7.6.2.8: ABC-type vitamin B12 transporter
This is an abbreviated version!
For detailed information about ABC-type vitamin B12 transporter, go to the full flat file.
Word Map on EC 7.6.2.8
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7.6.2.8
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transcobalamin
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azurophilic
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cyanocobalamin
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lmbrd1
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outward-facing
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cobinamide
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inward-facing
- 7.6.2.8
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transcobalamin
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azurophilic
- cyanocobalamin
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lmbrd1
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outward-facing
- cobinamide
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inward-facing
Reaction
Synonyms
ABC transporter, ABCD4, BtuC, BtuCD, BtuCD vitamin B12 importer, BtuCD-BtuF, BtuCD-F, BtuCD-F complex, BtuD, BtuF, BtuF-CD, BtuM, BtuMTd, Cbl transporter, cobalamin-specific ECF-type ABC transporter, EC 3.6.3.33, ECF-CbrT, ECF-type ABC transporter for vitamin B12, energy coupling factor (ECF-) type ABC transporter, Rv1819c, Tbd_2719, vitamin B12 ABC importer, vitamin B12 import ATP-binding protein, vitamin B12 import system, vitamin B12 import system permease protein, vitamin B12 importer, vitamin B12 transporter, vitamin B12-binding protein, vitamin B12-transporting ATPase
ECTree
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Localization
Localization on EC 7.6.2.8 - ABC-type vitamin B12 transporter
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translocation of the ABC transporter ABCD4 from the endoplasmic reticulum to lysosomes requires the escort protein LMBD1
additional information
ABCD4 dimer makes a complex with lysosomal membrane protein LMBD1, an adopter protein, and targets to lysosome
translocation of the ABC transporter ABCD4 from the endoplasmic reticulum to lysosomes requires the escort protein LMBD1
ABCD4 barely interacts with the peroxisomal biogenesis factor Pex19p, because of its lack of NH2-terminal hydrophobic motif. As a result, the transmembrane domain (TMD) 1 of ABCD4 is recognized by certain signal recognition particles and integrated into the ER membrane. ABCD4 dimer then makes a complex with lysosomal membrane protein LMBD1, an adopter protein, and targets to lysosome
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additional information
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ABCD4 barely interacts with the peroxisomal biogenesis factor Pex19p, because of its lack of NH2-terminal hydrophobic motif. As a result, the transmembrane domain (TMD) 1 of ABCD4 is recognized by certain signal recognition particles and integrated into the ER membrane. ABCD4 dimer then makes a complex with lysosomal membrane protein LMBD1, an adopter protein, and targets to lysosome
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additional information
LMBD1 associates with ABCD4 at the ER membrane and transports ABCD4 to lysosomes, ABCD4 interacts with LMBD1. The translocation depends on the lysosomal targeting ability of LMBD1. Endogenous ABCD4 is localized to both lysosomes and the endoplasmic reticulum. ABCD4 lacks the NH2-teminal hydrophobic region that is responsible for the targeting to peroxisomes. ABCD4 and LMBD1 form complex in vitro. The regions around transmembrane helix 2 and 5 of ABCD4 are critically important for the translocation of ABCD4 to lysosomes along with LMBD1
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