EC Number |
General Information |
Reference |
---|
5.1.3.8 | evolution |
AGE enzymes can be divided in 3 different groups,overview |
-, 727105 |
5.1.3.8 | evolution |
mammalian enzyme requires the presence of nucleotide activators and cofactors, while the bacterial enzyme are activated by nucleotide binding, but do not require them as cofactors |
-, 747472 |
5.1.3.8 | metabolism |
the biosynthesis of N-acetyl-D-mannosamine can be regulated in amammals in two different ways. In the liver, UDP-GlcNAc is epimerized to UDP-ManNAc by the bifunctional UDP-GlcNAc 2-epimerase, while in the kidney (mostly), GlcNAc is directly epimerized to ManNac by GlyNAc 2-epimerase |
747472 |
5.1.3.8 | more |
the majority of biocatalytic approaches for Neu5Ac synthesis involve an N-acylglucosamine 2-epimerase (AGE, EC 5.3.1.8) in combination with an N-acetylneuraminate lyase (NAL, EC 4.1.3.3) |
749219 |
5.1.3.8 | more |
three-dimensional structure modeling, overview |
-, 727105 |
5.1.3.8 | physiological function |
N-acyl-D-glucosamine 2-epimerase (AGE) is an important enzyme for the biocatalytic synthesis of N-acetylneuraminic acid (Neu5Ac) |
749219 |