5.1.3.8: N-acylglucosamine 2-epimerase
This is an abbreviated version!
For detailed information about N-acylglucosamine 2-epimerase, go to the full flat file.
Word Map on EC 5.1.3.8
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5.1.3.8
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n-acetylneuraminic
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neu5ac
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n-acetyl-d-neuraminic
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anabaena
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mannac
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takahashi
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n-acetyl-d-mannosamine
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renbp
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nal
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n-acetylmannosamine
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synthesis
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biotechnology
- 5.1.3.8
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n-acetylneuraminic
- neu5ac
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n-acetyl-d-neuraminic
- anabaena
- mannac
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takahashi
- n-acetyl-d-mannosamine
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renbp
- nal
- n-acetylmannosamine
- synthesis
- biotechnology
Reaction
Synonyms
Acylglucosamine 2-epimerase, AGE, AGE2, anAGE, AvaAGE, bage, bGlcNAc 2-epimerase, Epimerase, acylglucosamine 2-, GlcNAc 2-epimerase, GlcNAc-2-epimerase, N-acetyl-D-glucosamine 2-epimerase, N-acetyl-D-glucosamine-2-epimerase, N-Acetylglucosamine 2-epimerase, N-acyl-D-glucosamine 2-epimerase, N-acylglucosamine 2-epimerase, PhGn2E, renin binding protein, Renin-binding protein, RNBP
ECTree
5.1.3.8 N-acylglucosamine 2-epimeraseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 5.1.3.8 - N-acylglucosamine 2-epimerase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
N-acetyl-D-glucosamine
N-acetyl-D-mannosamine
Pedobacter heparinus ATCC 13125 / DSM 2366 / CIP 104194 / JCM 7457 / NBRC 12017 / NCIMB 9290 / NRRL B-14731 / HIM 762-3
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r
N-acetyl-D-mannosamine
N-acetyl-D-glucosamine
activity of isozyme AGE2, catalytic efficiency for ManNAc synthesis of the isozyme is higher than that for GlcNAc synthesis, coupled assay with N-acyl-D-mannosamine dehydrogenase, EC 1.1.1.233
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r
N-acetyl-D-mannosamine
N-acetyl-D-glucosamine
activity of isozyme AGE2, catalytic efficiency for ManNAc synthesis of the isozyme is higher than that for GlcNAc synthesis, coupled assay with N-acyl-D-mannosamine dehydrogenase, EC 1.1.1.233
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r
N-acetyl-D-mannosamine
N-acetyl-D-glucosamine
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the enzyme can serve a catabolic role, diverting metabolic flux from the sialic acid pathway
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?
N-Acyl-D-glucosamine
N-Acyl-D-mannosamine
Pedobacter heparinus ATCC 13125 / DSM 2366 / CIP 104194 / JCM 7457 / NBRC 12017 / NCIMB 9290 / NRRL B-14731 / HIM 762-3
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r
N-Acyl-D-glucosamine
N-Acyl-D-mannosamine
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also catalyzes epimerization of the corresponding N-glycolyl derivatives
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?
additional information
?
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no activity with mannosamine, glucosamine, mannose, glucose and N-acetyl-galactosamine
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?
additional information
?
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the enzyme inhibits porcine renin activity through formation of a complex of porcine renin with the recombinant enzyme, the so-called high-molecular-weight renin
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?
additional information
?
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regulatory enzyme in sialic acid biosynthesis in liver
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?
additional information
?
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N-acylglucosamine 2-epimerase is involved in sialic acid metabolism
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?
additional information
?
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regulatory enzyme in sialic acid biosynthesis in liver
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?
additional information
?
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involved in biosynthesis of N-acetylneuraminic acid
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?
additional information
?
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involved in biosynthesis of N-acetylneuraminic acid
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?
additional information
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two-step enzymatic synthesis of N-acetylneuraminic acid (Neu5Ac) using an N-acyl-d-glucosamine 2-epimerase from Anabaena variabilis ATCC 29413 (AvaAGE)in combination with an N-acetylneuraminate lyase (NAL) expressed from Escherichia coli
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?
