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3.4.24.69: bontoxilysin

This is an abbreviated version!
For detailed information about bontoxilysin, go to the full flat file.

Word Map on EC 3.4.24.69

Reaction

Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevin (also known as neuronal vesicle-associated membrane protein, VAMP), synaptosome-associated protein of 25 kDa (SNAP25) or syntaxin. No detected action on small molecule substrates =

Synonyms

abobotulinumtoxinA, antigen E, Balc424, BoNT, BoNT A, BoNT B, BoNT E, BoNT F, BoNT F/A, BoNT LC, BoNT LC/A, BoNT serotype A, BoNT serotype E, BoNT serotype F, BoNT-A, BoNT-C, BoNT-D, BoNT-E, BoNT-F, BoNT/A, BoNT/A LC, BoNT/A Lc endopeptidase, BoNT/A-LC, BoNT/A1, BoNT/A2, BoNT/A3, BoNT/A4, BoNT/A5, BoNT/A6, BoNT/A8, BoNT/B, BoNT/B light chain protease, BoNT/B-LC, BoNT/B1, BoNT/B6, BoNT/C, BoNT/C1, BoNT/C1-LC, BoNT/C3, BoNT/CD, BoNT/D, BoNT/E, BoNT/F, BoNT/F proteolytic F toxin, BoNT/F-LC, BoNT/F1, BoNT/F5, BoNT/F6, BoNT/F7, BoNT/F9, BoNT/FA, BoNT/G, BoNT/HA, BoNT/T, BoNT/X, BoNTA, BoNTA endopeptidase, BoNTB, BoNTC, BoNTE, BoNTF, Bontoxilysin C1, botox A, botulinum A neurotoxin light chain, Botulinum neurotoxin, botulinum neurotoxin a, botulinum neurotoxin A light chain, botulinum neurotoxin A protease, botulinum neurotoxin A subtype 1, botulinum neurotoxin A subtype 2, botulinum neurotoxin A subtype 6, botulinum neurotoxin A3, botulinum neurotoxin A4, botulinum neurotoxin A8 subtype, botulinum neurotoxin B, botulinum neurotoxin B protease, botulinum neurotoxin C, botulinum neurotoxin D light chain, botulinum neurotoxin E, botulinum neurotoxin endopeptidase, botulinum neurotoxin F, botulinum neurotoxin serotype A, botulinum neurotoxin serotype A endopeptidase, botulinum neurotoxin serotype A light chain, botulinum neurotoxin serotype A protease, botulinum neurotoxin serotype B, botulinum neurotoxin serotype BA, botulinum neurotoxin serotype C1, botulinum neurotoxin serotype C1 light chain protease, botulinum neurotoxin serotype D, botulinum neurotoxin serotype E, botulinum neurotoxin serotype F, botulinum neurotoxin serotype FA, botulinum neurotoxin serotype G, botulinum neurotoxin serotype H, botulinum neurotoxin subtype A, botulinum neurotoxin subtype A3, botulinum neurotoxin subtype A4, botulinum neurotoxin subtype B6, botulinum neurotoxin subtype F5, botulinum neurotoxin type A, botulinum neurotoxin type A light chain, botulinum neurotoxin type B, botulinum neurotoxin type C, botulinum neurotoxin type D, botulinum neurotoxin type E, botulinum neurotoxin type F, botulinum neurotoxin type F light chain, botulinum neurotoxin type G, botulinum neurotoxin type HA, botulinum neurotoxin X, Botulinum neurotoxin-A, botulinum toxin, botulinum toxin C3, botulinum toxin serotype E, botulinum toxin serotype F, botulinum toxin type A, botulinum toxin type B, botulinum toxin type F, Botulinumtoxin A, BoTxA, C2 toxin, CDC69016, Clostridium botulinum A2 neurotoxin, Clostridium botulinum C2 toxin, Clostridium botulinum neurotoxin, Clostridium botulinum neurotoxin A1, Clostridium botulinum neurotoxin F, Clostridium botulinum neurotoxin serotype A, Clostridium botulinum neurotoxin serotype A light chain, Clostridium botulinum neurotoxin type E, Clostridium botulinum serotype D neurotoxin, CNT endopeptidase, D-4947 L-TC, daxibotulinumtoxinA, HCB, HCE, incobotulinumtoxinA, LC/A, LC/D, LC/F5, LC/HA, LC/X, LCA, LcB, lcc1, LCD, LCE, LCF, LHn/D, More, mosaic toxin, neurotoxin A, NT, onabotulinumtoxinA, serotype D botulinum neurotoxin, subtype A4 neurotoxin, TeNT, Tetanus neurotoxin, type A BoNT, type A botulinum neurotoxin, type A botulinum neurotoxin light chain, type A botulinum neurotoxin protease, type F toxin

