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7.6.2.8: ABC-type vitamin B12 transporter

This is an abbreviated version!
For detailed information about ABC-type vitamin B12 transporter, go to the full flat file.

Word Map on EC 7.6.2.8

Reaction

ATP
+
H2O
+
vitamin B12-[cobalamin-binding protein][side 1]
=
ADP
+
phosphate
+
vitamin B12[side 2]
+
[cobalamin-binding protein][side 1]

Synonyms

ABC transporter, ABCD4, BtuC, BtuCD, BtuCD vitamin B12 importer, BtuCD-BtuF, BtuCD-F, BtuCD-F complex, BtuD, BtuF, BtuF-CD, BtuM, BtuMTd, Cbl transporter, cobalamin-specific ECF-type ABC transporter, EC 3.6.3.33, ECF-CbrT, ECF-type ABC transporter for vitamin B12, energy coupling factor (ECF-) type ABC transporter, Rv1819c, Tbd_2719, vitamin B12 ABC importer, vitamin B12 import ATP-binding protein, vitamin B12 import system, vitamin B12 import system permease protein, vitamin B12 importer, vitamin B12 transporter, vitamin B12-binding protein, vitamin B12-transporting ATPase

ECTree

     7 Translocases
         7.6 Catalysing the translocation of other compounds
             7.6.2 Linked to the hydrolysis of a nucleoside triphosphate
                7.6.2.8 ABC-type vitamin B12 transporter

Inhibitors

Inhibitors on EC 7.6.2.8 - ABC-type vitamin B12 transporter

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
adenosyl-cobalamin
is less effective causing about 25% inhibition of cobalmin uptake
AlF3
inhibition of the ATPase activity of liposome-reconstituted His-hABCD4
cobinamide
addition of a 250fold excess of cobalamin decreases the uptake of radiolabeled cobalamin to about 25%
cyano-cobalamin
a 250fold excess of unlabeled CN-Cbl inhibits the uptake of the radiolabeled substrate almost completely
hydroxycobalamin
inhibits uptake to a similar extent as cyano-cobalamin
methylcobalamin
inhibits uptake to a similar extent as cyano-cobalamin
periplasmic binding protein BtuF
-
4fold decrease of activity in n-alkyl-phosphocholine
-
sodium ortho-vanadate
-
-
sodium orthovanadate
-
2 mM, the ATPase activity of BtuCD complex and of subunit BtuD is reduced by 96%
additional information
-