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7.6.2.8: ABC-type vitamin B12 transporter

This is an abbreviated version!
For detailed information about ABC-type vitamin B12 transporter, go to the full flat file.

Word Map on EC 7.6.2.8

Reaction

ATP
+
H2O
 +
vitamin B12-[cobalamin-binding protein][side 1]
=
ADP
 +
phosphate
 +
vitamin B12[side 2]
 +
[cobalamin-binding protein][side 1]

Synonyms

ABC transporter, ABCD4, BtuC, BtuCD, BtuCD vitamin B12 importer, BtuCD-BtuF, BtuCD-F, BtuCD-F complex, BtuD, BtuF, BtuF-CD, BtuM, BtuMTd, Cbl transporter, cobalamin-specific ECF-type ABC transporter, EC 3.6.3.33, ECF-CbrT, ECF-type ABC transporter for vitamin B12, energy coupling factor (ECF-) type ABC transporter, Rv1819c, Tbd_2719, vitamin B12 ABC importer, vitamin B12 import ATP-binding protein, vitamin B12 import system, vitamin B12 import system permease protein, vitamin B12 importer, vitamin B12 transporter, vitamin B12-binding protein, vitamin B12-transporting ATPase

ECTree

     7 Translocases
         7.6 Catalysing the translocation of other compounds
             7.6.2 Linked to the hydrolysis of a nucleoside triphosphate
                7.6.2.8 ABC-type vitamin B12 transporter

