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3.4.24.74: fragilysin

This is an abbreviated version!
For detailed information about fragilysin, go to the full flat file.

Word Map on EC 3.4.24.74

Reaction

Broad proteolytic specificity, bonds hydrolysed including -Gly-/-Leu-, -Met-/-Leu-, -Phe-/-Leu-, -Cys-/-Leu-, Leu-/-Gly =

Synonyms

B. fragilis enterotoxin, Baceroides fragilis enterotoxin, Bacillus fragilis toxin, Bacteroides fragilis enterotoxin, Bacteroides fragilis enterotoxin-2, Bacteroides fragilis toxin, BFT, BFT-1, BFT-2, BFT-3, BFT2, Enterotoxin, FRA3, fragilysin-2, fragilysin-3, Korea-BFT, More, toxin-2

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.74 fragilysin

Inhibitors

Inhibitors on EC 3.4.24.74 - fragilysin

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
-
-
2,2'-dipyridyl
-
-
5,7-dihydroxy-3',4',6-trimethoxyflavone
-
inhibits the BFT induced nuclear factor-kappaB activation, interleukin-8 secretion, cyclo-oxygenase-2 expression and activated I-kappa-B-alpha and I-kappa-B-kinase signals in human colon epithelial cell line HT-29. Analysis of the mechanism of inhibition
Alpha-macroglobulin
-
moderate inhibitor
-
diethyl dicarbonate
-
-
diethyldicarbonate
-
moderate inhibitor
Diethylenetriaminepentaacetic acid
-
-
dithiothreitol
-
-
genistein
-
broad spectrum tyrosine kinase inhibitor, significantly inhibits BFT-stimulated interleukin-8 production
germ agglutinin
-
inhibits BFT biological activity on HT29/C1 cells but not binding of Alexa 488-labeled BFT to HT29/C1 cells
-
GM6001
-
significantly reduces Alexa 488-labeled BFT binding
PP2
-
selective Src-family tyrosine kinase inhibitor, significantly inhibits ca. 73% of BFT-stimulated interleukin-8 production
SB203580
-
p38 inhibitor, 0.01 mM inhibits ca. 80% of BFT-stimulated interleukin-8 production
subtilisin A
-
inhibits both BFT biological activity on HT29/C1 cells and nearly 90% of binding of Alexa 488-labeled BFT
-
Thermolysin
-
inhibits both BFT biological activity on HT29/C1 cells and nearly 90% of binding of Alexa 488-labeled BFT
-
thimerosal
-
i.e. sodium ethylmercurithiosalicylate
tyrphostin AG1478
-
selective epidermal growth factor receptor tyrosine kinase inhibitor, significantly inhibits ca. 64% of BFT-stimulated interleukin-8 production
U126
-
inhibits both basal and BFT-augmented extracellular signal-related kinase phosphorylation, 0.01 mM inhibits ca. 80% of BFT-stimulated interleukin-8 production
additional information
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