3.4.24.14: procollagen N-endopeptidase
This is an abbreviated version!
For detailed information about procollagen N-endopeptidase, go to the full flat file.
Word Map on EC 3.4.24.14
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3.4.24.14
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procollagens
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thrombospondin
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disintegrin
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ehlers-danlos
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dermatosparaxis
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n-propeptide
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c-proteinase
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imperfecta
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aminopropeptide
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pro-alpha
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disintegrin-like
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adamts-3
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dermatosparactic
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col5a1
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hennekam
- 3.4.24.14
- procollagens
- thrombospondin
-
disintegrin
- ehlers-danlos
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dermatosparaxis
- n-propeptide
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c-proteinase
- imperfecta
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aminopropeptide
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pro-alpha
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disintegrin-like
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adamts-3
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dermatosparactic
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col5a1
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hennekam
Reaction
Cleaves the N-propeptide of collagen chain alpha1(I) at Pro-/-Gln and of alpha1(II) and alpha2(I) at Ala-/-Gln =
Synonyms
ADAM-TS2, ADAMTS 3, ADAMTS proteinase, ADAMTS-2, ADAMTS14, ADAMTS2, ADAMTS3, aminoprocollagen endopeptidase, aminoprocollagen peptidase, aminoterminal procollagen peptidase, PC I-NP, pNPI, procollagen ADAMTS, procollagen aminopeptidase, procollagen aminoterminal protease, Procollagen I N-proteinase, Procollagen I/II amino-propeptide processing enzyme, procollagen I/II N-endopeptidase, procollagen III N-endopeptidase, procollagen III N-proteinase, Procollagen N-endopeptidase, procollagen N-protease, procollagen N-proteinase, procollagen N-terminal peptidase, procollagen N-terminal proteinase, Procollagen peptidase, type I/II procollagen N-proteinase
ECTree
3.4.24.14 procollagen N-endopeptidaseAdvanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 3.4.24.14 - procollagen N-endopeptidase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
pro-collagen + H2O
collagen + collagen N-propeptide
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?
procollagen I + H2O
?
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?
procollagen I + H2O
?
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31037, 31041, 37034, 37035, 37036, 37037, 37039, 37040, 37041, 37042, 37043, 37044, 37046, 37050, 37051
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?
procollagen II + H2O
?
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?
procollagen II + H2O
?
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31037, 31041, 37034, 37035, 37036, 37037, 37039, 37040, 37041, 37042, 37043, 37044, 37046, 37050, 37051
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?
additional information
?
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ADAMTS14 processes type I procollagen (alpha1 and alpha2 chains) and its strong sequence homology with ADAMTS2 suggests that the cleavage should occur at the same site
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?
additional information
?
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ADAMTS14 processes type I procollagen (alpha1 and alpha2 chains) and its strong sequence homology with ADAMTS2 suggests that the cleavage should occur at the same site
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?
additional information
?
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ADAMTS14 processes type I procollagen (alpha1 and alpha2 chains) and its strong sequence homology with ADAMTS2 suggests that the cleavage should occur at the same site
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?
additional information
?
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sequence homology of ADAMTS2 cleavage sites in alpha chain types I-III fibrillar collagens from different species, overview. The bovine enzyme ADAMTS2 cleaves at sites 158NFAP-/-QLSY165 in chain alpha1(I), and at 178NFAA-/-QMAG185 in chain alpha1(II), as well as at 76NFAA-/-QFDA83 in chains alpha2(I), respectively
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?
additional information
?
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sequence homology of ADAMTS2 cleavage sites in alpha chain types I-III fibrillar collagens from different species, overview. The bovine enzyme ADAMTS2 cleaves at sites 158NFAP-/-QLSY165 in chain alpha1(I), and at 178NFAA-/-QMAG185 in chain alpha1(II), as well as at 76NFAA-/-QFDA83 in chains alpha2(I), respectively
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?
additional information
?
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sequence homology of ADAMTS2 cleavage sites in alpha chain types I-III fibrillar collagens from different species, overview. The bovine enzyme ADAMTS2 cleaves at sites 158NFAP-/-QLSY165 in chain alpha1(I), and at 178NFAA-/-QMAG185 in chain alpha1(II), as well as at 76NFAA-/-QFDA83 in chains alpha2(I), respectively
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?
additional information
?
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E2R8G2
sequence homology of ADAMTS2 cleavage sites in alpha chain types I-III fibrillar collagens from different species, overview. The dog enzyme ADAMTS2 cleaves at sites 154NFAP-/-QMSY161 in chain alpha1(I), and at 147FSP-/-QYDS154 in chain alpha1(III), as well as at 76NFAA-/-QYDG83 in chains alpha2(I)
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?
additional information
?
