3.4.22.41: cathepsin F

This is an abbreviated version!
For detailed information about cathepsin F, go to the full flat file.

Reaction

The recombinant enzyme cleaves synthetic substrates with Phe and Leu (better than Val) in P2, with high specificity constant (kcat/Km) comparable to that of cathepsin L =

Synonyms

cat F, CatF, cathepsin f, cathepsin F-1, CATSF, CF-1, CF-11, CF-4, CF-6, cf1, CtF, CTSF, Ov-CF-1, PwCP1, PwCP10, PwCP11, PwCP2, PwCP3, PwCP4, PwCP5, PwCP6, PwCP7, PwCP8, PwCP9, Tci-CF-1

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.41 cathepsin F

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Results	in table
9	Activating Compound
53	AA Sequence
6	Application
1	CAS Registry Number
20	Cloned(Commentary)
2	Crystallization (Commentary)
46	Disease/ Diagnostics
4	Expression
3	General Information
28	Inhibitors
4	kcat/KM [mM/s]
6	KM Value [mM]
16	Localization
3	Metals/Ions
17	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
40	Organism
2	PDB ID
7	pH Optimum
5	pH Range
7	pH Stability
2	pI Value
7	Posttranslational Modification
2	Protein Variants
6	Purification (Commentary)
2	Reaction
2	Reaction Type
30	Reference
1	Renatured (Commentary)
87	Source Tissue
4	Specific Activity [micromol/min/mg]
2	Storage Stability
47	Substrates and Products (Substrate)
5	Subunits
33	Synonyms
1	Temperature Optimum [°C]
6	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.4.22.41 - cathepsin F

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

Hemoglobin + H2O

?

Opisthorchis viverrini

-

cathepsin F and cathepsin B can work in concert to hydrolyse hemoglobin at low pH

708053

-

-

?

Ii-MHC class II complex + H2O

?

Mus musculus

-

-

137264

-

-

?

LAMP 2 protein + H2O

?

Homo sapiens

-

-

731340

-

-

?

additional information

?

-

7 entries

additional information

?

-

Homo sapiens

-

the enzyme likely plays a regulatory role in the processing in the invariant chain that is assoviated with the major histocompatibility complex class II

652895

-

652895

?

additional information

?

-

Homo sapiens

-

the enzyme is a cysteine protease

669249

-

-

?

additional information

?

-

Homo sapiens

-

the enzyme plays a role in tumor-induced angiogenesis, cell migration, proliferation, apoptosis, and connective tissue degradation

668085

-

-

?

additional information

?

-

Homo sapiens

-

involved in atherosclerotic inflammatory processes

683112

-

-

?

additional information

?

-

Opisthorchis viverrini

-

cathepsin F degrades extracellular matrix proteins more effectively than capthespin B1 at physiological pH

708053

-

-

?

additional information

?

-

Teladorsagia circumcincta

Q218Y2

cathepsin F-1 is developmentally regulated

669001

-

-

?

additional information

?

-

Teladorsagia circumcincta

-

cathepsin F-1 is developmentally regulated

669001

-

-

?