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Literature summary for 3.4.22.41 extracted from

  • Oeoerni, K.; Sneck, M.; Broemme, D.; Pentikaeinen, M.O.; Lindstedt, K.A.; Maeyraenpaeae, M.; Aitio, H.; Kovanen, P.T.
    Cysteine protease cathepsin F is expressed in human atherosclerotic lesions, is secreted by cultured macrophages, and modifies low density lipoprotein particles in vitro (2004), J. Biol. Chem., 279, 34776-34784.
    View publication on PubMed
Search for more literature for 3.4.22.41

Activating Compound

Activating Compound Comment Organism Structure
chondroitin-4-sulfate activates apoB-100/LDL degradation by cathepsin F Homo sapiens
chondroitin-6-sulfate activates apoB-100/LDL degradation by cathepsin F Homo sapiens
dermatan sulfate activates apoB-100/LDL degradation by cathepsin F Homo sapiens
heparan sulfate activates apoB-100/LDL degradation by cathepsin F Homo sapiens
human aortic proteoglycans activates apoB-100/LDL degradation by cathepsin F Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of mature enzyme in Escherichia coli Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular secretion of the enzyme by macrophage cell culture Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is a cysteine protease ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage monocyte-derived cell culture, enzyme is secreted Homo sapiens
-
additional information expression mainly in coronary atherosclerotic plaques Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
apoB-100 + H2O apoB-100 is part of LDL particles Homo sapiens ?
-
 ?
additional information the enzyme is a cysteine protease Homo sapiens ?
-
 ?
additional information the enzyme is a cysteine protease and modifies low density lipoprotein particles in vitro Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
CatF
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
 about Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
additional information
-
 slightly acidic pH optimum, rapid inactivation at neutral pH Homo sapiens