3.4.24.14: procollagen N-endopeptidase
This is an abbreviated version!
For detailed information about procollagen N-endopeptidase, go to the full flat file.
Word Map on EC 3.4.24.14
Reaction
Cleaves the N-propeptide of collagen chain alpha1(I) at Pro-/-Gln and of alpha1(II) and alpha2(I) at Ala-/-Gln
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Synonyms
ADAM-TS2, ADAMTS 3, ADAMTS proteinase, ADAMTS-2, ADAMTS14, ADAMTS2, ADAMTS3, aminoprocollagen endopeptidase, aminoprocollagen peptidase, aminoterminal procollagen peptidase, PC I-NP, pNPI, procollagen ADAMTS, procollagen aminopeptidase, procollagen aminoterminal protease, Procollagen I N-proteinase, Procollagen I/II amino-propeptide processing enzyme, procollagen I/II N-endopeptidase, procollagen III N-endopeptidase, procollagen III N-proteinase, Procollagen N-endopeptidase, procollagen N-protease, procollagen N-proteinase, procollagen N-terminal peptidase, procollagen N-terminal proteinase, Procollagen peptidase, type I/II procollagen N-proteinase
ECTree
Inhibitors
Inhibitors on EC 3.4.24.14 - procollagen N-endopeptidase
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alpha2-Macroglobulin
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-
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ammonium persulfate
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94% inhibition at 10 micromol/ml
decanoyl-Arg-Val-Lys-Arg-chloromethylketone
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-
ferrocene derivatives
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-
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metal chelator
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potent inhibitor
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NaCl
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40% inhibition at 0.3 M
p-hydroxymercuribenzoate
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-
Reducing agent
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potent inhibitor
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TIMP-3
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inhibits ADAMTS-2 in vitro in the presence of procollagen I and II, addition of heparin enhances the ability of TIMP-3 to inhibit the enzyme
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Tris-HCl
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80% inhibition at 0.3 M
1,10-phenanthroline
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1,10-phenanthroline
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100% inhibition at 1 mM
1,10-phenanthroline
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100% inhibition at 1 mM
1,10-phenanthroline
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45% inhibition at 0.1 mM
2,2'-dipyridyl
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93% inhibition at 10 mM
2,2'-dipyridyl
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57% inhibition at 1 mM
2-mercaptoethanol
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2-mercaptoethanol
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26% inhibition at 1 mM
2-mercaptoethanol
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78% inhibition at 1 mM
2-mercaptoethanol
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81% inhibition at 1150 mM
Cd2+
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potent inhibitor
Cd2+
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moderate inhibitor
Co2+
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20% inhibition at 0.01 mM
concanavalin A
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-
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concanavalin A
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91% inhibition at 50 micromol/ml
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concanavalin A
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potent inhibitor
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concanavalin A
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74% inhibition at 50 micromol/ml
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Cu2+
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-
Cu2+
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60% inhibition at 0.01 mM
Cu2+
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63% inhibition at 0.1 mM
dithiothreitol
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88% inhibition at 1 mM
dithiothreitol
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77% inhibition at 0.5 mM
EDTA
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-
EDTA
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100% inhibition at 7.5 mM
EDTA
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100% inhibition at 7.5 mM
EDTA
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100% inhibition at 10 mM
EDTA
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100% inhibition at 2.5 mM
Fetal bovine serum
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-
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Fetal bovine serum
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34% inhibition at concentration of 2%
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Fetal bovine serum
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56% inhibition at concentration of 2%
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heparan sulfate
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-
heparan sulfate
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38% inhibition at 0.5 micromol/ml
heparan sulfate
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potent inhibitor
heparan sulfate
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50% inhibition at 0.05 micromol/ml
heparin
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76% inhibition at 0.05 micromol/ml
heparin
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52-58% inhibition at 0.05 micromol/ml
heparin
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potent inhibitor
heparin
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76% inhibition at 0.05 micromol/ml
Mg2+
-
-
Mg2+
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64% inhibition at 5 mM
Mn2+
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-
Mn2+
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49% inhibition at 5 mM
Ni2+
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-
Ni2+
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19% inhibition at 0.01 mM
Ni2+
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42% inhibition at 0.1 mM
papilin
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phosphate
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phosphate
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,46% inhibition at 2 mM
phosphate
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100% inhibition at 10 mM sodium phosphate
Poly-L-aspartate
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-
Poly-L-aspartate
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24% inhibition at 50 micromol/ml
Poly-L-aspartate
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81% inhibition at 10 micromol/ml
Poly-L-glutamate
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-
Poly-L-glutamate
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40% inhibition at 50 micromol/ml
Poly-L-glutamate
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89% inhibition at 10 micromol/ml
SDS
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-
SDS
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79% inhibition at 50 micromol/ml
SDS
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84% inhibition at 50 micromol/ml
TIMP3
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-
Zn2+
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-
Zn2+
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73% inhibition at 0.01 mM
Zn2+
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92% inhibition at 0.1 mM
additional information
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not inhibited by serine protease inhibitors, lysine or serum
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additional information
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not inhibited by serine proteinase inhibitor
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additional information
no inhibition by AEBSF, NEM and PMSF
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additional information
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not inhibited by TIMP-1, TIMP-2 and TIMP-4
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additional information
no inhibition by AEBSF, NEM and PMSF
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additional information
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no inhibition by AEBSF, NEM and PMSF
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