3.4.24.74: fragilysin
This is an abbreviated version!
For detailed information about fragilysin, go to the full flat file.
Word Map on EC 3.4.24.74
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3.4.24.74
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staphylococcal
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aureus
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enterotoxigenic
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heat-labile
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superantigens
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heat-stable
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cholera
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diarrhea
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clostridium
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perfringens
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lymphocyte
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t-cells
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vaccine
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poisoning
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mucosal
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milk
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vibrio
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ifn-gamma
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outbreak
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serotype
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sta
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serogroups
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anergy
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foodborne
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enteropathogenic
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ganglioside
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gm1
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hydrophila
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exotoxin
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methicillin-resistant
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hemolysin
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cytotoxin
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ileal
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toxigenic
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stool
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agglutination
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emetic
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enterocolitica
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shiga
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toxin-producing
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retail
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coagulase
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rotavirus
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b-subunits
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medicine
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methicillin
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holotoxin
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antitoxin
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toxoid
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pyrogen
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anti-cd3
- 3.4.24.74
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staphylococcal
- aureus
- enterotoxigenic
-
heat-labile
-
superantigens
-
heat-stable
- cholera
-
diarrhea
- clostridium
- perfringens
- lymphocyte
- t-cells
- vaccine
- poisoning
- mucosal
- milk
- vibrio
- ifn-gamma
-
outbreak
-
serotype
- sta
-
serogroups
-
anergy
- foodborne
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enteropathogenic
- ganglioside
- gm1
- hydrophila
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exotoxin
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methicillin-resistant
- hemolysin
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cytotoxin
- ileal
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toxigenic
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stool
-
agglutination
-
emetic
- enterocolitica
-
shiga
-
toxin-producing
-
retail
- coagulase
- rotavirus
-
b-subunits
- medicine
- methicillin
-
holotoxin
- antitoxin
- toxoid
-
pyrogen
-
anti-cd3
Reaction
Broad proteolytic specificity, bonds hydrolysed including -Gly-/-Leu-, -Met-/-Leu-, -Phe-/-Leu-, -Cys-/-Leu-, Leu-/-Gly =
Synonyms
B. fragilis enterotoxin, Baceroides fragilis enterotoxin, Bacillus fragilis toxin, Bacteroides fragilis enterotoxin, Bacteroides fragilis enterotoxin-2, Bacteroides fragilis toxin, BFT, BFT-1, BFT-2, BFT-3, BFT2, Enterotoxin, FRA3, fragilysin-2, fragilysin-3, Korea-BFT, More, toxin-2
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medicine
additional information
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among stool strains from colon cancer patients, bft-1 is found to be more common than bft-2, isoform bft-1 is also found in almost all isolates from extraintestinal sites, strain NCTC 11295 harbours the isoform bft-2
medicine
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stimulates interleukin-8 secretion by human intestinal epithelial HT29/C1 cells, biological active BFT, but not serum, is required for interleukin-8 production, NF-kB, tyrosine kinase and mitogen activated protein kinase signaling pathways are involved in BFT-induced interleukin-8 stimulation
medicine
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oral administration with lower-dose biologically active recombinant isoform BFT-2 inhibits colorectal tumorigenesis in mice
medicine
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stimulates interleukin-8 secretion by human intestinal epithelial HT29/C1 cells, biological active BFT, but not serum, is required for interleukin-8 production, NF-kB, tyrosine kinase and mitogen activated protein kinase signaling pathways are involved in BFT-induced interleukin-8 stimulation
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medicine
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among stool strains from colon cancer patients, bft-1 is found to be more common than bft-2, isoform bft-1 is also found in almost all isolates from extraintestinal sites, strain NCTC 11295 harbours the isoform bft-2
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intestinal epithelial cells in vitro possess a specific membrane BFT receptor that is distinct from E-cadherin
additional information
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single point mutations in the zinc-binding metalloprotease motif do not affect BFT processing but do reduce or eliminate BFT biologic activity in vitro
additional information
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intestinal epithelial cells in vitro possess a specific membrane BFT receptor that is distinct from E-cadherin
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