EC Explorer
[browse EC tree] - [search]
EC 1.14.14.37 Details
show Brenda entryEC number
1.14.14.37
Accepted name
4-hydroxyphenylacetaldehyde oxime monooxygenase
Reaction
(E)-4-hydroxyphenylacetaldehyde oxime + [reduced NADPH—hemoprotein reductase] + O2 = (S)-4-hydroxymandelonitrile + [oxidized NADPH—hemoprotein reductase] + 2 H2O (overall reaction);;(1a) (E)-4-hydroxyphenylacetaldehyde oxime = (Z)-4-hydroxyphenylacetaldehyde oxime;;(1b) (Z)-4-hydroxyphenylacetaldehyde oxime = 4-hydroxyphenylacetonitrile + H2O;;(1c) 4-hydroxyphenylacetonitrile + [reduced NADPH—hemoprotein reductase] + O2 = (S)-4-hydroxymandelonitrile + [oxidized NADPH—hemoprotein reductase] + H2O
Other name(s)
4-hydroxybenzeneacetaldehyde oxime monooxygenase,
cytochrome P450II-dependent monooxygenase,
NADPH-cytochrome P450 reductase (CYP71E1),
CYP71E1,
4-hydroxyphenylacetaldehyde oxime,NADPH:oxygen oxidoreductase
Systematic name
(E)-4-hydroxyphenylacetaldehyde oxime,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase
Comment
This cytochrome P-450 (heme thiolate) enzyme is involved in the biosynthesis of the cyanogenic glucoside dhurrin in sorghum. It catalyses three different activities - isomerization of the (E) isomer to the (Z) isomer, dehydration, and C-hydroxylation.
History
created 2000 as EC 1.14.13.68, modified 2005, transferred 2016 to EC 1.14.14.37
back to topEC Tree
1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.6.1 created 1961, deleted 2002 1.6.6.2 created 1961, deleted 2002 1.6.6.3 created 1961, deleted 2002 1.6.6.4 created 1961, deleted 2002 1.6.6.5 created 1961, deleted 1964 1.6.6.6 created 1961, deleted 2002 1.6.6.7 created 1961, deleted 2002 1.6.6.8 created 1965, deleted 2002 1.6.6.10 created 1972, deleted 2002 1.6.6.11 created 1972, deleted 2002 1.6.6.12 created 1989, deleted 2002 1.6.6.13 created 1989, deleted 2002 1.14.14.2 created 1972, deleted 1976 1.14.14.4 created 2000, deleted 2002
