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EC 1.14.14.152 Details
show Brenda entryEC number
1.14.14.152
Accepted name
β-amyrin 11-oxidase
Reaction
β-amyrin + 2 [reduced NADPH—hemoprotein reductase] + 2 O2 = 11-oxo-β-amyrin + 2 [oxidized NADPH—hemoprotein reductase] + 3 H2O (overall reaction);;(1a) β-amyrin + [reduced NADPH—hemoprotein reductase] + O2 = 11α-hydroxy-β-amyrin + [oxidized NADPH—hemoprotein reductase] + H2O;;(1b) 11α-hydroxy-β-amyrin + [reduced NADPH—hemoprotein reductase] + O2 = 11-oxo-β-amyrin + [oxidized NADPH—hemoprotein reductase] + 2 H2O
Other name(s)
CYP88D6
Systematic name
β-amyrin,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (hydroxylating)
Comment
A cytochrome P-450 (heme-thiolate) protein from the plant Glycyrrhiza uralensis (Chinese licorice) that participates in the glycyrrhizin biosynthesis pathway. The enzyme is also able to oxidize 30-hydroxy-β-amyrin to 11α,30-dihydroxy-β-amyrin but this is not thought to be part of glycyrrhizin biosynthesis.
History
created 2011 as EC 1.14.13.134, transferred 2018 to EC 1.14.14.152
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.6.1 created 1961, deleted 2002 1.6.6.2 created 1961, deleted 2002 1.6.6.3 created 1961, deleted 2002 1.6.6.4 created 1961, deleted 2002 1.6.6.5 created 1961, deleted 1964 1.6.6.6 created 1961, deleted 2002 1.6.6.7 created 1961, deleted 2002 1.6.6.8 created 1965, deleted 2002 1.6.6.10 created 1972, deleted 2002 1.6.6.11 created 1972, deleted 2002 1.6.6.12 created 1989, deleted 2002 1.6.6.13 created 1989, deleted 2002 1.14.14.2 created 1972, deleted 1976 1.14.14.4 created 2000, deleted 2002
