrogenase
Biochim. Biophys. Acta
635
194-199
1981
Bos taurus
Manually annotated by BRENDA team
Anderson, W.M.; Fowler, W.T.; Pennington, R.M.; Fisher, R.R.
Immunochemical characterization and purification of bovine heart mitochondrial pyridine dinucleotide transhydrogenase
J. Biol. Chem.
256
1888-1895
1981
Bos taurus
Manually annotated by BRENDA team
Blazyk, J.F.; Blazyk, J.M.; Kline, C.M.
Temperature-dependent changes in the activity and tryptic susceptibility of membrane-bound transhydrogenase
J. Biol. Chem.
256
691-694
1981
Bos taurus
Manually annotated by BRENDA team
O'Neal, S.G.; Earle, S.R.; Fisher, R.R.
The effect of metal ions on mitochondrial pyridine dinucleotide transhydrogenase
Biochim. Biophys. Acta
589
217-230
1980
Bos taurus
Manually annotated by BRENDA team
Rydström, J.; Fleischer, S.
Reconstitution of mitochondrial nicotinamide nucleotide transhydrogenase from beef heart with synthetic phospholipids
Methods Enzymol.
55
811-816
1979
Bos taurus
Manually annotated by BRENDA team
Rydström, J.
Assay of nicotinamide nucleotide transhydrogenases in mammalian, bacterial, and reconstituted systems
Methods Enzymol.
55
261-273
1979
Azotobacter sp., Bos taurus, Escherichia coli, Mammalia
Manually annotated by BRENDA team
Höjeberg, B.; Rydström, J.
Purification of mitochondrial nicotinamide nucleotide transhydrogenase from beef heart
Methods Enzymol.
55
275-283
1979
Bos taurus
Manually annotated by BRENDA team
Jacobs, E.; Fisher, R.R.
Resolution and reconstitution of Rhodospirillum rubrum pyridine dinucleotide transhydrogenase: chemical modification with N-ethylmaleimide and 2,4-pentanedione
Biochemistry
18
4315-4322
1979
Rhodospirillum rubrum
Manually annotated by BRENDA team
Hanson, R.L.
The kinetic mechanism of pyridine nucleotide transhydrogenase from Escherichia coli
J. Biol. Chem.
254
888-893
1979
Escherichia coli
Manually annotated by BRENDA team
Anderson, W.M.; Fisher, R.R.
Purification and partial characterization of bovine heart mitochondrial pyridine dinucleotide transhydrogenase
Arch. Biochem. Biophys.
187
180-190
1978
Bos taurus
Manually annotated by BRENDA team
Jacobs, E.; Heriot, K.; Fisher, R.R.
Resolution and reconstitution of Rhodospirillum rubrum pyridine dinucleotide transhydrogenase. II. Solubilization of the membrane-bound component
Arch. Microbiol.
115
151-156
1977
Rhodospirillum rubrum
Manually annotated by BRENDA team
Höjeberg, B.; Rydström, J.
Purification and molecular properties of reconstitutively active nicotinamide nucleotide transhydrogenase from beef heart mitochondria
Biochem. Biophys. Res. Commun.
78
1183-1190
1977
Bos taurus
Manually annotated by BRENDA team
Rydström, J.
Energy-linked nicotinamide nucleotide transhydrogenases
Biochim. Biophys. Acta
463
155-184
1977
Bos taurus, Escherichia coli, Rattus norvegicus, Rhodospirillum rubrum
Manually annotated by BRENDA team
O'Neal, S.G.; Fisher, R.R.
Studies on sulfhydryl group modification of mitochondrial pyridine dinucleotide transhydrogenase
J. Biol. Chem.
252
4552-4556
1977
Bos taurus
Manually annotated by BRENDA team
Houghton, R.L.; Fisher, R.R.; Sanadi, D.R.
Dependence of Escherichia coli pyridine nucleotide transhydrogenase on phospholipids and its sensitivity
Biochem. Biophys. Res. Commun.
73
751-757
1976
Escherichia coli
Manually annotated by BRENDA team
Rydström, J.; Heok, J.B.; Ericson, B.G.; Hundal, T.
