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Literature summary for 1.6.1.2 extracted from
- Diminished NADPH transhydrogenase activity and mitochondrial redox regulation in human failing myocardium (2010), Biochim. Biophys. Acta, 1797, 1138-1148.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| H2O2 | 136% increase of activity at 0.5 mM | Homo sapiens |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-Chloro-7-nitrobenzo-2-oxa-1,3-diazole | 34% residual activity at 1 mM | Homo sapiens | |
| palmitoyl CoA | specifically interferes with Nnt activity by competition with NADPH-binding, 20% residual activity at 1 mM | Homo sapiens | |
| S-nitrosoglutathione | 100% inhibition at 3 mM or higher concentration | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | inner mitochondrial membrane | Homo sapiens | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 110000 | - |
SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| NADPH + NAD+ | Homo sapiens | - |
NADP+ + NADH | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q13423 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Nnt is purified using an immunocapture bead matrix | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| myocardium | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| NADPH + 3-acetylpyridine adenine dinucleotide | - |
Homo sapiens | NADP+ + reduced 3-acetylpyridine adenine dinucleotide | - |
? | |
| NADPH + NAD+ | - |
Homo sapiens | NADP+ + NADH | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| NADPH transhydrogenase | - |
Homo sapiens |
| NNT | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | Nnt activity is reduced by 18% in the heart failure | down |
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Release 2023.1 (January 2023)
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