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EC 1.14.14.22 Details
show Brenda entryEC number
1.14.14.22
Accepted name
dibenzothiophene sulfone monooxygenase
Reaction
dibenzothiophene-5,5-dioxide + FMNH2 + NADH + O2 = 2′-hydroxybiphenyl-2-sulfinate + H2O + FMN + NAD+ + H+ (overall reaction);;(1a) FMNH2 + O2 = FMN-N5-peroxide;;(1b) dibenzothiophene-5,5-dioxide + FMN-N5-peroxide = 2′-hydroxybiphenyl-2-sulfinate + FMN-N5-oxide;;(1c) FMN-N5-oxide + NADH = FMN + H2O + NAD+ + H+ (spontaneous)
Other name(s)
dszA (gene name)
Systematic name
dibenzothiophene-5,5-dioxide,FMNH2:oxygen oxidoreductase
Comment
This bacterial enzyme catalyses a step in the desulfurization pathway of dibenzothiophenes. The enzyme forms a two-component system with a dedicated NADH-dependent FMN reductase (EC 1.5.1.42) encoded by the dszD gene, which also interacts with EC 1.14.14.21, dibenzothiophene monooxygenase. The flavin-N5-oxide that is formed by the enzyme reacts spontaneously with NADH to give oxidized flavin, releasing a water molecule.
History
created 2016, modified 2019
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.6.1 created 1961, deleted 2002 1.6.6.2 created 1961, deleted 2002 1.6.6.3 created 1961, deleted 2002 1.6.6.4 created 1961, deleted 2002 1.6.6.5 created 1961, deleted 1964 1.6.6.6 created 1961, deleted 2002 1.6.6.7 created 1961, deleted 2002 1.6.6.8 created 1965, deleted 2002 1.6.6.10 created 1972, deleted 2002 1.6.6.11 created 1972, deleted 2002 1.6.6.12 created 1989, deleted 2002 1.6.6.13 created 1989, deleted 2002 1.14.14.2 created 1972, deleted 1976 1.14.14.4 created 2000, deleted 2002
