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Information on EC 3.4.22.41 - cathepsin F

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.41 cathepsin F
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
cf-11, ov-cf-1, cat f, tci-cf-1, cathepsin f-1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
The recombinant enzyme cleaves synthetic substrates with Phe and Leu (better than Val) in P2, with high specificity constant (kcat/Km) comparable to that of cathepsin L
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Cathepsin F is a lysosomal cysteine endopeptidase of family C1, papain family, most activite at pH 5.9. The enzyme is unstable at neutral pH values and is inhibited by compound E-64. Cathepsin F is expressed in most tissues of human, mouse and rat. Human gene locus: 11q13.1-13.3; endopeptidase
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