Evidence for a lipid dependence of mitochondrial nicotinamide nucleotide transhydrogenase
Biochim. Biophys. Acta
430
419-425
1976
Bos taurus
Manually annotated by BRENDA team
Fisher, R.R.; Rampey, S.A.; Sadighi, A.; Fisher, K.
Resolution and reconstitution of Rhodospirillum rubrum pyridine dinucleotide transhydrogenase. Proteolytic and thermal inactivation of the membrane component
J. Biol. Chem.
250
819-825
1975
Rhodospirillum rubrum
Manually annotated by BRENDA team
Singh, A.P.; Bragg, P.D.
The pyridine-nucleotide transhydrogenase of Salmonella typhimurium
J. Gen. Microbiol.
82
237-246
1974
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Berger, T.J.; Orlando, J.A.
Purification and some properties of a protein factor required for light-dependent transhydrogenase in Rhodopseudomonas spheroides
Arch. Biochem. Biophys.
159
25-31
1973
Rhodobacter sphaeroides
Manually annotated by BRENDA team
Fisher, R.R.; Kaplan, N.O.
Studies on the mitochondrial energy-linked pyridine nucleotide transhydrogenase
Biochemistry
12
1182-1188
1973
Bos taurus
Manually annotated by BRENDA team
Asano, A.; Imai, K.; Sato, K.
Oxidative phosphorylation in Micrococcus dentrificans. II. The properties of pyridine nucleotide transhydrogenase
Biochim. Biophys. Acta
143
477-486
1967
Paracoccus denitrificans
Manually annotated by BRENDA team
Fisher, R.R.; Earle, S.R.
Membrane-bound pyridine dinucleotide transhydrogenases
The Pyridine Nucleotide Coenzymes (Everse, J. , Andersson, B. , You, K. S. , eds. ) Academic Press, New York
279-324
1982
Bos taurus, Mammalia
-
Manually annotated by BRENDA team
Rydström, J.; Persson, B.; Carlenor, E.
Transhydrogenases linked to pyridine nucleotides
Pyridine Nucleotide Coenzymes, Chem. Biochem. Med. Aspects (Dolphin, D. , Poulson, R. , Avramovic, O. , eds. ) Wiley and Sons, New York
2B
433-461
1987
Bos taurus, Mammalia
-
Manually annotated by BRENDA team
Rydström, J.
Mitochondrial nicotinamide nucleotide transhydrogenase
Mitochondria and Microsomes (Lee, C. P. , Schatz, G. , Dallner, G. eds. ) Addison-Wesley, Reading MA
317-335
1981
Bos taurus
-
Manually annotated by BRENDA team
Kaufman, B.; Kaplan, N.O.
Pyridine nucleotide transhydrogenase. VIII. Properties of the transhydrogenase reactions of an enzyme complex isolated from beef heart mitochondria
J. Biol. Chem.
236
2133-2139
1961
Bos taurus
Manually annotated by BRENDA team
Yamaguchi, M.; Hatefi, Y.
Energy-transducing nicotinamide nucleotide transhydrogenase. Nucleotide binding properties of the purified enzyme and proteolytic fragments
J. Biol. Chem.
268
17871-17877
1993
Bos taurus
Manually annotated by BRENDA team
Fristedt, U.; Rydström, J.; Persson, B.
Evidence for a nicotineamide nucleotide transhydrogenase in Klebsiella pneumoniae
Biochem. Biophys. Res. Commun.
198
928-932
1994
Escherichia coli, Klebsiella pneumoniae
Manually annotated by BRENDA team
Hu, X.; Zhang, J.W.; Persson, A.; Rydstrom, J.
Characterization of the interaction of NADH with proton pumping E. coli transhydrogenase reconstituted in the absence and in the presence of bacteriorhodopsin
Biochim. Biophys. Acta
1229
64-72
1995
Escherichia coli
Manually annotated by BRENDA team
Diggle, C.; Bizouarn, T.; Cotton, N.P.; Jackson, J.B.
Properties of the purified, recombinant, NADP(H)-binding domain III of the proton-translocating nicotinamide nucleotide transhydrogenase from Rhodospirillum rubrum
Eur. J. Biochem.
