Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.2.1.88 extracted from

  • Strecker, H.J.
    The interconversion of glutamic acid and proline (1960), J. Biol. Chem., 235, 3218-3223.
No PubMed abstract available
Search for more literature for 1.2.1.88

Inhibitors

Inhibitors Comment Organism Structure
5-Aminopentanoate
-
 Bos taurus
ADP
-
 Bos taurus
AMP
-
 Bos taurus
ATP
-
 Bos taurus
CN-
-
 Bos taurus
Cu2+
-
 Bos taurus
additional information no inhibition: Ca2+, Mn2+, Mg2+, Ba2+, Pb2+, N-ethylmaleimide, o-phenanthroline Bos taurus
N-ethylmaleimide no inhibition Bos taurus
NH2OH
-
 Bos taurus
p-hydroxymercuribenzoate
-
 Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Bos taurus

Storage Stability

Storage Stability Organism
-15°C, 50% loss of activity, 2 months Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-pyrroline-5-carboxylate + NAD+ + H2O
-
 Bos taurus L-glutamate + NADH
-
 ir
DELTA1-pyrroline-3-hydroxy-5-carboxylate + NAD+ + H2O
-
 Bos taurus 4-hydroxyglutamate + NADH
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5 8.6
-
 Bos taurus

pH Range

pH Minimum pH Maximum Comment Organism
7.4 9.4
-
 Bos taurus

Cofactor

Cofactor Comment Organism Structure
NAD+ preferentially Bos taurus
NADP+
-
 Bos taurus