Literature summary for 1.6.1.2 extracted from

Bizouarn, T.; Fjellstrom, O.; Meuller, J.; Axelsson, M.; Bergkvist, A.; Johansson, C.; Goran Karlsson, B.; Rydstrom, J.
Proton translocating nicotinamide nucleotide transhydrogenase from E. coli. Mechanism of action deduced from its structural and catalytic properties (2000), Biochim. Biophys. Acta, 1457, 211-228.

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Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-
Escherichia coli	-	-	-
Rhodospirillum rubrum	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
NADPH + NAD+ = NADP+ + NADH	hypothetical mechanism	Escherichia coli	a
NADPH + NAD+ = NADP+ + NADH	hypothetical mechanism	Bos taurus	a
NADPH + NAD+ = NADP+ + NADH	hypothetical mechanism	Rhodospirillum rubrum	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NADPH + oxidized 3-acetylpyridine adenine dinucleotide	enzyme also catalyzes a rapid, so called cyclic reaction, i.e. the reduction of acetylpyridine adenine dinucleotide in the presence of either NADP+ or NADPH: the NADPH/NADP+ remain permanently bound to domain III and are alternately oxidized by acetylpyridine adenine dinucleotide and then reduced by NADH in domain I	Escherichia coli	NADP+ + reduced 3-acetylpyridine adenine dinucleotide	-	?
NADPH + oxidized 3-acetylpyridine adenine dinucleotide	enzyme also catalyzes a rapid, so called cyclic reaction, i.e. the reduction of acetylpyridine adenine dinucleotide in the presence of either NADP+ or NADPH: the NADPH/NADP+ remain permanently bound to domain III and are alternately oxidized by acetylpyridine adenine dinucleotide and then reduced by NADH in domain I	Bos taurus	NADP+ + reduced 3-acetylpyridine adenine dinucleotide	-	?
NADPH + oxidized 3-acetylpyridine adenine dinucleotide	enzyme also catalyzes a rapid, so called cyclic reaction, i.e. the reduction of acetylpyridine adenine dinucleotide in the presence of either NADP+ or NADPH: the NADPH/NADP+ remain permanently bound to domain III and are alternately oxidized by acetylpyridine adenine dinucleotide and then reduced by NADH in domain I	Rhodospirillum rubrum	NADP+ + reduced 3-acetylpyridine adenine dinucleotide	-	?

Subunits

Subunits	Comment	Organism
dimer	-	Bos taurus
tetramer	-	Escherichia coli

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Escherichia coli
NAD+	-	Bos taurus
NAD+	-	Rhodospirillum rubrum
NADH	-	Escherichia coli
NADH	-	Bos taurus
NADH	-	Rhodospirillum rubrum
NADP+	-	Escherichia coli
NADP+	-	Bos taurus
NADP+	-	Rhodospirillum rubrum
NADPH	-	Escherichia coli
NADPH	-	Bos taurus
NADPH	-	Rhodospirillum rubrum

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Release 2023.1 (January 2023)