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Information on EC 1.2.1.88 - L-glutamate gamma-semialdehyde dehydrogenase

for references in articles please use BRENDA:EC1.2.1.88

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IUBMB Comments

This enzyme catalyses the irreversible oxidation of glutamate-γ-semialdehyde to glutamate as part of the proline degradation pathway. (S)-1-pyrroline-5-carboxylate, the product of the first enzyme of the pathway (EC 1.5.5.2, proline dehydrogenase) is in spontaneous equilibrium with its tautomer L-glutamate γ-semialdehyde. In many bacterial species, both activities are carried out by a single bifunctional enzyme [3,4].The enzyme can also oxidize other 1-pyrrolines, e.g. 3-hydroxy-1-pyrroline-5-carboxylate is converted into 4-hydroxyglutamate and (R)-1-pyrroline-5-carboxylate is converted into D-glutamate. NADP+ can also act as acceptor, but with lower activity .

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

Synonyms
p5cdh, aldh4a1, p5c dehydrogenase, 1-pyrroline-5-carboxylate dehydrogenase, p5c synthase, pyrroline-5-carboxylate dehydrogenase, gsaldh, delta1-pyrroline-5-carboxylate dehydrogenase, delta1-pyrroline-5-carboxylate synthetase, pyrroline-5-carboxylic acid dehydrogenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-glutamate 5-semialdehyde + NAD+ + H2O = L-glutamate + NADH + H+
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
ethene biosynthesis II (microbes), L-arginine degradation I (arginase pathway), L-proline degradation I