3.4.22.41: cathepsin F

This is an abbreviated version!
For detailed information about cathepsin F, go to the full flat file.

Reaction

The recombinant enzyme cleaves synthetic substrates with Phe and Leu (better than Val) in P2, with high specificity constant (kcat/Km) comparable to that of cathepsin L =

Synonyms

cat F, CatF, cathepsin f, cathepsin F-1, CATSF, CF-1, CF-11, CF-4, CF-6, cf1, CtF, CTSF, Ov-CF-1, PwCP1, PwCP10, PwCP11, PwCP2, PwCP3, PwCP4, PwCP5, PwCP6, PwCP7, PwCP8, PwCP9, Tci-CF-1

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.41 cathepsin F

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Results	in table
9	Activating Compound
53	AA Sequence
6	Application
1	CAS Registry Number
20	Cloned(Commentary)
2	Crystallization (Commentary)
46	Disease/ Diagnostics
4	Expression
3	General Information
28	Inhibitors
4	kcat/KM [mM/s]
6	KM Value [mM]
16	Localization
3	Metals/Ions
17	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
40	Organism
2	PDB ID
7	pH Optimum
5	pH Range
7	pH Stability
2	pI Value
7	Posttranslational Modification
2	Protein Variants
6	Purification (Commentary)
2	Reaction
2	Reaction Type
30	Reference
1	Renatured (Commentary)
87	Source Tissue
4	Specific Activity [micromol/min/mg]
2	Storage Stability
47	Substrates and Products (Substrate)
5	Subunits
33	Synonyms
1	Temperature Optimum [°C]
6	Turnover Number [1/s]

Engineering

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Engineering on EC 3.4.22.41 - cathepsin F

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

N97Q/N108Q/N170Q

Homo sapiens

-

KM-value for benzyloxycarbonyl-Phe-Arg-4-methylcoumaryl-7-amide is 2fold higher than that of the wild-type enzyme, the turnover number is 2fold lower

649185

additional information

Mus musculus

-

generation of cat F-deficient mice by homologous recombination, the mutation leads to weight loss and death within 6 months, deficient neurons accumulate eosiniophilic granules causing neuronal ceroid lipofuscinosis beginning as early as 6 weeks of age, overview

670246