Protein Variants | Comment | Organism |
---|---|---|
A1008P | the mutation is associated with familial glucocorticoid deficiency | Homo sapiens |
A533V | the mutation is associated with familial glucocorticoid deficiency | Homo sapiens |
G678R | the mutation is associated with familial glucocorticoid deficiency | Homo sapiens |
H365P | the mutation is associated with familial glucocorticoid deficiency | Homo sapiens |
L977P | the mutation is associated with familial glucocorticoid deficiency | Homo sapiens |
P437L | the mutation is associated with familial glucocorticoid deficiency | Homo sapiens |
S193N | the mutation is associated with familial glucocorticoid deficiency | Homo sapiens |
Y201K | the mutation is associated with familial glucocorticoid deficiency | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial membrane | - |
Homo sapiens | 31966 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NADPH + NAD+ + H+[side 1] | Homo sapiens | - |
NADP+ + NADH + H+[side 2] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q13423 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | - |
Homo sapiens | - |
NCI-H295R cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NADPH + NAD+ + H+[side 1] | - |
Homo sapiens | NADP+ + NADH + H+[side 2] | - |
? |
Synonyms | Comment | Organism |
---|---|---|
nicotinamide nucleotide transhydrogenase | - |
Homo sapiens |
NNT | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme uses energy from the mitochondrial proton gradient to produce high concentrations of NADPH | Homo sapiens |
physiological function | the enzyme plays a role in reactive oxygen species detoxification in human adrenal glands | Homo sapiens |