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Literature summary for 1.2.1.88 extracted from

  • Small, W.C.; Jones, M.E.
    Pyrroline 5-carboxylate dehydrogenase of the mitochondrial matrix of rat liver. Purification, physical and kinetic characteristics (1990), J. Biol. Chem., 265, 18668-18672.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-aminopentanoate
-
Rattus norvegicus
AMP
-
Rattus norvegicus
L-hydroxyproline
-
Rattus norvegicus
p-hydroxymercuribenzoate
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information
-
Rattus norvegicus
0.09
-
1-pyrroline-5-carboxylate
-
Rattus norvegicus
0.17
-
1-pyrroline-5-carboxylate
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion matrix Homo sapiens 5739
-
mitochondrion matrix Rattus norvegicus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
59000
-
2 * 59000, SDS-PAGE Rattus norvegicus
66000
-
66000, SDS-PAGE Homo sapiens
115000
-
sucrose-glycerol density gradient sedimentation Rattus norvegicus
142000
-
gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
27.1
-
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-pyrroline-5-carboxylate + NAD+ + H2O
-
Homo sapiens L-glutamate + NADH
-
ir
1-pyrroline-5-carboxylate + NAD+ + H2O
-
Rattus norvegicus L-glutamate + NADH
-
ir
additional information slight activity with glutaric semialdehyde and adipic semialdehyde Homo sapiens ?
-
?
additional information slight activity with glutaric semialdehyde and adipic semialdehyde Rattus norvegicus ?
-
?

Subunits

Subunits Comment Organism
dimer 2 * 59000, SDS-PAGE Rattus norvegicus
dimer 66000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
P5C dehydrogenase
-
Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8 8.5
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens
NAD+
-
Rattus norvegicus