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EC 1.14.14.168 Details
show Brenda entryEC number
1.14.14.168
Accepted name
germacrene A acid 8β-hydroxylase
Reaction
germacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH—hemoprotein reductase] + O2 = 8β-hydroxygermacra-1(10),4,11(13)-trien-12-oate + [oxidized NADPH—hemoprotein reductase] + H2O
Other name(s)
HaG8H,
CYP71BL1,
CYP71BL6
Systematic name
germacra-1(10),4,11(13)-trien-12-oate,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (8β-hydroxylating)
Comment
A cytochrome P-450 (heme-thiolate) protein from the plant Helianthus annuus (common sunflower). The cyclisation of 8β-hydroxygermacra-1(10),4,11(13)-triene-12-oate to inunolide (12,8β) does not seem to occur spontaneously. The enzyme from Inula hupehensis also forms some 8α-hydroxygermacra-1(10),4,11(13)-triene-12-oate, which spontaneously cyclises to 8-epi-inunolide (12,8α) (cf. EC 1.14.14.170 8-epi-inunolide synthase).
History
created 2018
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.6.1 created 1961, deleted 2002 1.6.6.2 created 1961, deleted 2002 1.6.6.3 created 1961, deleted 2002 1.6.6.4 created 1961, deleted 2002 1.6.6.5 created 1961, deleted 1964 1.6.6.6 created 1961, deleted 2002 1.6.6.7 created 1961, deleted 2002 1.6.6.8 created 1965, deleted 2002 1.6.6.10 created 1972, deleted 2002 1.6.6.11 created 1972, deleted 2002 1.6.6.12 created 1989, deleted 2002 1.6.6.13 created 1989, deleted 2002 1.14.14.2 created 1972, deleted 1976 1.14.14.4 created 2000, deleted 2002