241
162-170
1996
Rhodospirillum rubrum
Manually annotated by BRENDA team
Diggle, C.; Quirk, P.G.; Bizouarnt, T.; Grimley, R.L.; Cottont, N.P.J.; Thomas, C.M.; Jackson, J.B.
Mutation of Tyr235 in the NAD(H)-binding subunit of the proton-translocating nicotinamide nucleotide transhydrogenase of Rhodospirillum rubrum affects the conformational dynamics of a mobile loop and lowers the catalytic activity of the enzyme
J. Biol. Chem.
271
10109-10115
1996
Rhodospirillum rubrum
Manually annotated by BRENDA team
Bizouarn, T.; Grimley, R.; Diggle, C.; Thomas, C.M.; Jackson, J.B.
Mutations at tyrosine-235 in the mobile loop region of domain I protein of transhydrogenase from Rhodospirillum rubrum strongly inhibit hydride transfer
Biochim. Biophys. Acta
1320
265-274
1997
Bos taurus, Rhodospirillum rubrum
Manually annotated by BRENDA team
Peake, S.J.; Venning, J.D.; Jackson, J.B.
A catalytically active complex formed from the recombinant dI protein of Rhodospirillum rubrum transhydrogenase, and the recombinant dIII protein of the human enzyme
Biochim. Biophys. Acta
1411
159-169
1999
Homo sapiens, Rhodospirillum rubrum
Manually annotated by BRENDA team
Bizouarn, T.; Fjellstrom, O.; Meuller, J.; Axelsson, M.; Bergkvist, A.; Johansson, C.; Goran Karlsson, B.; Rydstrom, J.
Proton translocating nicotinamide nucleotide transhydrogenase from E. coli. Mechanism of action deduced from its structural and catalytic properties
Biochim. Biophys. Acta
1457
211-228
2000
Bos taurus, Escherichia coli, Rhodospirillum rubrum
Manually annotated by BRENDA team
Weston, C.J.; White, S.A.; Jackson, B.
The unusual transhydrogenase of Entamoeba histolytica
FEBS Lett.
488
51-54
2001
Entamoeba histolytica
Manually annotated by BRENDA team
Jackson, J.B.; White, S.A.; Quirk, P.G.; Venning, J.D.
The alternating site, binding change mechanism for proton translocation by Transhydrogenase
Biochemistry
41
4173-4185
2002
Bos taurus, Entamoeba histolytica, Escherichia coli, Homo sapiens, Rhodospirillum rubrum
Manually annotated by BRENDA team
Sundaresan, V.; Yamaguchi, M.; Chartron, J.; Stout, C.D.
Conformational change in the NADP(H) binding domain of transhydrogenase defines four states
Biochemistry
42
12143-12153
2003
Rhodospirillum rubrum (Q2RSB4), Rhodospirillum rubrum
Manually annotated by BRENDA team
Arkblad, E.L.; Egorov, M.; Shakhparonov, M.; Romanova, L.; Polzikov, M.; Rydstrom, J.
Expression of proton-pumping nicotinamide nucleotide transhydrogenase in mouse, human brain and C. elegans
Comp. Biochem. Physiol. B
133
13-21
2002
Caenorhabditis elegans, Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Hickman, J.W.; Barber, R.D.; Skaar, E.P.; Donohue, T.J.
Link between the membrane-bound pyridine nucleotide transhydrogenase and glutathione-dependent processes in Rhodobacter sphaeroides
J. Bacteriol.
184
400-409
2002
Rhodobacter sphaeroides
Manually annotated by BRENDA team
Weston, C.J.; Venning, J.D.; Jackson, J.B.
The membrane-peripheral subunits of transhydrogenase from Entamoeba histolytica are functional only when dimerized
J. Biol. Chem.
277
26163-26170
2002
Entamoeba histolytica
Manually annotated by BRENDA team
Singh, A.; Venning, J.D.; Quirk, P.G.; van Boxel, G.I.; Rodrigues, D.J.; White, S.A.; Jackson, J.B.
Interactions between transhydrogenase and thio-nicotinamide Analogues of NAD(H) and NADP(H) underline the importance of nucleotide conformational changes in coupling to proton translocation
J. Biol. Chem.
278
33208-33216
2003
Homo sapiens (Q13423), Rhodospirillum rubrum
Manually annotated by BRENDA team
Rydstroem, J.
