5.1.3.8: N-acylglucosamine 2-epimerase
This is an abbreviated version!
For detailed information about N-acylglucosamine 2-epimerase, go to the full flat file.
Word Map on EC 5.1.3.8
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5.1.3.8
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n-acetylneuraminic
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neu5ac
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n-acetyl-d-neuraminic
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anabaena
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mannac
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takahashi
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n-acetyl-d-mannosamine
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renbp
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nal
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n-acetylmannosamine
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synthesis
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biotechnology
- 5.1.3.8
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n-acetylneuraminic
- neu5ac
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n-acetyl-d-neuraminic
- anabaena
- mannac
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takahashi
- n-acetyl-d-mannosamine
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renbp
- nal
- n-acetylmannosamine
- synthesis
- biotechnology
Reaction
Synonyms
Acylglucosamine 2-epimerase, AGE, AGE2, anAGE, AvaAGE, bage, bGlcNAc 2-epimerase, Epimerase, acylglucosamine 2-, GlcNAc 2-epimerase, GlcNAc-2-epimerase, N-acetyl-D-glucosamine 2-epimerase, N-acetyl-D-glucosamine-2-epimerase, N-Acetylglucosamine 2-epimerase, N-acyl-D-glucosamine 2-epimerase, N-acylglucosamine 2-epimerase, PhGn2E, renin binding protein, Renin-binding protein, RNBP
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General Information
General Information on EC 5.1.3.8 - N-acylglucosamine 2-epimerase
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evolution
metabolism
the biosynthesis of N-acetyl-D-mannosamine can be regulated in amammals in two different ways. In the liver, UDP-GlcNAc is epimerized to UDP-ManNAc by the bifunctional UDP-GlcNAc 2-epimerase, while in the kidney (mostly), GlcNAc is directly epimerized to ManNac by GlyNAc 2-epimerase
physiological function
N-acyl-D-glucosamine 2-epimerase (AGE) is an important enzyme for the biocatalytic synthesis of N-acetylneuraminic acid (Neu5Ac)
additional information
AGE enzymes can be divided in 3 different groups,overview
evolution
mammalian enzyme requires the presence of nucleotide activators and cofactors, while the bacterial enzyme are activated by nucleotide binding, but do not require them as cofactors
evolution
mammalian enzyme requires the presence of nucleotide activators and cofactors, while the bacterial enzyme are activated by nucleotide binding, but do not require them as cofactors
evolution
Pedobacter heparinus ATCC 13125 / DSM 2366 / CIP 104194 / JCM 7457 / NBRC 12017 / NCIMB 9290 / NRRL B-14731 / HIM 762-3
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mammalian enzyme requires the presence of nucleotide activators and cofactors, while the bacterial enzyme are activated by nucleotide binding, but do not require them as cofactors
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evolution
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AGE enzymes can be divided in 3 different groups,overview
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three-dimensional structure modeling, overview
additional information
the majority of biocatalytic approaches for Neu5Ac synthesis involve an N-acylglucosamine 2-epimerase (AGE, EC 5.3.1.8) in combination with an N-acetylneuraminate lyase (NAL, EC 4.1.3.3)
additional information
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three-dimensional structure modeling, overview
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