Literature summary for 3.4.24.74 extracted from

Wu, S.; Powell, J.; Mathioudakis, N.; Kane, S.; Fernandez, E.; Sears, C.L.
Bacteroides fragilis enterotoxin induces intestinal epithelial cell secretion of interleukin-8 through mitogen-activated protein kinases and a tyrosine kinase-regulated nuclear factor-kappaB pathway (2004), Infect. Immun., 72, 5832-5839.

Search for more literature for 3.4.24.74

Application

Application	Comment	Organism
medicine	stimulates interleukin-8 secretion by human intestinal epithelial HT29/C1 cells, biological active BFT, but not serum, is required for interleukin-8 production, NF-kB, tyrosine kinase and mitogen activated protein kinase signaling pathways are involved in BFT-induced interleukin-8 stimulation	Bacteroides fragilis

Inhibitors

Inhibitors	Comment	Organism	Structure
genistein	broad spectrum tyrosine kinase inhibitor, significantly inhibits BFT-stimulated interleukin-8 production	Bacteroides fragilis
PP2	selective Src-family tyrosine kinase inhibitor, significantly inhibits ca. 73% of BFT-stimulated interleukin-8 production	Bacteroides fragilis
SB203580	p38 inhibitor, 0.01 mM inhibits ca. 80% of BFT-stimulated interleukin-8 production	Bacteroides fragilis
tyrphostin AG1478	selective epidermal growth factor receptor tyrosine kinase inhibitor, significantly inhibits ca. 64% of BFT-stimulated interleukin-8 production	Bacteroides fragilis
U126	inhibits both basal and BFT-augmented extracellular signal-related kinase phosphorylation, 0.01 mM inhibits ca. 80% of BFT-stimulated interleukin-8 production	Bacteroides fragilis

Organism

Organism	UniProt	Comment	Textmining
Bacteroides fragilis	-	-	-
Bacteroides fragilis 086-5443-2-2	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Bacteroides fragilis

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
Baceroides fragilis enterotoxin	-	Bacteroides fragilis
Bacteroides fragilis toxin	-	Bacteroides fragilis
BFT	-	Bacteroides fragilis

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Release 2023.1 (January 2023)