7.6.2.8: ABC-type vitamin B12 transporter

This is an abbreviated version!
For detailed information about ABC-type vitamin B12 transporter, go to the full flat file.

Reaction

Synonyms

ABC transporter, ABCD4, BtuC, BtuCD, BtuCD vitamin B12 importer, BtuCD-BtuF, BtuCD-F, BtuCD-F complex, BtuD, BtuF, BtuF-CD, BtuM, BtuMTd, Cbl transporter, cobalamin-specific ECF-type ABC transporter, EC 3.6.3.33, ECF-CbrT, ECF-type ABC transporter for vitamin B12, energy coupling factor (ECF-) type ABC transporter, Rv1819c, Tbd_2719, vitamin B12 ABC importer, vitamin B12 import ATP-binding protein, vitamin B12 import system, vitamin B12 import system permease protein, vitamin B12 importer, vitamin B12 transporter, vitamin B12-binding protein, vitamin B12-transporting ATPase

ECTree

     7 Translocases

         7.6 Catalysing the translocation of other compounds

             7.6.2 Linked to the hydrolysis of a nucleoside triphosphate

                7.6.2.8 ABC-type vitamin B12 transporter

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Results	in table
1	Activating Compound
2718	AA Sequence
1	CAS Registry Number
21	Cloned(Commentary)
12	Cofactor
14	Crystallization (Commentary)
33	Disease/ Diagnostics
38	General Information
2	General Stability
12	Inhibitors
1	Ki Value [mM]
3	KM Value [mM]
41	Localization
11	Metals/Ions
9	Molecular Weight [Da]
63	Natural Substrates/ Products (Substrates)
46	Organism
7	pH Optimum
23	Protein Variants
9	Purification (Commentary)
4	Reaction
2	Reaction Type
46	Reference
4	Renatured (Commentary)
11	Specific Activity [micromol/min/mg]
87	Substrates and Products (Substrate)
26	Subunits
83	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
2	Turnover Number [1/s]

Disease

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Disease on EC 7.6.2.8 - ABC-type vitamin B12 transporter

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Adrenoleukodystrophy

Decreased expression of ABCD4 and BG1 genes early in the pathogenesis of X-linked adrenoleukodystrophy.

15800013

Adrenoleukodystrophy

Identification of novel SNPs of ABCD1, ABCD2, ABCD3, and ABCD4 genes in patients with X-linked adrenoleukodystrophy (ALD) based on comprehensive resequencing and association studies with ALD phenotypes.

20661612

Anemia

Loss of abcd4 in zebrafish leads to vitamin B12-deficiency anemia.

31113616

Carcinogenesis

Novel insights into transcriptional dysregulation in colorectal cancer.

29788743

Carcinoma, Hepatocellular

Isolation and characterization of a novel vitamin B12-binding protein associated with hepatocellular carcinoma.

171283

Carcinoma, Hepatocellular

[Hepatoma with increased vitamin B12-binding protein in serum and complicated by some benign tumours: report of unusual case with autopsy findings (author's transl)]

231075

Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Electrophoretic studies of the vitamin B12-binding protein of normal and chronic myelogenous leukemia serum.

14422457

Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Identification of the vitamin B12-binding protein in the serum of normals and of patients with chronic myelocytic leukemia.

13560572

Leukocytosis

Characterization of R-type vitamin B12-binding proteins by isoelectric focusing. III. Cobalophilin (R protein) in myeloproliferative states and leukocytosis.

1056618

Muscle Hypotonia

Clinical or ATPase domain mutations in ABCD4 disrupt the interaction between the vitamin B12-trafficking proteins ABCD4 and LMBD1.

28572511

Neoplasms

[Hepatoma with increased vitamin B12-binding protein in serum and complicated by some benign tumours: report of unusual case with autopsy findings (author's transl)]

231075

Subacute Combined Degeneration

Subacute combined degeneration with high serum vitamin B12 level and abnormal vitamin B12 binding protein. New cause of an old syndrome.

8323478

Tuberculosis

A vitamin B12 transporter in Mycobacterium tuberculosis.

23407640

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