Reference

topprint

Reference on EC 7.6.2.8 - ABC-type vitamin B12 transporter

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Friedrich, M.J.; DeVaux, L.C.; Kadner,R.
Nucleotide sequence of the btuCED genes involved in vitamin B12 transport in Escherichia coli and homology with components of periplasmic-binding-protein-dependent transport systems
J. Bacteriol.
167
928-934
1986
Escherichia coli
Manually annotated by BRENDA team
Kadner, R.J.
Vitamin B12 transport in Escherichia coli: energy coupling between membranes
Mol. Microbiol.
12
2027-2033
1990
Escherichia coli
Manually annotated by BRENDA team
Rioux, C.R.; Kadner, R.J.
Vitamin B12 transport in Escherichia coli K12 does not require the btuE gene of the Btu CED operon
Mol. Gen. Genet.
217
301-308
1989
Escherichia coli
Manually annotated by BRENDA team
De Vaux, L.C.; Clevenson, D.S.; Bradbeer, C.; Kadner, R.J.
Identification of the btuCED polypeptides and evidence for their role in vitamin B12 transport in Escherichia coli
J. Bacteriol.
167
920-927
1986
Escherichia coli
Manually annotated by BRENDA team
De Vaux, L.C.; Kadner, R.
Transport of vitamin B12 in Escherichia coli: Cloning of the btuCD region
J. Bacteriol.
162
888-896
1985
Escherichia coli
Manually annotated by BRENDA team
Rioux, C.R.; Kadner, R.J.
Two outer membrane transport systems for vitamin B12 in Salmonella typhimurium
J. Bacteriol.
171
2986-2993
1989
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Borths, E.L.; Poolman, B.; Hvorup, R.N.; Locher, K.P.; Rees, D.C.
In vitro functional characterization of BtuCD-F, the Escherichia coli ABC transporter for vitamin B12 uptake
Biochemistry
44
16301-16309
2005
Escherichia coli
Manually annotated by BRENDA team
Kandt, C.; Xu, Z.; Tieleman, D.P.
Opening and closing motions in the periplasmic vitamin B12 binding protein BtuF
Biochemistry
45
13284-13292
2006
Escherichia coli (P06611), Escherichia coli
Manually annotated by BRENDA team
Ivetac, A.; Campbell, J.D.; Sansom, M.S.
Dynamics and function in a bacterial ABC transporter: simulation studies of the BtuCDF system and its components
Biochemistry
46
2767-2778
2007
Escherichia coli (P06611)
Manually annotated by BRENDA team
Liu, M.; Sun, T.; Hu, J.; Chen, W.; Wang, C.
Study on the mechanism of the BtuF periplasmic-binding protein for vitamin B(12)
Biophys. Chem.
135
19-24
2008
Escherichia coli (P37028)
Manually annotated by BRENDA team
Sonne, J.; Kandt, C.; Peters, G.H.; Hansen, F.Y.; Jensen, M.?.; Tieleman, D.P.
Simulation of the coupling between nucleotide binding and transmembrane domains in the ATP binding cassette transporter BtuCD
Biophys. J.
92
2727-2734
2007
Escherichia coli (P37028)
Manually annotated by BRENDA team
Weng, J.; Ma, J.; Fan, K.; Wang, W.
The conformational coupling and translocation mechanism of vitamin B12 ATP-binding cassette transporter BtuCD
Biophys. J.
94
612-621
2008
Escherichia coli (P06611), Escherichia coli
Manually annotated by BRENDA team
Hvorup, R.N.; Goetz, B.A.; Niederer, M.; Hollenstein, K.; Perozo, E.; Locher, K.P.
Asymmetry in the structure of the ABC transporter-binding protein complex BtuCD-BtuF
Science
317
1387-1390
2007
Escherichia coli (P06611), Escherichia coli
Manually annotated by BRENDA team
Weng, J.; Ma, J.; Fan, K.; Wang, W.
Asymmetric conformational flexibility in the ATP-binding cassette transporter HI1470/1
Biophys. J.
96
1918-1930
2009
Haemophilus influenzae
Manually annotated by BRENDA team
Goetz, B.A.; Perozo, E.; Locher, K.P.
Distinct gate conformations of the ABC transporter BtuCD revealed by electron spin resonance spectroscopy and chemical cross-linking
FEBS Lett.
583
266-270
2009
Escherichia coli (P06611), Escherichia coli
Manually annotated by BRENDA team
Lewinson, O.; Lee, A.T.; Locher, K.P.; Rees, D.C.
A distinct mechanism for the ABC transporter BtuCD-BtuF revealed by the dynamics of complex formation
Nat. Struct. Mol. Biol.
17
332-338
2010
Escherichia coli
Manually annotated by BRENDA team
Kandt, C.; Tieleman, D.P.
Holo-BtuF stabilizes the open conformation of the vitamin B12 ABC transporter BtuCD
Proteins
78
738-753
2010
Escherichia coli
Manually annotated by BRENDA team
Sun, T.; Liu, M.; Chen, W.; Wang, C.
Molecular dynamics simulation of the transmembrane subunit of BtuCD in the lipid bilayer
Sci. China C Life Sci.
53
620-630
2010
Escherichia coli
Manually annotated by BRENDA team
Korkhov, V.M.; Mireku, S.A.; Hvorup, R.N.; Locher, K.P.
Asymmetric states of vitamin B12 transporter BtuCD are not discriminated by its cognate substrate binding protein BtuF
FEBS Lett.
586
972-976
2012
Escherichia coli
Manually annotated by BRENDA team
Di Bartolo, N.D.; Hvorup, R.N.; Locher, K.P.; Booth, P.J.
In vitro folding and assembly of the Escherichia coli ATP-binding cassette transporter, BtuCD
J. Biol. Chem.
286
18807-18815
2011
Escherichia coli
Manually annotated by BRENDA team
Joseph, B.; Jeschke, G.; Goetz, B.A.; Locher, K.P.; Bordignon, E.
Transmembrane gate movements in the type II ATP-binding cassette (ABC) importer BtuCD-F during nucleotide cycle
J. Biol. Chem.
286
41008-41017
2011
Escherichia coli (P06609), Escherichia coli
Manually annotated by BRENDA team
Weng, J.; Fan, K.; Wang, W.
