3.4.24.14: procollagen N-endopeptidase

This is an abbreviated version!
For detailed information about procollagen N-endopeptidase, go to the full flat file.

Reaction

Cleaves the N-propeptide of collagen chain alpha1(I) at Pro-/-Gln and of alpha1(II) and alpha2(I) at Ala-/-Gln =

Synonyms

ADAM-TS2, ADAMTS 3, ADAMTS proteinase, ADAMTS-2, ADAMTS14, ADAMTS2, ADAMTS3, aminoprocollagen endopeptidase, aminoprocollagen peptidase, aminoterminal procollagen peptidase, PC I-NP, pNPI, procollagen ADAMTS, procollagen aminopeptidase, procollagen aminoterminal protease, Procollagen I N-proteinase, Procollagen I/II amino-propeptide processing enzyme, procollagen I/II N-endopeptidase, procollagen III N-endopeptidase, procollagen III N-proteinase, Procollagen N-endopeptidase, procollagen N-protease, procollagen N-proteinase, procollagen N-terminal peptidase, procollagen N-terminal proteinase, Procollagen peptidase, type I/II procollagen N-proteinase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.14 procollagen N-endopeptidase

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Results	in table
7	Activating Compound
18	AA Sequence
1	Application
1	CAS Registry Number
22	Cloned(Commentary)
219	Disease/ Diagnostics
5	Expression
53	General Information
6	General Stability
113	Inhibitors
2	Ki Value [mM]
17	KM Value [mM]
19	Localization
62	Metals/Ions
11	Molecular Weight [Da]
88	Natural Substrates/ Products (Substrates)
61	Organism
18	pH Optimum
9	pH Range
2	pH Stability
12	Posttranslational Modification
5	Protein Variants
22	Purification (Commentary)
1	Reaction
1	Reaction Type
57	Reference
87	Source Tissue
2	Storage Stability
213	Substrates and Products (Substrate)
4	Subunits
94	Synonyms
3	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Temperature Stability [°C]
2	Turnover Number [1/s]

Expression

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Expression on EC 3.4.24.14 - procollagen N-endopeptidase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

enzyme exxpression is upregulated by glucocorticoids

Homo sapiens

O15072, O95450, Q8WXS8

734611

enzyme synthesis is increased by TGF beta in vitro and in fibrotic lesions in vivo. ADAMTS2 overexpression by macrophages and peripheral blood monocytes is stimulated by glucocorticoids

2 entries

upregulated expression of ADAMTS2 in failing human hearts

Homo sapiens

O95450

753779

upregulated expression of ADAMTS2 in hypertrophic murine hearts

Mus musculus

Q8C9W3

753779

enzyme synthesis is increased by TGF beta in vitro and in fibrotic lesions in vivo. ADAMTS2 overexpression by macrophages and peripheral blood monocytes is stimulated by glucocorticoids

Homo sapiens

O15072, O95450, Q8WXS8

754590

enzyme synthesis is increased by TGF beta in vitro and in fibrotic lesions in vivo. ADAMTS2 overexpression by macrophages and peripheral blood monocytes is stimulated by glucocorticoids

Mus musculus

Q8C9W3

754590