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sequence homology of ADAMTS2 cleavage sites in alpha chain types I-III fibrillar collagens from different species, overview. The chicken enzyme ADAMTS2 cleaves at sites 148NFAP-/-QMSY155 in chain alpha1(I), as well as at 74NFAA-/-QYDP81 in chains alpha2(I)
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?
additional information
?
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ADAMTS14 processes type I procollagen (alpha1 and alpha2 chains) and its strong sequence homology with ADAMTS2 suggests that the cleavage should occur at the same site
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?
additional information
?
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ADAMTS14 processes type I procollagen (alpha1 and alpha2 chains) and its strong sequence homology with ADAMTS2 suggests that the cleavage should occur at the same site
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?
additional information
?
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ADAMTS14 processes type I procollagen (alpha1 and alpha2 chains) and its strong sequence homology with ADAMTS2 suggests that the cleavage should occur at the same site
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?
additional information
?
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ADAMTS3 cleaves the aminopropeptide of type II collagen in swarm rat chondrosarcoma RCS-LTC cells stably transfected with human ADAMTS3
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?
additional information
?
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ADAMTS3 cleaves the aminopropeptide of type II collagen in swarm rat chondrosarcoma RCS-LTC cells stably transfected with human ADAMTS3
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?
additional information
?
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ADAMTS3 cleaves the aminopropeptide of type II collagen in swarm rat chondrosarcoma RCS-LTC cells stably transfected with human ADAMTS3
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?
additional information
?
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sequence homology of ADAMTS2 cleavage sites in alpha chain types I-III fibrillar collagens from different species, overview. The human enzyme ADAMTS2 cleaves at sites 158NFAP-/-QLSY165 in chain alpha1(I), at 178NFAA-/-QMAG185 in chain alpha1(II), and at 150NYSP-/-QYDS157 in chain alpha1(III), as well as at 76NFAA-/-QYDG83 in chains alpha2(I), respectively
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?
additional information
?
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sequence homology of ADAMTS2 cleavage sites in alpha chain types I-III fibrillar collagens from different species, overview. The human enzyme ADAMTS2 cleaves at sites 158NFAP-/-QLSY165 in chain alpha1(I), at 178NFAA-/-QMAG185 in chain alpha1(II), and at 150NYSP-/-QYDS157 in chain alpha1(III), as well as at 76NFAA-/-QYDG83 in chains alpha2(I), respectively
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?
additional information
?
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sequence homology of ADAMTS2 cleavage sites in alpha chain types I-III fibrillar collagens from different species, overview. The human enzyme ADAMTS2 cleaves at sites 158NFAP-/-QLSY165 in chain alpha1(I), at 178NFAA-/-QMAG185 in chain alpha1(II), and at 150NYSP-/-QYDS157 in chain alpha1(III), as well as at 76NFAA-/-QYDG83 in chains alpha2(I), respectively
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?
additional information
?
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preferential substrate specificity of ADAMTS2, 3, and 14 regarding the different fibrillar procollagens is dictated first by their tissue distribution
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?
additional information
?
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preferential substrate specificity of ADAMTS2, 3, and 14 regarding the different fibrillar procollagens is dictated first by their tissue distribution
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?
additional information
?
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preferential substrate specificity of ADAMTS2, 3, and 14 regarding the different fibrillar procollagens is dictated first by their tissue distribution
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?
additional information
?
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sequence homology of ADAMTS2 cleavage sites in alpha chain types I-III fibrillar collagens from different species, overview. The murine enzyme ADAMTS2 cleaves at sites 148NFAS-/-QMSY155 in chain alpha1(I), at 178NFAA-/-QMAG185 in chain alpha1(II), and at 151NYSP-/-QFDS158 in chain alpha1(III), as well as at 81NFAA-/-QYSD89 in chains alpha2(I), respectively
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?
additional information
?
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preferential substrate specificity of ADAMTS2, 3, and 14 regarding the different fibrillar procollagens is dictated first by their tissue distribution
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-
?
additional information
?
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sequence homology of ADAMTS2 cleavage sites in alpha chain types I-III fibrillar collagens from different species, overview. The rat enzyme ADAMTS2 cleaves at sites 148NFAS-/-QMSY155 in chain alpha1(I), at 110NFAA-/-QMAG117 in chain alpha1(II), and at 15NYSP-/-QFDS158 in chain alpha1(III), as well as at 81NFAA-/-QYSD89 in chains alpha2(I), respectively
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?