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.69 bontoxilysin

KI Value

KI Value on EC 3.4.24.69 - bontoxilysin

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00016
(3R)-3-(2,4-dichlorophenyl)-N,5-dihydroxypentanamide
-
pH 7.4, 22.5°C
0.0017
(3R)-3-(4-chlorophenyl)-N,5-dihydroxypentanamide
-
pH 7.4, 22.5°C
0.0038
([[5-[[1-(4-ammoniobutyl)-2-phenyl-1H-indol-6-yl]carbonyl]-2-(3-hydroxyphenyl)thiophen-3-yl]acetyl]amino)oxidanide
-
pH 7.3, 37°C, hydroxyl-containing analogue of BoNTA endopeptidase
0.00129
2(9H-fluorene-2-carbonyl)benzoic acid
-
at pH 7.4 and 37°C
0.007
2-(5-{[1-(4-aminobutyl)-2-phenyl-1H-indol-6-yl]carbonyl}-2-phenylthiophen-3-yl)-N-hydroxyacetamide
-
pH not specified in the publication, temperature not specified in the publication
0.00129
2-(9H-fluorene-2-carbonyl)benzoic acid
-
pH and temperature not specified in the publication
0.06
2-mercapto-3-phenylpropionyl-R
-
pH 7.3, 37°C
0.06
2-mercapto-3-phenylpropionyl-RA
-
pH 7.3, 37°C
0.0007
2-mercapto-3-phenylpropionyl-RAAKML
-
pH 7.3, 37°C
0.03
2-mercapto-3-phenylpropionyl-RAT
-
pH 7.3, 37°C
0.003
2-mercapto-3-phenylpropionyl-RATAML
-
pH 7.3, 37°C
0.004
2-mercapto-3-phenylpropionyl-RATK
-
pH 7.3, 37°C
0.0007
2-mercapto-3-phenylpropionyl-RATKAL
-
pH 7.3, 37°C
0.0003
2-mercapto-3-phenylpropionyl-RATKM
-
pH 7.3, 37°C
0.0003
2-mercapto-3-phenylpropionyl-RATKML
-
pH 7.3, 37°C
0.0003
2-mercapto-3-phenylpropionyl-RATKMLGSG
-
pH 7.3, 37°C
0.002
2-mercapto-3-phenylpropionyl-RVTKML
-
pH 7.3, 37°C
0.004
2-[5-{[1-(4-aminobutyl)-2-phenyl-1H-indol-6-yl]carbonyl}-2-(3-hydroxyphenyl)thiophen-3-yl]-N-hydroxyacetamide
-
pH not specified in the publication, temperature not specified in the publication
0.0021
3-(2,4-dichlorophenyl)-5-(4-fluorophenethoxy)-N-hydroxypentanamide
A5HZZ9
at pH 7.4 and 37°C
0.001
3-(2,4-dichlorophenyl)-N1-(4-fluoro-2-methoxyphenyl)-N5-hydroxypentanediamide
A5HZZ9
at pH 7.4 and 37°C
0.00046
3-hydroxy-N'-[(E)-(3,4,5-trihydroxyphenyl)methylidene]naphthalene-2-carbohydrazide
A5HZZ9
pH and temperature not specified in the publication
0.00453
32-mer C-terminal peptide of LcA
-
full-length light chain of botulinum toxin A, in 50 mM HEPES, pH 7.4, at 37°C
-
0.06
4-(2-amino-3-sulfanylpropyl)benzamide
-
-
0.065
4-(2-amino-3-sulfanylpropyl)benzenesulfonamide
-
-
0.022
4-(2-amino-3-sulfanylpropyl)benzenesulfonic acid
-
-
0.0062
4-chloro-(3-fluorophenyl)methyl benzenesulfonamide
-
at pH 7.4 and 25°C
0.0032
4-chloro-N-[(4-fluorophenyl)methyl] pyridin-3-amine
-
at pH 7.4 and 25°C
0.00058
4-[((2S)-2-amino-3-[1-(1-benzylcarbamoyl-(2R)-2-phenylethylcarbamoyl)-(2S)-2-biphenyl-4-yl-ethylcarbamoyl]-3(S)sulfanylpropyl)]benzoic acid
