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EC 1.14.14.41 Details
show Brenda entryEC number
1.14.14.41
Accepted name
(E)-2-methylbutanal oxime monooxygenase
Reaction
(1) (E)-2-methylbutanal oxime + [reduced NADPH—hemoprotein reductase] + O2 = 2-hydroxy-2-methylbutanenitrile + [oxidized NADPH—hemoprotein reductase] + 2 H2O (overall reaction);;(1a) (E)-2-methylbutanal oxime = (Z)-2-methylbutanal oxime;;(1b) (Z)-2-methylbutanal oxime = 2-methylbutanenitrile + H2O;;(1c) 2-methylbutanenitrile + [reduced NADPH—hemoprotein reductase] + O2 = 2-hydroxy-2-methylbutanenitrile + [oxidized NADPH—hemoprotein reductase] + H2O;;(2) (E)-2-methylpropanal oxime + [reduced NADPH—hemoprotein reductase] + O2 = 2-hydroxy-2-methylpropanenitrile + [oxidized NADPH—hemoprotein reductase] + 2 H2O (overall reaction);;(2a) (E)-2-methylpropanal oxime = (Z)-2-methylpropanal oxime;;(2b) (Z)-2-methylpropanal oxime = 2-methylpropanenitrile + H2O;;(2c) 2-methylpropanenitrile + [reduced NADPH—hemoprotein reductase] + O2 = 2-hydroxy-2-methylpropanenitrile + [oxidized NADPH—hemoprotein reductase] + H2O
Other name(s)
CYP71E7 (gene name)
Systematic name
(E)-2-methylbutanal oxime,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase
Comment
This cytochrome P-450 (heme thiolate) enzyme is involved in the biosynthesis of the cyanogenic glucosides lotaustralin and linamarin. It catalyses three different activities - isomerization of its substrate, the (E) isomer, to the (Z) isomer, dehydration, and C-hydroxylation.
History
created 2017
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.6.1 created 1961, deleted 2002 1.6.6.2 created 1961, deleted 2002 1.6.6.3 created 1961, deleted 2002 1.6.6.4 created 1961, deleted 2002 1.6.6.5 created 1961, deleted 1964 1.6.6.6 created 1961, deleted 2002 1.6.6.7 created 1961, deleted 2002 1.6.6.8 created 1965, deleted 2002 1.6.6.10 created 1972, deleted 2002 1.6.6.11 created 1972, deleted 2002 1.6.6.12 created 1989, deleted 2002 1.6.6.13 created 1989, deleted 2002 1.14.14.2 created 1972, deleted 1976 1.14.14.4 created 2000, deleted 2002
