3.4.22.41: cathepsin F
This is an abbreviated version!
For detailed information about cathepsin F, go to the full flat file.
Word Map on EC 3.4.22.41
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3.4.22.41
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cathepsins
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diagnostics
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westermani
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viroid
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paragonimus
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f-like
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food industry
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metalloproteinase-10
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cystatin-like
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viverrini
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medicine
- 3.4.22.41
- cathepsins
- diagnostics
- westermani
- viroid
- paragonimus
-
f-like
- food industry
- metalloproteinase-10
-
cystatin-like
- viverrini
- medicine
Reaction
The recombinant enzyme cleaves synthetic substrates with Phe and Leu (better than Val) in P2, with high specificity constant (kcat/Km) comparable to that of cathepsin L =
Synonyms
cat F, CatF, cathepsin f, cathepsin F-1, CATSF, CF-1, CF-11, CF-4, CF-6, cf1, CtF, CTSF, Ov-CF-1, PwCP1, PwCP10, PwCP11, PwCP2, PwCP3, PwCP4, PwCP5, PwCP6, PwCP7, PwCP8, PwCP9, Tci-CF-1
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Substrates Products
Substrates Products on EC 3.4.22.41 - cathepsin F
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REACTION DIAGRAM
Albumin + H2O
?
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substrate of isozyme CF-4 at pH 6.5 and CF-11 at pH 5.5 but not at neutral pH
-
-
?
benzyloxycarbonyl-Arg-Arg-4-methylcoumaryl-7-amide + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin + H2O
?
-
low activity
-
-
?
benzyloxycarbonyl-L-leucine-L-arginine-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-L-leucine-L-arginine + 7-amino-4-methylcoumarin
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high catalytic activity with isozymes CF-4 and CF-11
-
-
?
benzyloxycarbonyl-L-leucyl-L-arginyl-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-L-leucyl-L-arginine + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-L-phenylalanine-L-arginine-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-L-phenylalanine-L-arginine + 7-amino-4-methylcoumarin
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high catalytic activity with isozymes CF-4 and CF-11
-
-
?
benzyloxycarbonyl-Leu-Arg-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Leu-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Leu-Arg-4-methylcoumaryl-7-amide + H2O
benzyloxycarbonyl-Leu-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Leu-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Leu-Arg + 7-amino-4-methylcoumarin
-
high activity
-
-
?
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Phe-Arg-4-methylcoumaryl-7-amide + H2O
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
?
-
high activity
-
-
?
benzyloxycarbonyl-Val-Val-Arg-7-amido-4-methylcoumarin + H2O
?
-
very low activity
-
-
?
Collagen + H2O
?
-
substrate of isozyme CF-4 at pH 6.5 and CF-11 at pH 5.5 but not at neutral pH
-
-
?
Gelatin + H2O
?
purified CtF is capable of hydrolyzing 0.1% gelatin at pH 7.5
-
-
?
immunoglobulin A + H2O
?
-
substrate of isozyme CF-4 at pH 6.5 and CF-11 at pH 5.5 but not at neutral pH
-
-
?
immunoglobulin G + H2O
?
-
substrate of isozyme CF-4 at pH 6.5 and CF-11 at pH 5.5 but not at neutral pH
-
-
?
immunoglobulin M + H2O
?
-
substrate of isozyme CF-4 at pH 6.5 and CF-11 at pH 5.5 but not at neutral pH
-
-
?
N-acetyl-DEVD-7-amido-4-trifluoromethylcoumarin + H2O
N-acetyl-DEVD + 7-amino-4-trifluoromethylcoumarin
-
-
-
-
?
N-benzyloxycarbonyl-L-Arg-L-Arg-4-methylcoumarin 7-amide + H2O
N-benzyloxycarbonyl-L-Arg-L-Arg + 7-amino-4-methylcoumarin
-
-
?
N-benzyloxycarbonyl-L-Leu-L-Arg-4-methylcoumarin 7-amide + H2O
N-benzyloxycarbonyl-L-Leu-L-Arg + 7-amino-4-methylcoumarin
N-benzyloxycarbonyl-L-Phe-L-Arg-4-methylcoumarin 7-amide + H2O
N-benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
N-benzyloxycarbonyl-L-Val-L-Arg-4-methylcoumarin 7-amide + H2O
N-benzyloxycarbonyl-L-Val-L-Arg + 7-amino-4-methylcoumarin
-
-
?
tert-butyloxycarbonyl-Ala-Gly-Pro-Arg-7-amido-4-methylcoumarin + H2O
?
-
very low activity
-
-
?
tert-butyloxycarbonyl-Leu-Arg-7-amido-4-methylcoumarin + H2O
?
-
highest activity
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-
?
tert-butyloxycarbonyl-Val-Pro-Arg-7-amido-4-methylcoumarin + H2O
?
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very low activity
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-
?
tosyl-Gly-Pro-Arg-7-amido-4-methylcoumarin + H2O
?
-
very low activity
-
-
?
tosyl-Gly-Pro-Lys-7-amido-4-methylcoumarin + H2O
?
-
very low activity
-
-
?
?
-
substrate of isozyme CF-4 at pH 6.5 and CF-11 at pH 5.5 but not at neutral pH
-
-
?
Hemoglobin + H2O
?
-
cathepsin F and cathepsin B can work in concert to hydrolyse hemoglobin at low pH
-
-
?
N-benzyloxycarbonyl-L-Leu-L-Arg + 7-amino-4-methylcoumarin
-
-
?
N-benzyloxycarbonyl-L-Leu-L-Arg-4-methylcoumarin 7-amide + H2O
N-benzyloxycarbonyl-L-Leu-L-Arg + 7-amino-4-methylcoumarin
-
-
-
?
N-benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
-
-
?
N-benzyloxycarbonyl-L-Phe-L-Arg-4-methylcoumarin 7-amide + H2O
N-benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
-
-
?
?
-
-
the isozymes CF-4, CF-6, and CF-11 do not hydrolyze benzyloxycarbonyl-L-arginine-L-arginine-7-amido-4-methylcoumarin and benzyloxycarbonyl-L-arginine-7-amido-4-methylcoumarin
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-
?
additional information
?
-
-
the enzyme likely plays a regulatory role in the processing in the invariant chain that is assoviated with the major histocompatibility complex class II
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?
additional information
?
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the enzyme plays a role in tumor-induced angiogenesis, cell migration, proliferation, apoptosis, and connective tissue degradation
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-
?
additional information
?
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the enzyme is a cysteine protease and modifies low density lipoprotein particles in vitro
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-
?
additional information
?
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involved in atherosclerotic inflammatory processes
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-
?
additional information
?
-
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cathepsin F degrades extracellular matrix proteins more effectively than capthespin B1 at physiological pH
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-
?
additional information
?
-
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the fully activated cathepsin F cleaves fluorogenic-NHMec substrates with the preference Val-Leu-Arg>Leu-Arg>Phe-Arg>Arg-Arg with little or no activity against Pro-Arg or Pro-Lys substrates
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-
?
additional information
?
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the enzyme is not able to hydrolyze protein substrates such as azocasein, fibrinogen, and bovine serum albumin
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-
?
additional information
?
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the enzyme is not able to hydrolyze protein substrates such as azocasein, fibrinogen, and bovine serum albumin
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-
?
additional information
?
-
cathepsin F-1 is developmentally regulated
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-
?
additional information
?
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cathepsin F-1 is developmentally regulated
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-
?