Mitochondrial NADPH transhydrogenase and disease
Biochim. Biophys. Acta
1757
721-726
2006
Caenorhabditis elegans, Mus musculus
Manually annotated by BRENDA team
Whitehead, S.J.; Rossington, K.E.; Hafiz, A.; Cotton, N.P.; Jackson, J.B.
Zinc ions selectively inhibit steps associated with binding and release of NADP(H) during turnover of proton-translocating transhydrogenase
FEBS Lett.
579
2863-2867
2005
Rhodospirillum rubrum
Manually annotated by BRENDA team
Arkblad, E.L.; Tuck, S.; Pestov, N.B.; Dmitriev, R.I.; Kostina, M.B.; Stenvall, J.; Tranberg, M.; Rydstroem, J.
A Caenorhabditis elegans mutant lacking functional nicotinamide nucleotide transhydrogenase displays increased sensitivity to oxidative stress
Free Radic. Biol. Med.
38
1518-1525
2005
Caenorhabditis elegans
Manually annotated by BRENDA team
Rydstroem, J.
Mitochondrial transhydrogenase - a key enzyme in insulin secretion and, potentially, diabetes
Trends Biochem. Sci.
31
355-358
2006
Mus musculus
Manually annotated by BRENDA team
Kabus, A.; Georgi, T.; Wendisch, V.F.; Bott, M.
Expression of the Escherichia coli pntAB genes encoding a membrane-bound transhydrogenase in Corynebacterium glutamicum improves L-lysine formation
Appl. Microbiol. Biotechnol.
75
47-53
2007
Escherichia coli
Manually annotated by BRENDA team
Aston-Mourney, K.; Wong, N.; Kebede, M.; Zraika, S.; Balmer, L.; McMahon, J.M.; Fam, B.C.; Favaloro, J.; Proietto, J.; Morahan, G.; Andrikopoulos, S.
Increased nicotinamide nucleotide transhydrogenase levels predispose to insulin hypersecretion in a mouse strain susceptible to diabetes
Diabetologia
50
2476-2485
2007
Mus musculus
Manually annotated by BRENDA team
Mercer-Haines, N.; Fioravanti, C.F.
Hymenolepis diminuta: mitochondrial transhydrogenase as an additional site for anaerobic phosphorylation
Exp. Parasitol.
119
24-29
2008
Hymenolepis diminuta
Manually annotated by BRENDA team
Vandock, K.P.; Smith, S.L.; Fioravanti, C.F.
Midgut mitochondrial transhydrogenase in wandering stage larvae of the tobacco hornworm, Manduca sexta
Arch. Insect Biochem. Physiol.
69
118-126
2008
Manduca sexta
Manually annotated by BRENDA team
Olgun, A.
Converting NADH to NAD+ by nicotinamide nucleotide transhydrogenase as a novel strategy against mitochondrial pathologies during aging
Biogerontology
10
531-534
2009
Caenorhabditis elegans, Macaca mulatta, Mus musculus
Manually annotated by BRENDA team
Sheeran, F.L.; Rydstroem, J.; Shakhparonov, M.I.; Pestov, N.B.; Pepe, S.
Diminished NADPH transhydrogenase activity and mitochondrial redox regulation in human failing myocardium
Biochim. Biophys. Acta
1797
1138-1148
2010
Homo sapiens, Homo sapiens (Q13423)
Manually annotated by BRENDA team
Yousuf, M.A.; Mi-ichi, F.; Nakada-Tsukui, K.; Nozaki, T.
Localization and targeting of an unusual pyridine nucleotide transhydrogenase in Entamoeba histolytica
Eukaryot. Cell
9
926-933
2010
Entamoeba histolytica (Q24858)
Manually annotated by BRENDA team
Yin, F.; Sancheti, H.; Cadenas, E.
Silencing of nicotinamide nucleotide transhydrogenase impairs cellular redox homeostasis and energy metabolism in PC12 cells
Biochim. Biophys. Acta
1817
401-409
2012
Rattus norvegicus
Manually annotated by BRENDA team
Ripoll, V.M.; Meadows, N.A.; Bangert, M.; Lee, A.W.; Kadioglu, A.; Cox, R.D.
