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3.4.24.74: fragilysin

This is an abbreviated version!
For detailed information about fragilysin, go to the full flat file.

Word Map on EC 3.4.24.74

Reaction

Broad proteolytic specificity, bonds hydrolysed including -Gly-/-Leu-, -Met-/-Leu-, -Phe-/-Leu-, -Cys-/-Leu-, Leu-/-Gly =

Synonyms

B. fragilis enterotoxin, Baceroides fragilis enterotoxin, Bacillus fragilis toxin, Bacteroides fragilis enterotoxin, Bacteroides fragilis enterotoxin-2, Bacteroides fragilis toxin, BFT, BFT-1, BFT-2, BFT-3, BFT2, Enterotoxin, FRA3, fragilysin-2, fragilysin-3, Korea-BFT, More, toxin-2

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.74 fragilysin

Engineering

Engineering on EC 3.4.24.74 - fragilysin

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
A394E
-
mutation does not affect BFT processing or secretion
E349A
G355R
-
expression of BFT similar to that of wild type
H348D
-
smaller amounts of BFT compared to wild type
H348Y/H352Y/H358Y
H352Y
H358Y
-
expression of BFT similar to that of wild type
M366R
-
smaller amounts of BFT compared to wild type
H352Y
-
Alexa-488-labeled BFT binding to HT29/C1 not blocked
-
additional information