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Literature summary for 3.4.24.14 extracted from

  • Canty-Laird, E.G.; Lu, Y.; Kadler, K.E.
    Stepwise proteolytic activation of type I procollagen to collagen within the secretory pathway of tendon fibroblasts in situ (2012), Biochem. J., 441, 707-717.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.14

Inhibitors

Inhibitors Comment Organism Structure
decanoyl-Arg-Val-Lys-Arg-chloromethylketone
-
 Gallus gallus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum brefeldin A treatment of tendon explant cultures shows that N-proteinase activity is present in the resulting fused ER (endoplasmic reticulum)-Golgi compartment Gallus gallus 5783
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
procollagen I + H2O Gallus gallus
-
 pCCollagen I + oligopeptide
-
 ?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
tendon metatarsal tendons obtained from E13 chick embryos Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
procollagen I + H2O
-
 Gallus gallus pCCollagen I + oligopeptide
-
 ?

Synonyms

Synonyms Comment Organism
procollagen N-proteinase
-
 Gallus gallus

General Information

General Information Comment Organism
metabolism the N-propeptides of collagen are removed first, most probably in the Golgi or in the ERGIC (ER-Golgi intermediate compartment). In contrast, the C-propeptides are cleaved in a post-Golgi compartment Gallus gallus