Nicotinamide nucleotide transhydrogenase (NNT) acts as a novel modulator of macrophage inflammatory responses
FASEB J.
26
3550-3562
2012
Mus musculus, Mus musculus C3H/HeJ, Mus musculus C57/BL6J
Manually annotated by BRENDA team
Ronchi, J.A.; Figueira, T.R.; Ravagnani, F.G.; Oliveira, H.C.; Vercesi, A.E.; Castilho, R.F.
A spontaneous mutation in the nicotinamide nucleotide transhydrogenase gene of C57BL/6J mice results in mitochondrial redox abnormalities
Free Radic. Biol. Med.
63
446-456
2013
Mus musculus, Mus musculus C57/BL6J
Manually annotated by BRENDA team
Gameiro, P.A.; Laviolette, L.A.; Kelleher, J.K.; Iliopoulos, O.; Stephanopoulos, G.
Cofactor balance by nicotinamide nucleotide transhydrogenase (NNT) coordinates reductive carboxylation and glucose catabolism in the tricarboxylic acid (TCA) cycle
J. Biol. Chem.
288
12967-12977
2013
Mus musculus, Mus musculus C57/BL6J
Manually annotated by BRENDA team
Vandock, K.P.; Emerson, D.J.; McLendon, K.E.; Rassman, A.A.
Phospholipid dependence of the reversible, energy-linked, mitochondrial transhydrogenase in Manduca sexta
J. Membr. Biol.
242
89-94
2011
Manduca sexta
Manually annotated by BRENDA team
Meimaridou, E.; Kowalczyk, J.; Guasti, L.; Hughes, C.; Wagner, F.; Frommolt, P.; Nuernberg, P.; Mann, P.; Banerjee, R.; Saka, H.N.; Chapple, J.P.; King, P.J,; Clark, A.J.L.; Metherell, L.A.
Mutations in NNT encoding nicotinamide nucleotide transhydrogenase cause familial glucocorticoid deficiency
Nat. Genet.
44
740-742
2012
Homo sapiens (Q13423)
Manually annotated by BRENDA team
White, S.A.; Peake, S.J.; McSweeney, S.; Leonard, G.; Cotton, N.P.; Jackson, J.B.
The high-resolution structure of the NADP(H)-binding component (dIII) of proton-translocating transhydrogenase from human heart mitochondria
Structure
8
1-12
2000
Homo sapiens, Homo sapiens (Q13423)
Manually annotated by BRENDA team
Fujisawa, Y.; Napoli, E.; Wong, S.; Song, G.; Yamaguchi, R.; Matsui, T.; Nagasaki, K.; Ogata, T.; Giulivi, C.
Impact of a novel homozygous mutation in nicotinamide nucleotide transhydrogenase on mitochondrial DNA integrity in a case of familial glucocorticoid deficiency
BBA Clin.
3
70-78
2015
Homo sapiens (Q13423)
Manually annotated by BRENDA team
Nickel, A.G.; von Hardenberg, A.; Hohl, M.; Loeffler, J.R.; Kohlhaas, M.; Becker, J.; Reil, J.C.; Kazakov, A.; Bonnekoh, J.; Stadelmaier, M.; Puhl, S.L.; Wagner, M.; Bogeski, I.; Cortassa, S.; Kappl, R.; Pasieka, B.; Lafontaine, M.; Lancaster, C.R.; Blacker, T.S.; Hall, A.R.; Duchen, M.R.; Kaestner, L.; L, L.i.
Reversal of mitochondrial transhydrogenase causes oxidative stress in heart failure
Cell Metab.
22
472-484
2015
Mus musculus
Manually annotated by BRENDA team
Scott, R.; Van Vliet, G.; Deladoey, J.
Association of adrenal insufficiency with insulin-dependent diabetes mellitus in a patient with inactivating mutations in nicotinamide nucleotide transhydrogenase A phenocopy of the animal model
Eur. J. Endocrinol.