-
-
0.00081
4-[((2S)-2-amino-3-[1-(1-benzylcarbamoyl-(2S)-2-(4-hydroxyphenyl)ethylcarbamoyl)-(2S)-2-biphenyl-4-yl-ethylcarbamoyl]-3(S)sulfanylpropyl)]benzoic acid
-
-
0.00035
4-[((2S)-2-amino-3-[1-(1-benzylcarbamoyl-(2S)-2-phenylethylcarbamoyl)-(2S)-2-(1H-indol-3-yl)ethylcarbamoyl]-3(S)sulfanylpropyl)]benzoic acid
-
-
0.0005
4-[(2S)-2-amino-3-[1-(1-benzylcarbamoyl-(2S)-2-(3H-imidazol-4-yl)ethylcarbamoyl]-(2S)-2-biphenyl-4-ylethylcarbamoyl)-3(S)sulfanylpropyl]benzoic acid
-
-
0.00054
4-[(2S)-2-amino-3-[1-(1-benzylcarbamoyl-(2S)-2-methylbutylcarbamoyl-(2S)-2-biphenyl-4-ylethylcarbamoyl]-3(S)-sulfanylpropyl)] benzoic acid
-
-
0.00054
4-[(2S)-2-amino-3-[1-(1-benzylcarbamoyl-(2S)-2-phenylethylcarbamoyl)-(2R)-2-biphenyl-4-yl-ethylcarbamoyl]-3(S)sulfanylpropyl]benzoic acid
-
-
0.00017
4-[(2S)-2-amino-3-[1-(1-benzylcarbamoyl-(2S)-2-phenylethylcarbamoyl)-(2S)-2-(1-methyl-1H-indol-3-yl)ethylcarbamoyl]-3(S)sulfanylpropyl] benzoic acid
-
-
0.00022
4-[(2S)-2-amino-3-[1-(1-benzylcarbamoyl-(2S)-2-phenylethylcarbamoyl)-(2S)-2-naphthalen-1-yl-ethylcarbamoyl]-3(S)sulfanylpropyl] benzoic acid
-
-
0.00016
4-[(2S)-2-amino-3-[1-(1-benzylcarbamoyl-(2S)-2-phenylethylcarbamoyl]-3(S)sulfanylpropyl)] benzoic acid
-
-
0.00002
4-[(2S)-2-amino-3-[1-(2S)-2-benzol[beta]thiophen-3-yl-1-benzylcarbamoylethylcarbamoyl-(2S)-2-biphenyl-4-yl-ethylcarbamoyl]-3-(S)-sulfanylpropyl] benzoic acid
-
-
0.22
Ac-SNKTRIDEACQRATKML-NH2
-
pH 7.3, 37°C
0.004
Ac-SNKTRIDEAN(D)CRATKML-NH2
-
pH 7.3, 37°C
0.65
Ac-SNKTRIDEAN(D)QCRATKML-NH2
-
pH 7.3, 37°C
0.11
Ac-SNKTRIDEANCRATKML-NH2
-
pH 7.3, 37°C
2
Ac-SNKTRIDEANQCATKML-NH2
-
pH 7.3, 37°C
0.00028
AQVDEVVDIMRVNVDKVLERDQ
-
-
0.0018
chicoric acid iso-propyl ester
A5HZZ9
pH and temperature not specified in the publication
0.002
CRATKML
-
pH 6.5, 22°C
0.00032
Dyngo-4a
A5HZZ9
pH and temperature not specified in the publication
0.0013
GGPPAPPPNLTSNRRLQQTQAQVDEVVDIMRVNVDKVLERDQ
-
-
0.000096
GRKKRRQRRRPPQC
-
pH 7.4, 37°C
0.000034
LQQTQAQVDEVVDIMRVNVDKVLERDQ
-
-
0.00046
N-hydroxy-2-(tricyclo[3.3.1.13,7]dec-1-yl)acetamide
A5HZZ9
at pH 7.4 and 37°C
0.001
PPPNLTSNRRLQQTQAQVDEVVDIMRVNVDKVLERDQ
-
-
0.000158 - 0.000664
RRGC
0.000358
RRGF
-
pH 7.4, 37°C
0.000786
RRGI
-
pH 7.4, 37°C
0.000845
RRGM
-
pH 7.4, 37°C
0.0019
TSNRRLQQTQAQVDEVVDIMRVNVDKVLERDQ
-
-
0.009
VVDIMRVNVDKVLERDQ
-
-
0.007
[[(5-[[1-(4-ammoniobutyl)-2-phenyl-1H-indol-6-yl]carbonyl]-2-phenylthiophen-3-yl)acetyl]amino]oxidanide
-
pH 7.3, 37°C, wild-type BoNTA endopeptidase
additional information
additional information
-