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Literature summary for 3.4.24.74 extracted from
- Fragilysin (2004), Handbook Of Proteolytic Enzymes(Barrett,A. J. ,Rawlings,N. D. ,Woessner,J. F. ,Eds. )Academic Press, 1, 588-591.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | - |
Bacteroides fragilis |  |
| diethyl dicarbonate | - |
Bacteroides fragilis | |
| Diethylenetriaminepentaacetic acid | - |
Bacteroides fragilis | |
| EDTA | - |
Bacteroides fragilis | |
| Zincov | - |
Bacteroides fragilis | |
| Zn2+ | inhibits at higher concentrations | Bacteroides fragilis | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | stimulates at lower concentrations | Bacteroides fragilis | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 20600 | - |
cleaved to its enzymatically active secreted form | Bacteroides fragilis |
| 44400 | - |
preproprotein | Bacteroides fragilis |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacteroides fragilis | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| 2000-3000fold purified by sequential ammonium sulfate precipitation, ion-exchange chromatography, hydrophobic chromatography, high resolution ion-exchange chromatography | Bacteroides fragilis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| actin + H2O | - |
Bacteroides fragilis | ? | - |
? | |
| alpha1-proteinase inhibitor + H2O | - |
Bacteroides fragilis | ? | - |
? | |
| collagen type IV + H2O | - |
Bacteroides fragilis | ? | - |
? | |
| E-cadherin + H2O | cleaves the extracellular domain | Bacteroides fragilis | ? | - |
? | |
| Fibrinogen + H2O | - |
Bacteroides fragilis | ? | - |
? | |
| Gelatin + H2O | - |
Bacteroides fragilis | ? | - |
? | |
| human complement C3 + H2O | - |
Bacteroides fragilis | ? | - |
? | |
| additional information | cleaves at Cys-Leu, Ser-Leu, Thr-Leu, Gly-Leu or Leu-Gly peptide bonds in a number of proteins | Bacteroides fragilis | ? | - |
? | |
| myosin + H2O | - |
Bacteroides fragilis | ? | - |
? | |
| p-phenylazobenzyl-oxycarbonyl-Pro-Leu-Gly-Pro-D-Arg + H2O | - |
Bacteroides fragilis | ? | - |
? | |
| tropomyosin + H2O | - |
Bacteroides fragilis | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Bacteroides fragilis enterotoxin | - |
Bacteroides fragilis |
| BFT | - |
Bacteroides fragilis |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 4 | 20 | unstable and rapidly autodigests above 37°C | Bacteroides fragilis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
- |
Bacteroides fragilis |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 4 | 10 | - |
Bacteroides fragilis |
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Release 2023.1 (January 2023)
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