176
C1-C2
2017
Homo sapiens
Manually annotated by BRENDA team
Jackson, J.B.; Leung, J.H.; Stout, C.D.; Schurig-Briccio, L.A.; Gennis, R.B.
Review and Hypothesis. New insights into the reaction mechanism of transhydrogenase Swivelling the dIII component may gate the proton channel
FEBS Lett.
589
2027-2033
2015
Bos taurus, Entamoeba histolytica, Rhodospirillum rubrum, Thermus thermophilus
Manually annotated by BRENDA team
Metherell, L.A.; Guerra-Assuncao, J.A.; Sternberg, M.J.; David, A.
three-dimensional model of human nicotinamide nucleotide transhydrogenase (NNT) and sequence-structure analysis of its disease-causing variations
Hum. Mutat.
37
1074-1084
2016
Homo sapiens (Q13423)
Manually annotated by BRENDA team
Leskov, I.; Neville, A.; Shen, X.; Pardue, S.; Kevil, C.G.; Granger, D.N.; Krzywanski, D.M.
Nicotinamide nucleotide transhydrogenase activity impacts mitochondrial redox balance and the development of hypertension in mice
J. Am. Soc. Hypertens.
11
110-121
2017
Mus musculus, Mus musculus C57/BL6J
Manually annotated by BRENDA team
Gameiro, P.A.; Laviolette, L.A.; Kelleher, J.K.; Iliopoulos, O.; Stephanopoulos, G.
Cofactor balance by nicotinamide nucleotide transhydrogenase (NNT) coordinates reductive carboxylation and glucose catabolism in the tricarboxylic acid (TCA) cycle
J. Biol. Chem.
288
12967-12977
2013
Homo sapiens
Manually annotated by BRENDA team
Lopert, P.; Patel, M.
Nicotinamide nucleotide transhydrogenase (Nnt) links the substrate requirement in brain mitochondria for hydrogen peroxide removal to the thioredoxin/peroxiredoxin (Trx/Prx) system
J. Biol. Chem.
289
15611-15620
2014
Rattus norvegicus
Manually annotated by BRENDA team
Ronchi, J.A.; Francisco, A.; Passos, L.A.; Figueira, T.R.; Castilho, R.F.
The contribution of nicotinamide nucleotide transhydrogenase to peroxide detoxification is dependent on the respiratory state and counterbalanced by other sources of NADPH in liver mitochondria
J. Biol. Chem.
291
20173-20187
2016
Mus musculus
Manually annotated by BRENDA team
Yamauchi, Y.; Hirasawa, T.; Nishii, M.; Furusawa, C.; Shimizu, H.
Enhanced acetic acid and succinic acid production under microaerobic conditions by Corynebacterium glutamicum harboring Escherichia coli transhydrogenase gene pntAB
J. Gen. Appl. Microbiol.
60
112-118
2014
Escherichia coli, Escherichia coli (P07001)
Manually annotated by BRENDA team
Vandock, K.; Perregaux, E.; Consiglio, B.
Effects of 20-hydroxyecdysone on the reversible mitochondrial transhydrogenase in the tobacco hornworm, Manduca sexta
J. Insect Sci.
13
0000
2013
Manduca sexta
-
Manually annotated by BRENDA team
Weinberg-Shukron, A.; Abu-Libdeh, A.; Zhadeh, F.; Carmel, L.; Kogot-Levin, A.; Kamal, L.; Kanaan, M.; Zeligson, S.; Renbaum, P.; Levy-Lahad, E.; Zangen, D.
Combined mineralocorticoid and glucocorticoid deficiency is caused by a novel founder nicotinamide nucleotide transhydrogenase mutation that alters mitochondrial morphology and increases oxidative stress
J. Med. Genet.
52
636-641
2015
Homo sapiens
Manually annotated by BRENDA team
Kaemaeraeinen, J.; Huokko, T.; Kreula, S.; Jones, P.R.; Aro, E.M.; Kallio, P.
Pyridine nucleotide transhydrogenase PntAB is essential for optimal growth and photosynthetic integrity under low-light mixotrophic conditions in Synechocystis sp. PCC 6803
New Phytol.
214
194-204
2017
Synechocystis sp.
Manually annotated by BRENDA team