Literature summary for 1.6.1.2 extracted from

Yamaguchi, M.; Hatefi, Y.
Mitochondrial nicotinamide nucleotide transhydrogenase: inhibition by ethoxyformic anhydride, dansyl chloride, and pyridoxal phosphate (1985), Arch. Biochem. Biophys., 243, 20-27.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Dansyl chloride	0.25 mM, almost complete inactivation after 8 min, NADP+ or NADPH accelerate inhibition rate	Bos taurus
ethoxyformic anhydride	2 mM, almost complete inactivation after 6 min, NADP+ or NADPH accelerate inhibition rate	Bos taurus
pyridoxal 5'-phosphate	0.8 mM, almost complete inactivation after 5 min, 0.4 mM NADP+ or NADPH protect from inactivation, inhibition can be reversed to a considerable extent by L-lysine	Bos taurus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrial membrane	-	Bos taurus	31966	-

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	-	Bos taurus	-

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Bos taurus
NADH	-	Bos taurus
NADP+	-	Bos taurus
NADPH	-	Bos taurus

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Release 2023.1 (January 2023)