The conformational transition pathways of ATP-binding cassette transporter BtuCD revealed by targeted molecular dynamics simulation
PLoS ONE
7
e305465
2012
Escherichia coli (P06611)
-
Manually annotated by BRENDA team
Su, J.G.; Zhang, X.; Zhao, S.X.; Li, X.Y.; Hou, Y.X.; Wu, Y.D.; Zhu, J.Z.; An, H.L.
Conformational motions and functionally key residues for vitamin B12 transporter BtuCD-BtuF revealed by elastic network model with a function-related internal coordinate
Int. J. Mol. Sci.
16
17933-17951
2015
Escherichia coli (P37028), Escherichia coli
Manually annotated by BRENDA team
Joseph, B.; Korkhov, V.M.; Yulikov, M.; Jeschke, G.; Bordignon, E.
Conformational cycle of the vitamin B12 ABC importer in liposomes detected by double electron-electron resonance (DEER)
J. Biol. Chem.
289
3176-3185
2014
Escherichia coli
Manually annotated by BRENDA team
Korkhov, V.M.; Mireku, S.A.; Veprintsev, D.B.; Locher, K.P.
Structure of AMP-PNP-bound BtuCD and mechanism of ATP-powered vitamin B12 transport by BtuCD-F
Nat. Struct. Mol. Biol.
21
1097-1099
2014
Escherichia coli (P06609), Escherichia coli
Manually annotated by BRENDA team
Korkhov, V.M.; Mireku, S.A.; Locher, K.P.
Structure of AMP-PNP-bound vitamin B12 transporter BtuCD-F
Nature
490
367-372
2012
Escherichia coli (P06609), Escherichia coli
Manually annotated by BRENDA team
Gopinath, K.; Venclovas, A.; Ioerger, T.; Sacchettini, J.; McKinney, J.; Mizrahi, V.; Warner, D.
A vitamin B12 transporter in Mycobacterium tuberculosis
Open Biology
3
120175
2013
Mycobacterium tuberculosis
Manually annotated by BRENDA team
Okamoto, T.; Kawaguchi, K.; Watanabe, S.; Agustina, R.; Ikejima, T.; Ikeda, K.; Nakano, M.; Morita, M.; Imanaka, T.
Characterization of human ATP-binding cassette protein subfamily D reconstituted into proteoliposomes
Biochem. Biophys. Res. Commun.
496
1122-1127
2018
Homo sapiens (O14678), Homo sapiens
Manually annotated by BRENDA team
Agarwal, S.; Dey, S.; Ghosh, B.; Biswas, M.; Dasgupta, J.
Mechanistic basis of vitamin B12 and cobinamide salvaging by the Vibrio species
Biochim. Biophys. Acta
1867
140-151
2019
Vibrio cholerae serotype O1 (A0A0H3AMA6 AND A5F1V0 AND A5F5P5), Vibrio cholerae serotype O1 Classical Ogawa 395 (A0A0H3AMA6 AND A5F1V0 AND A5F5P5), Vibrio cholerae serotype O1 ATCC 39541 (A0A0H3AMA6 AND A5F1V0 AND A5F5P5), Vibrio cholerae serotype O1 O395 (A0A0H3AMA6 AND A5F1V0 AND A5F5P5)
Manually annotated by BRENDA team
Priess, M.; Schaefer, L.V.
Release of entropic spring reveals conformational coupling mechanism in the ABC transporter BtuCD-F
Biophys. J.
110
2407-2418
2016
Escherichia coli (P06609 AND P06611 AND P37028), Escherichia coli
Manually annotated by BRENDA team
Santos, J.A.; Rempel, S.; Mous, S.T.; Pereira, C.T.; Ter Beek, J.; de Gier, J.W.; Guskov, A.; Slotboom, D.J.
Functional and structural characterization of an ECF-type ABC transporter for vitamin B12
eLife
7
e35828
2018
Lactobacillus delbrueckii subsp. bulgaricus (Q1GBI8), Lactobacillus delbrueckii subsp. bulgaricus DSM 20081 (Q1GBI8), Lactobacillus delbrueckii subsp. bulgaricus NBRC 13953 (Q1GBI8), Lactobacillus delbrueckii subsp. bulgaricus JCM 1002 (Q1GBI8), Lactobacillus delbrueckii subsp. bulgaricus NCIMB 11778 (Q1GBI8), Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842 (Q1GBI8)
Manually annotated by BRENDA team
Schmitt, L.
Vitamin B12 import is all about timing
Nat. Chem. Biol.
14
640-641
2018
Escherichia coli (P06609 AND P06611 AND P37028)
Manually annotated by BRENDA team
Goudsmits, J.M.H.; Slotboom, D.J.; van Oijen, A.M.
Single-molecule visualization of conformational changes and substrate transport in the vitamin B12 ABC importer BtuCD-F
Nat. Commun.
8
1652
2017
Escherichia coli (P06609 AND P06611 AND P37028)
Manually annotated by BRENDA team
Rempel, S.; Colucci, E.; de Gier, J.W.; Guskov, A.; Slotboom, D.J.
Cysteine-mediated decyanation of vitamin B12 by the predicted membrane transporter BtuM
Nat. Commun.
9
3038
2018
Thiobacillus denitrificans (Q3SFD8)
Manually annotated by BRENDA team
Pan, C.; Weng, J.; Wang, W.
ATP hydrolysis induced conformational changes in the vitamin B12 transporter BtuCD revealed by MD simulations
PLoS ONE
11
e0166980
2016
Escherichia coli (P06609 AND P06611 AND P37028)
Manually annotated by BRENDA team
Kawaguchi, K.; Okamoto, T.; Morita, M.; Imanaka, T.
Translocation of the ABC transporter ABCD4 from the endoplasmic reticulum to lysosomes requires the escort protein LMBD1
Sci. Rep.
6
30183
2016
Homo sapiens (O14678)
Manually annotated by BRENDA team
Mireku, S.A.; Sauer, M.M.; Glockshuber, R.; Locher, K.P.
Structural basis of nanobody-mediated blocking of BtuF, the cognate substrate-binding protein of the Escherichia coli vitamin B12 transporter BtuCD
Sci. Rep.
7
14296
2017
Escherichia coli (P06609 AND P06611 AND P37028), Escherichia coli
Manually annotated by BRENDA team
Mireku, S.A.; Ruetz, M.; Zhou, T.; Korkhov, V.M.; Kraeutler, B.; Locher, K.P.
Conformational change of a tryptophan residue in BtuF facilitates binding and transport of cobinamide by the vitamin B12 transporter BtuCD-F
Sci. Rep.
7
41575
2017
Escherichia coli (P06609 AND P06611 AND P37028), Escherichia coli
Manually annotated by BRENDA team